ZHX2_MOUSE - dbPTM
ZHX2_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ZHX2_MOUSE
UniProt AC Q8C0C0
Protein Name Zinc fingers and homeoboxes protein 2
Gene Name Zhx2
Organism Mus musculus (Mouse).
Sequence Length 836
Subcellular Localization Nucleus .
Protein Description Acts as a transcriptional repressor. Represses the promoter activity of the CDC25C gene stimulated by NFYA (By similarity)..
Protein Sequence MASKRKSTTPCMVRTSQVLEQDMLEEADRAKDKGAGMPQSDVTKDSWAAEPEHSSKETEVVEVKSMGENLSKKLQGGYECKYCPYSTQNLNEFTEHVDMQHPNVILNPLYVCAECNFTTKKYDSLSDHNSKFHPGETNFKLKLIKRNNQTVLEQSIEATNHVVPITASGPGSSDNDPGVSVGKTPMTKTGKLKADAKKVPKKPDEAAPENHMEGTARLVTDTAEILARLGSVELLQDSLGHVMPSVQLPPNINLVPKVPVPLNTTKYNSALDTNATMINSFNKFPYPTQAELSWLTAASKHPEEHIRIWFATQRLKHGISWSPEEVEEARKKMFNGTIQSVPPTITVLPAQLTPTKVSQPILQTALPCQILGQPSLVLTQVTSGSTTVSCSPITLAVAGVTNHGQKRPLVTPQAAPEPKRPHIAQVPEPPPKVANTPLTPASDRKKTKLQIAHLKASFLQSQFPDDAEVYRLIEVTGLARSEIKKWFSDHRYRCQRGIVHITSESLAKDQMAITGTRHGRTYHVYPDFAPQKFKEKSQGQLKTLEDSFLKSSFPTQAEVERLRVETKLSRREIDSWFSERRKLRDSMEQAVLDSMGSGKKGSDAVAPNGALSRLDQLSGAQLAGSLPSPSSAIVQNQEQVHLLRSTFARTQWPTPQEYDQLAAKTGLVRTEIVRWFKENRCLLKTGTLSWLEQYQRHHMSDDRGRDAVSRKVAKQVAESPKNGSEAAHQYAKDPKALSEEDSEKLVPRMKVGGDPTKDCLAGKPSEATSDRSEGSRDGQGSEENEESGIVDFVEVTVGEEDAISEKWGSWSRRVAEGTVERADSDSDSTPAEAGQA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
16PhosphorylationTPCMVRTSQVLEQDM
CCCCCCHHHHHHHHH		14.0214729942
173PhosphorylationTASGPGSSDNDPGVS
EECCCCCCCCCCCCC		46.4728285833
238PhosphorylationSVELLQDSLGHVMPS
CHHHHHHCCCCCCCC		24.2428059163
245PhosphorylationSLGHVMPSVQLPPNI
CCCCCCCCCCCCCCC		12.3728059163
344PhosphorylationTIQSVPPTITVLPAQ
CCCCCCCEEEEEECC		24.1826745281
346PhosphorylationQSVPPTITVLPAQLT
CCCCCEEEEEECCCC		20.6126643407
353PhosphorylationTVLPAQLTPTKVSQP
EEEECCCCCCCCCCC		19.4826643407
355PhosphorylationLPAQLTPTKVSQPIL
EECCCCCCCCCCCHH		38.5526643407
439PhosphorylationKVANTPLTPASDRKK
CCCCCCCCCHHHHCC		20.29-
505PhosphorylationIVHITSESLAKDQMA
EEEECCHHHHCCCEE		33.1328059163
514PhosphorylationAKDQMAITGTRHGRT
HCCCEEECCCCCCCE		23.9828059163
542UbiquitinationEKSQGQLKTLEDSFL
HHCCCCCCHHHHHHH		43.08-
599UbiquitinationLDSMGSGKKGSDAVA
HHHCCCCCCCCCCCC		56.51-
618PhosphorylationLSRLDQLSGAQLAGS
HHHHHHCCCCHHCCC		26.8426643407
625PhosphorylationSGAQLAGSLPSPSSA
CCCHHCCCCCCCCHH		31.3426643407
628PhosphorylationQLAGSLPSPSSAIVQ
HHCCCCCCCCHHHCC		42.5826745281
630PhosphorylationAGSLPSPSSAIVQNQ
CCCCCCCCHHHCCCH		36.4226643407
631PhosphorylationGSLPSPSSAIVQNQE
CCCCCCCHHHCCCHH		25.9626643407
664UbiquitinationEYDQLAAKTGLVRTE
HHHHHHHHHCCCHHH		37.2027667366
719PhosphorylationVAKQVAESPKNGSEA
HHHHHHHCCCCHHHH		31.2829899451
724PhosphorylationAESPKNGSEAAHQYA
HHCCCCHHHHHHHHH		33.1923984901
732AcetylationEAAHQYAKDPKALSE
HHHHHHHCCHHHCCH		70.416571409
738PhosphorylationAKDPKALSEEDSEKL
HCCHHHCCHHHHHHH		43.7428833060
742PhosphorylationKALSEEDSEKLVPRM
HHCCHHHHHHHHCCC		39.6528833060
809PhosphorylationAISEKWGSWSRRVAE
HHHHHHCCHHHHHHC		22.2923375375
818PhosphorylationSRRVAEGTVERADSD
HHHHHCCCCEECCCC		15.6528833060
824PhosphorylationGTVERADSDSDSTPA
CCCEECCCCCCCCCC		37.7225521595
826PhosphorylationVERADSDSDSTPAEA
CEECCCCCCCCCCCC		37.1027087446
828PhosphorylationRADSDSDSTPAEAGQ
ECCCCCCCCCCCCCC		40.0027087446
829PhosphorylationADSDSDSTPAEAGQA
CCCCCCCCCCCCCCC		31.3528833060
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ZHX2_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ZHX2_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ZHX2_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
RASH_MOUSEHrasphysical
16644864
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ZHX2_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Identification of phosphoproteins and their phosphorylation sites inthe WEHI-231 B lymphoma cell line.";
Shu H., Chen S., Bi Q., Mumby M., Brekken D.L.;
Mol. Cell. Proteomics 3:279-286(2004).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-16, AND MASSSPECTROMETRY.

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