ZFAN5_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZFAN5_MOUSE
• UniProt AC: O88878
• Protein Name: AN1-type zinc finger protein 5
• Gene Name: Zfand5
• Organism: Mus musculus (Mouse).
• Sequence Length: 213
• Subcellular Localization: Cytoplasm.
• Protein Description: Involved in protein degradation via the ubiquitin-proteasome system. May act by anchoring ubiquitinated proteins to the proteasome. Plays a role in ubiquitin-mediated protein degradation during muscle atrophy. Plays a role in the regulation of NF-kappa-B activation and apoptosis. Inhibits NF-kappa-B activation triggered by overexpression of RIPK1 and TRAF6 but not of RELA. Inhibits also tumor necrosis factor (TNF), IL-1 and TLR4-induced NF-kappa-B activation in a dose-dependent manner. Overexpression sensitizes cells to TNF-induced apoptosis. Is a potent inhibitory factor for osteoclast differentiation..
• Protein Sequence: MAQETNQTPGPMLCSTGCGFYGNPRTNGMCSVCYKEHLQRQQNSGRMSPMGTASGSNSPTSDSASVQRADAGLNNCEGAAGSTSEKSRNVPVAALPVTQQMTEMSISREDKITTPKTEVSEPVVTQPSPSVSQPSSSQSEEKAPELPKPKKNRCFMCRKKVGLTGFDCRCGNLFCGLHRYSDKHNCPYDYKAEAAAKIRKENPVVVAEKIQRI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
44	Phosphorylation	HLQRQQNSGRMSPMG HHHHHHHCCCCCCCC	24.36	25619855
48	Phosphorylation	QQNSGRMSPMGTASG HHHCCCCCCCCCCCC	15.46	25521595
52	Phosphorylation	GRMSPMGTASGSNSP CCCCCCCCCCCCCCC	16.05	27087446
54	Phosphorylation	MSPMGTASGSNSPTS CCCCCCCCCCCCCCC	42.46	23684622
56	Phosphorylation	PMGTASGSNSPTSDS CCCCCCCCCCCCCCC	31.47	27087446
58	Phosphorylation	GTASGSNSPTSDSAS CCCCCCCCCCCCCHH	31.11	25521595
60	Phosphorylation	ASGSNSPTSDSASVQ CCCCCCCCCCCHHHH	45.01	25619855
61	Phosphorylation	SGSNSPTSDSASVQR CCCCCCCCCCHHHHH	32.71	25619855
63	Phosphorylation	SNSPTSDSASVQRAD CCCCCCCCHHHHHHH	23.39	25619855
65	Phosphorylation	SPTSDSASVQRADAG CCCCCCHHHHHHHHC	23.80	25619855
82	Phosphorylation	NCEGAAGSTSEKSRN CCCCCCCCCCHHHCC	24.84	22802335
86	Ubiquitination	AAGSTSEKSRNVPVA CCCCCCHHHCCCCEE	55.25	22790023
102	Phosphorylation	LPVTQQMTEMSISRE EECCHHHHHCCCCCC	24.97	21454597
105	Phosphorylation	TQQMTEMSISREDKI CHHHHHCCCCCCCCC	15.92	21454597
107	Phosphorylation	QMTEMSISREDKITT HHHHCCCCCCCCCCC	23.47	21454597
113	Phosphorylation	ISREDKITTPKTEVS CCCCCCCCCCCCCCC	42.67	26643407
114	Phosphorylation	SREDKITTPKTEVSE CCCCCCCCCCCCCCC	26.68	26643407
117	Phosphorylation	DKITTPKTEVSEPVV CCCCCCCCCCCCCEE	42.71	26643407
120	Phosphorylation	TTPKTEVSEPVVTQP CCCCCCCCCCEECCC	29.92	26643407
128	Phosphorylation	EPVVTQPSPSVSQPS CCEECCCCCCCCCCC	21.71	25338131
188	Phosphorylation	SDKHNCPYDYKAEAA CCCCCCCCCHHHHHH	33.82	29514104
209	Acetylation	NPVVVAEKIQRI--- CCEEEEEECCCC---	34.11	23806337

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZFAN5_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZFAN5_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZFAN5_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TNFA_MOUSE	Tnf	physical	22665488

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.