ZN365_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZN365_HUMAN
• UniProt AC: Q70YC5
• Protein Name: Protein ZNF365
• Gene Name: ZNF365
• Organism: Homo sapiens (Human).
• Sequence Length: 407
• Subcellular Localization: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . localizes to the centrosome at all stages of the cell cycle.
• Protein Description: Involved in the regulation of neurogenesis. Negatively regulates neurite outgrowth. [PubMed: 17389905 Involved in the morphogenesis of basket cells in the somatosensory cortex during embryogenesis. Involved in the positive regulation of oligodendrocyte differentiation during postnatal growth. Involved in dendritic arborization, morphogenesis of spine density dendrite, and establishment of postsynaptic dendrite density in cortical pyramidal neurons (By similarity Involved in homologous recombination (HR) repair pathway. Required for proper resolution of DNA double-strand breaks (DSBs) by HR. Is required for recovery of stalled replication forks, and directly contributes to genomic stability. Interacts with PARP1 and mediates MRE11-dependent DNA end resection during replication fork recovery]
• Protein Sequence: MQQKAFEESRYPWQESFENVAVCLPLRCPRCGDHTRFRSLSSLRAHLEFSHSYEERTLLTKCSLFPSLKDTDLVTSSELLKPGKLQSSGNVVKQKPSYVNLYSISHEHSKDRKPFEVVAERPVSYVQTYTAMDLHADSLDGTRSGPGLPTSDTKASFEAHVREKFNRMVEAVDRTIEKRIDKLTKELAQKTAELLEVRAAFVQLTQKKQEVQRRERALNRQVDVAVEMIAVLRQRLTESEEELLRKEEEVVTFNHFLEAAAEKEVQGKARLQDFIENLLQRVELAEKQLEYYQSQQASGFVRDLSGHVLTDISSNRKPKCLSRGHPHSVCNHPDLKAHFHPKGRNHLKKAKDDRASMQPAKAIHEQAESSRDLCRPPKKGELLGFGRKGNIRPKMAKKKPTAIVNII

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Ubiquitination	----MQQKAFEESRY ----CCCHHHHHHCC	37.84	30230243
9	Phosphorylation	QQKAFEESRYPWQES CCHHHHHHCCCCHHH	29.89	24719451
16	Phosphorylation	SRYPWQESFENVAVC HCCCCHHHHCCEEEE	23.82	24719451
39	Phosphorylation	GDHTRFRSLSSLRAH CCCHHCCCHHHHHHH	29.86	22167270
41	Phosphorylation	HTRFRSLSSLRAHLE CHHCCCHHHHHHHHH	28.68	22167270
42	Phosphorylation	TRFRSLSSLRAHLEF HHCCCHHHHHHHHHH	27.45	22167270
61	Ubiquitination	EERTLLTKCSLFPSL HHHHHHHHHCCCCCC	23.07	30230243
69	Ubiquitination	CSLFPSLKDTDLVTS HCCCCCCCCCCCCCH	64.02	30230243
81	Acetylation	VTSSELLKPGKLQSS CCHHHHCCCCCCCCC	65.43	11688369
84	Ubiquitination	SELLKPGKLQSSGNV HHHCCCCCCCCCCCE	52.45	30230243
97	Phosphorylation	NVVKQKPSYVNLYSI CEEECCCCEEEEEEC	49.07	24850871
138	Phosphorylation	AMDLHADSLDGTRSG EEECCCCCCCCCCCC	29.19	-
154	Ubiquitination	GLPTSDTKASFEAHV CCCCCCCHHHHHHHH	47.20	30230243
175	Phosphorylation	MVEAVDRTIEKRIDK HHHHHHHHHHHHHHH	29.08	-
239	Phosphorylation	LRQRLTESEEELLRK HHHHCCCCHHHHHHH	45.10	22210691
287	Ubiquitination	QRVELAEKQLEYYQS HHHHHHHHHHHHHHH	55.35	30230243
291	Phosphorylation	LAEKQLEYYQSQQAS HHHHHHHHHHHHHHH	18.52	-
305	Phosphorylation	SGFVRDLSGHVLTDI HCCCCCCCCCCEEEC	31.01	24076635
310	Phosphorylation	DLSGHVLTDISSNRK CCCCCCEEECCCCCC	30.14	24719451
369	Phosphorylation	AIHEQAESSRDLCRP HHHHHHHHCCHHCCC	33.42	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZN365_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZN365_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZN365_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.