ZN418_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZN418_HUMAN
• UniProt AC: Q8TF45
• Protein Name: Zinc finger protein 418
• Gene Name: ZNF418
• Organism: Homo sapiens (Human).
• Sequence Length: 676
• Subcellular Localization: Nucleus .
• Protein Description: Transcriptional repressor..
• Protein Sequence: MQGTVAFEDVAVNFSQEEWSLLSEVQRCLYHDVMLENWVLISSLGCWCGSEDEEAPSKKSISIQRVSQVSTPGAGVSPKKAHSCEMCGAILGDILHLADHQGTHHKQKLHRCEAWGNKLYDSSNRPHQNQYLGEKPYRSSVEEALFVKRCKFHVSEESSIFIQSGKDFLPSSGLLLQEATHTGEKSNSKPECESPFQWGDTHYSCGECMKHSSTKHVFVQQQRLPSREECYCWECGKSFSKYDSVSNHQRVHTGKRPYECGECGKSFSHKGSLVQHQRVHTGKRPYECGECGKSFSHKGSLVQHQRVHTGERPYECGECGKSFSQNGTLIKHQRVHTGERPYECEECGKCFTQKGNLIQHQRGHTSERPYECEECGKCFSQKGTLTEHHRVHTRERPYECGECGKSFSRKGHLRNHQRGHTGERPYECGECGKSFSRKGNLIQHQRSHTGERPYECRECRKLFRGKSHLIEHQRVHTGERPYECNECGKSFQDSSGFRVHQRVHTGEKPFECSECGKSFPQSCSLLRHRRVHTGERPYECGECGKSFHQSSSLLRHQKTHTAERPYECRECGKFFSSLLEHRRVHTGERPYECRECGKTFTRRSAHFKHQRLHTRGKPYECSECGKSFAETFSLTEHRRVHTGERPYECSECGKSFHRSSSLLRHQRVHTERSPYK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
77	Phosphorylation	STPGAGVSPKKAHSC CCCCCCCCHHHCCCC	30.04	24719451
98	Phosphorylation	LGDILHLADHQGTHH HHHHHHHHCCCCCCH	11.07	-
106	Ubiquitination	DHQGTHHKQKLHRCE CCCCCCHHHHHHHHH	41.33	-
127	Ubiquitination	YDSSNRPHQNQYLGE CCCCCCCCCCCCCCC	35.67	21906983
214	Phosphorylation	ECMKHSSTKHVFVQQ HHHHCCCCCEEEEEC	28.34	-
235	Phosphorylation	EECYCWECGKSFSKY CCEEECCCCCCCCCC	3.44	-
238	Phosphorylation	YCWECGKSFSKYDSV EECCCCCCCCCCCCC	21.75	24719451
309	Phosphorylation	VQHQRVHTGERPYEC EEEEECCCCCCCCCC	37.57	28674419
314	Phosphorylation	VHTGERPYECGECGK CCCCCCCCCCCCCCC	30.03	-
337	Phosphorylation	IKHQRVHTGERPYEC EEEEECCCCCCCEEC	37.57	-
406	Phosphorylation	ECGECGKSFSRKGHL ECCCCCCCCCCCCCC	17.46	17081983
408	Phosphorylation	GECGKSFSRKGHLRN CCCCCCCCCCCCCCC	39.93	17081983
434	Phosphorylation	ECGECGKSFSRKGNL CCCCCCCCCCCCCCC	17.46	17081983
436	Phosphorylation	GECGKSFSRKGNLIQ CCCCCCCCCCCCCCC	39.93	17081983
477	Phosphorylation	IEHQRVHTGERPYEC EECCCCCCCCCCEEC	37.57	-
505	Phosphorylation	RVHQRVHTGEKPFEC EEEEEEECCCCCEEC	44.15	-
533	Phosphorylation	LRHRRVHTGERPYEC HHCCCCCCCCCCCCC	37.57	28674419
538	Phosphorylation	VHTGERPYECGECGK CCCCCCCCCCCCCCC	30.03	-
551	Phosphorylation	GKSFHQSSSLLRHQK CCCHHHHHHHHHCCC	20.59	24719451
552	Phosphorylation	KSFHQSSSLLRHQKT CCHHHHHHHHHCCCC	36.35	24719451
586	Phosphorylation	LEHRRVHTGERPYEC HHCCCCCCCCCCCCH	37.57	29214152
642	Phosphorylation	TEHRRVHTGERPYEC CCCCCCCCCCCCEEC	37.57	27251275
647	Phosphorylation	VHTGERPYECSECGK CCCCCCCEECCCCCC	35.47	-
650	Phosphorylation	GERPYECSECGKSFH CCCCEECCCCCCCCH	24.79	27251275
660	Phosphorylation	GKSFHRSSSLLRHQR CCCCHHHHHHHHHHH	25.59	24719451
661	Phosphorylation	KSFHRSSSLLRHQRV CCCHHHHHHHHHHHH	32.44	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZN418_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZN418_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZN418_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KR107_HUMAN	KRTAP10-7	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.