YI14_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: YI14_SCHPO
• UniProt AC: Q9P7B3
• Protein Name: Putative cation exchanger C521.04c
• Gene Name: SPAC521.04c
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 881
• Subcellular Localization: Endoplasmic reticulum membrane ; Multi-pass membrane protein .
• Protein Description: Putative cation exchanger..
• Protein Sequence: MSQPADINQSESSAETITQGRRADRPEETPSSSVYEQNLRFGDFLMPTVGDADATDSLSQSTNDRDIYSPREIDQYTRKVSSRTDPSTSTISNARQHPRNSVSRLSRSSSNVRQQRDIPKQNFKVRPLSPLRGQSPASLRSEESFTLKERQNAINKTRAFGMRLWKPALYKKFRSINRDADIDIHDEPLKRPNTSISNVIWLICFGAPLFLVIFICYIFFTVLSFFNVPDAIVYSKLCRGLMFYLLYPFGQHVRHKVKRLSVRSPAHPIYQTQHSHYDETPTSHHPDPARLNFLSFSFCVNPMNQSLDCNTTPHRRNASSIIYTLMYYLIIAPTLLITSAICMFTIFFVPCARTLWAICRHLRTCPLSLSFRPNLALPLSMDSSDVVLLCVKKAASWKYYKYTIDGIYIIYFDMLALIIPTIFFGFFGSQGHWFTSSVFLFTASLVSIIPLAYFIGMAVASISAQSSMGMGAFINAFFGSVIEVFLYSVALRKGNAGLVEGSVIGSILAGLLLMPGLSMCAGAIRKKFQFFNIKSAGATSTMLLFAVLGAFAPTMLFRIYGPFRLDCEPCGANCQKCTKHYVLENDSLYKNRVLPFTYCCSIMLVLAYAIGLWFTLRTHASHIWQNFTADDISFLKAEEEVGEPVNQDTAGNMSDSSEGGEAVVNGNSQHHHNRDDASSGLSSNGSENESLEHEPTNELPQRPLVNQSQNSHGDDAPNWSRSKSAIILLSATFLYSLIAEILVEHVDTVLDKFAISEKFLGLTLFALVPNTTEFMNAISFALNENIALSMEIGSAYALQVCLLQIPCLMGYSLFQYYRSGDSISFKHLFTMVFPTWDMICVMICVFLLTYVHSEGKSNYFKGSILVLAYLVSMLGFTFFNY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
29	Phosphorylation	RADRPEETPSSSVYE CCCCCCCCCCCCHHH	27.15	29996109
31	Phosphorylation	DRPEETPSSSVYEQN CCCCCCCCCCHHHCC	42.54	25720772
32	Phosphorylation	RPEETPSSSVYEQNL CCCCCCCCCHHHCCC	25.65	25720772
33	Phosphorylation	PEETPSSSVYEQNLR CCCCCCCCHHHCCCC	32.81	29996109
35	Phosphorylation	ETPSSSVYEQNLRFG CCCCCCHHHCCCCCC	17.47	25720772
57	Phosphorylation	GDADATDSLSQSTND CCCCCCCCCCCCCCC	26.09	29996109
59	Phosphorylation	ADATDSLSQSTNDRD CCCCCCCCCCCCCCC	26.49	29996109
101	Phosphorylation	ARQHPRNSVSRLSRS HHHCCCCHHHHHHHC	23.81	25720772
103	Phosphorylation	QHPRNSVSRLSRSSS HCCCCHHHHHHHCCC	27.59	25720772
106	Phosphorylation	RNSVSRLSRSSSNVR CCHHHHHHHCCCCHH	29.07	29996109
108	Phosphorylation	SVSRLSRSSSNVRQQ HHHHHHHCCCCHHHH	34.44	25720772
109	Phosphorylation	VSRLSRSSSNVRQQR HHHHHHCCCCHHHHC	25.48	25720772
110	Phosphorylation	SRLSRSSSNVRQQRD HHHHHCCCCHHHHCC	40.36	25720772
129	Phosphorylation	NFKVRPLSPLRGQSP CCEEECCCCCCCCCC	25.27	28889911
135	Phosphorylation	LSPLRGQSPASLRSE CCCCCCCCCCHHCCC	25.84	28889911
138	Phosphorylation	LRGQSPASLRSEESF CCCCCCCHHCCCCCC	27.92	25720772
141	Phosphorylation	QSPASLRSEESFTLK CCCCHHCCCCCCCHH	51.51	24763107
144	Phosphorylation	ASLRSEESFTLKERQ CHHCCCCCCCHHHHH	21.34	24763107
146	Phosphorylation	LRSEESFTLKERQNA HCCCCCCCHHHHHHH	46.31	24763107

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of YI14_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of YI14_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of YI14_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ATG11_SCHPO	atg11	physical	26771498
SAD1_SCHPO	sad1	physical	26771498

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-129, AND MASSSPECTROMETRY.
PubMed: 18257517