dbPTM

XRCC1_ARATH - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	XRCC1_ARATH
UniProt AC	Q24JK4
Protein Name	DNA-repair protein XRCC1 {ECO:0000303\|PubMed:11909950}
Gene Name	XRCC1 {ECO:0000303\|PubMed:11909950}
Organism	Arabidopsis thaliana (Mouse-ear cress).
Sequence Length	353
Subcellular Localization	Nucleus . Accumulates at sites of DNA damage.
Protein Description	Corrects defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents (By similarity). Involved in DNA demethylation pathway by stimulating cytosine methylation (5-meC) excision, gap tailoring, and DNA ligation..
Protein Sequence	MSQKRNLPSWMSSRDPEITPSKSHCKKPKDEGPTEEHNSRNAPSNKSEHAEPSSNTTEFSKLMEGVVFVLSGFVNPERSTLRSQALTMGATYQPDWNAGSTLLICAFPNTPKFRQVETNGGTIISKEWITECYAQKKLVDIEQYLMHAGKPWRKSSSPQDANREKREHLSKKPEKQVEKKTETRGTPSTSSKNRSACNLVKEPFFVTEVKKWARDDLSQTISWLESQEEKPEPGEIKRIAAEGVLTCLQDAIDSLEQKQDIGSVTELWSFVPRVVKELGKMESSSKKENSTASKEEVCKQAKSWKKIYEAELAKPGEDESTSRVACGYDSDMTVEMTEEEIELAYRNVSLECL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	Reference
283	Phosphorylation	KELGKMESSSKKENS HHHHHCCCCCCCCCC	19880383
284	Phosphorylation	ELGKMESSSKKENST HHHHCCCCCCCCCCC	19880383
303	Phosphorylation	EVCKQAKSWKKIYEA HHHHHHHHHHHHHHH	24894044

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of XRCC1_ARATH !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of XRCC1_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of XRCC1_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of XRCC1_ARATH !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of XRCC1_ARATH

Related Literatures of Post-Translational Modification