ZDP_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZDP_ARATH
• UniProt AC: Q84JE8
• Protein Name: Polynucleotide 3'-phosphatase ZDP
• Gene Name: ZDP
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 694
• Subcellular Localization: Nucleus, nucleoplasm . Not found in the nucleolus (PubMed:22325353). Co-localizes in nucleoplasmic foci with APE1L and ROS1, two components of the DNA demethylase machinery (PubMed:25569774).
• Protein Description: Nick-sensing 3'-phosphoesterase involved in a base excision repair pathway required for active DNA demethylation. The N-terminal DNA-binding domain binds specifically to gap sites and sharply bends the target DNA. Lacks 5'-kinase activity but is capable of 3'-phosphoglycolate end processing. Inactive on 3'-alpha,beta-unsaturated aldehyde (3'-dRP). Protects partially genes from transcriptional silencing by preventing promoter DNA hypermethylation..
• Protein Sequence: MITVAPFVSLRFQFPLYIINRSTLFFRERTQYLVYNTCHILRTTAKTMPVVAEYAKSNRSSCRSCSNKIAVKSLRLGLISKGRGGVDMTRWHHFDCFPTDSESIASVDDIQGLSALEKEDQDALTKLVEQCGKVPAKKPDEKKGKAKKHIMGPKGLTKAATSSKVIADNAKSSRSSCNRCSQTIVSKDLRVGLVTEDSRGFDITRWHHLGCFPIDFHPIDSVEDIGGYSSLEKGDQMELKYLAEVNKKDKTLIDDVQKMDEGDDEAIADNELTEETKKGKHSPVAKLVEQPGEPAKEDEDEESKKPASDEISEQKTKDVKNSPDSSKVISEYAKSSRSTCKKCSQTIAAKELRLGLVTRNFRGFDMKQWHHLGCFPVDSDPIVSVEDIGGFSELQSGDQDALKELVQQCGKQTLVDKMDEDNDDTEAKIKLTEETNKRKHSEVGEMVEEDESLTKAKQQMAKTHKVNMSESTSQVEVEAEITLSASDVKDKYRDANLLPKWKAFETVIFLERDDGLNDSEKIAAFDFDGCLAKTSVKIVGADAWSLMYPSIPEKLQSLHDQGYKLVIFTNESNIDRWKNKRQAAVDSKIGRLNSFIERVKVPIQVFIACGVSSSGGKGGKDDLYRKPKAGMWQLMKKHFNSGIAIDMDKSFYVGDAAGRKMDHSDADIKFAQASGLKFFTPEEYFIPSSTSPGT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
162	Phosphorylation	GLTKAATSSKVIADN HHCHHHCCCCHHHCC		24894044
195	Phosphorylation	DLRVGLVTEDSRGFD CCEEEEEECCCCCCC		30407730
198	Phosphorylation	VGLVTEDSRGFDITR EEEEECCCCCCCCCE		30291188
204	Phosphorylation	DSRGFDITRWHHLGC CCCCCCCCEEEEECE		30407730
282	Phosphorylation	ETKKGKHSPVAKLVE HHHCCCCCCHHHHCC		25561503
308	Phosphorylation	EESKKPASDEISEQK HHHCCCCCHHHHHHH		25561503
322	Phosphorylation	KTKDVKNSPDSSKVI HHHHCCCCCCHHHHH		19376835
325	Phosphorylation	DVKNSPDSSKVISEY HCCCCCCHHHHHHHH		19880383
326	Phosphorylation	VKNSPDSSKVISEYA CCCCCCHHHHHHHHH		19880383
330	Phosphorylation	PDSSKVISEYAKSSR CCHHHHHHHHHHHCH		19880383
332	Phosphorylation	SSKVISEYAKSSRST HHHHHHHHHHHCHHH		19880383
413	Phosphorylation	VQQCGKQTLVDKMDE HHHHCHHHHHHCCCC		22074104
688	Phosphorylation	PEEYFIPSSTSPGT- CHHHCCCCCCCCCC-		23776212
689	Phosphorylation	EEYFIPSSTSPGT-- HHHCCCCCCCCCC--		23776212
690	Phosphorylation	EYFIPSSTSPGT--- HHCCCCCCCCCC---		23776212
691	Phosphorylation	YFIPSSTSPGT---- HCCCCCCCCCC----		23776212
694	Phosphorylation	PSSTSPGT------- CCCCCCCC-------		23776212

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZDP_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZDP_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZDP_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
XRCC1_ARATH	ATXRCC1	physical	23316050

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.