dbPTM

Y34F_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	Y34F_DROME
UniProt AC	Q9W5D0
Protein Name	Uncharacterized protein CG43867
Gene Name	CG43867
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	1820
Subcellular Localization
Protein Description
Protein Sequence	MQWTAASCDQHDQHDPPAVNRNSIEQRTPANNCEVDPMDATGSTKHPHLPKQREADRPVSGSGGGSSSLTLSGAVTTSMEVTVSTTTTTTIIESSSSTNTTLEKNSPSPAGGSCSSGSGSLSPAYLQHHLQHHGSPLHHLQVHHHTAPPSPLAAVRSAQMGSSVANGAGPAAACLAVCCSPGSSHHHLGHVGHLATGHPLPHQLPHQLPHPSLYPLMAAAQLGYAGSSGPSSLVNSPALGRRKRYTSNSSNCSSQFNNNYAGLDVDSLDDMLRKLTELEQRVIEAEERAEEAEDKVRAMEQRLSEWPKPPPQQAQHPHSHSHPHQPIPSHPQEQQAKNHCSPSHQASGGATAGAAGSGLPPTQETEKTITSLEIQVEEQRQLRLHDARQIEAKAAKIKEWVNNKLRDLEEQNQLLREQNVKCNQQLELLKNHIANQSQRHSIVGPVRNSLSLDVQDFTGSGSNPEHRRRSESLDPQEIIGRPLTSSYPHHQHRRNLSMEPQELERNLVAAVDGLTLAPLSSISNKAPGGVPTESGVVTRPDSSDTDTAHDYAEIYTPSCEKLPAWMKNNPALMASGGNSSTTTTTTSELGVPRPPTPPLHRFPSWEAKIYQVANDGLAGAGTGTSTAESTASQEPDIQDGMGTNLSNGRRHGHGHGSGTGIGTGDGHGTLGSTPGTPLPPSRQQQTASGGFCDISVPVYATVKGRASQIRSMPFTGDSSDDSSDGEDHAVMLTHHSHNSSSTDNTETSTSGSASSPSKSLKTSSSLSPAKRSGSESPKNAKARVHIQSRTSTTPSSRINQHLQPSQHQHHTLSNQNHGHQLGAYTVTPSSGQLSLPRYHANALQPGSLPSPLQHMRGTVISDLSFESGLSDDYALPPDAVSESTCMDASMPSLLMRQSYVDSPSKKIESLEKMGHLAKLGGKLKTWRKRWFVLKNGSLNYWKSQHDVQRKPQGQIQLDEVCRINRAEGASTFEIDTGKKVYYLTADSHATMDDWIRVLQNVQRRNATKLLLSRDDQKPTVQGWVTKVKNGHPKKCWCVLLGKMFLYFKAPAETNPLGQINMRDARVEEVEHVSDSDSEEREDAAQDQARLTVAIYPAHQGPTYLILSGKPERDNWLYHLTVVSGGGPSAGTQYEQLVQKLMETDGDPNCVLWRHPILLHTKDTITAPLSSMHTETMQPEAIKLFKSIQLFMSVAVNQPGIDYHVVLAQNALQHALDMPELQTEMICILIKQTSRHLGQKLSVGVQVNKKLGKQTRQLLLCATQSLFTCDTQQAGHAQANGSSPTSIQAPSATPIIDCKSNPPVYSFVQGWQLLALAVSLFVPRSSRLLWYLKLHLSRNADTKTETGKYAAYCERALERTLKNGGRETKPSRMEVLSILLKNPYHHSLPHAIPVHMMNSTYQVVSFDGSTTIEEFQATLAHELGTRDATNGFCLFSDDPIEKDLEHYLEPLAKLCDVISKWETALREKGSGKFENSRVIQLSYKNRLYWKHTIKCETDKERLLLCYQTNSQIVQGRFPLSRELALELASLMSQIDMGDYSLEKSRDVGVGLKGLDKFYPYRYRDALGAEQLKDVQELLVSKWMLLKGRSTLDCVRIYLTCCRKWPYFGACLFQAKPRQSPESNTASGATPVAWLAVAEDALNVLELSTMAPVARYPYSSVMTFGGCQDDFMLVVSHDDGGGGEQKLLFAMSKPKILEITLLIADYMNALGHTVPGTPQMNSLTRNGSHRSLRTSQRPNLGGGSAVATGFSTNATTTAHNTLNSHATHTLNSNHSHTLSSSHHAGGGSQPGTLSSGHHQHHHIQQHHQPDILKSTPDHQRIK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
160 (in isoform 3)	Phosphorylation	-	5.86	21082442
160 (in isoform 5)	Phosphorylation	-	5.86	21082442
160 (in isoform 7)	Phosphorylation	-	5.86	21082442
283	Phosphorylation	TELEQRVIEAEERAE HHHHHHHHHHHHHHH	4.53	18327897
284	Phosphorylation	ELEQRVIEAEERAEE HHHHHHHHHHHHHHH	47.36	18327897
542	Phosphorylation	GVVTRPDSSDTDTAH CCEECCCCCCCCCCC	32.56	18327897
543	Phosphorylation	VVTRPDSSDTDTAHD CEECCCCCCCCCCCC	52.49	18327897
814	Phosphorylation	HQHHTLSNQNHGHQL CCCCCCCCCCCCCCE	50.19	18327897
816	Phosphorylation	HHTLSNQNHGHQLGA CCCCCCCCCCCCEEC	47.56	18327897
818	Phosphorylation	TLSNQNHGHQLGAYT CCCCCCCCCCEECEE	20.13	18327897
1073	Phosphorylation	VEEVEHVSDSDSEER EEEEEECCCCCHHHH	33.05	18327897
1075	Phosphorylation	EVEHVSDSDSEERED EEEECCCCCHHHHHH	35.21	18327897
1077	Phosphorylation	EHVSDSDSEEREDAA EECCCCCHHHHHHHH	45.36	18327897
1336	Phosphorylation	WYLKLHLSRNADTKT HHHHHHHHCCCCCCC	16.85	18327897

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of Y34F_DROME !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of Y34F_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of Y34F_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
DRK_DROME	drk	physical	14605208
MS87F_DROME	Mst87F	physical	14605208

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of Y34F_DROME

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome analysis of Drosophila melanogaster embryos."; Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.; J. Proteome Res. 7:1675-1682(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-542; SER-543; SER-1073;SER-1075 AND SER-1077, AND MASS SPECTROMETRY.	18327897 [Abstract]