VEGFC_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: VEGFC_HUMAN
• UniProt AC: P49767
• Protein Name: Vascular endothelial growth factor C
• Gene Name: VEGFC
• Organism: Homo sapiens (Human).
• Sequence Length: 419
• Subcellular Localization: Secreted.
• Protein Description: Growth factor active in angiogenesis, and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates KDR/VEGFR2 and FLT4/VEGFR3 receptors..
• Protein Sequence: MHLLGFFSVACSLLAAALLPGPREAPAAAAAFESGLDLSDAEPDAGEATAYASKDLEEQLRSVSSVDELMTVLYPEYWKMYKCQLRKGGWQHNREQANLNSRTEETIKFAAAHYNTEILKSIDNEWRKTQCMPREVCIDVGKEFGVATNTFFKPPCVSVYRCGGCCNSEGLQCMNTSTSYLSKTLFEITVPLSQGPKPVTISFANHTSCRCMSKLDVYRQVHSIIRRSLPATLPQCQAANKTCPTNYMWNNHICRCLAQEDFMFSSDAGDDSTDGFHDICGPNKELDEETCQCVCRAGLRPASCGPHKELDRNSCQCVCKNKLFPSQCGANREFDENTCQCVCKRTCPRNQPLNPGKCACECTESPQKCLLKGKKFHHQTCSCYRRPCTNRQKACEPGFSYSEEVCRCVPSYWKRPQMS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
101	Phosphorylation	REQANLNSRTEETIK HHHHCCCCCCHHHHH	43.69	18491316
106	Phosphorylation	LNSRTEETIKFAAAH CCCCCHHHHHHHHHH	24.20	18491316
175	N-linked_Glycosylation	SEGLQCMNTSTSYLS CCCCCCCCCCHHHHC	38.20	20145116
205	N-linked_Glycosylation	PVTISFANHTSCRCM CEEEEECCCCCCCHH	36.64	20145116
223	Phosphorylation	DVYRQVHSIIRRSLP HHHHHHHHHHHHHCC	22.36	24719451
240	N-linked_Glycosylation	LPQCQAANKTCPTNY CHHHHHCCCCCCCHH	43.09	UniProtKB CARBOHYD

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of VEGFC_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of VEGFC_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of VEGFC_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
VEGFC_HUMAN	VEGFC	physical	9233800

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 615907: Lymphedema, hereditary, 1D (LMPH1D)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

N-linked Glycosylation

"Structural determinants of growth factor binding and specificity byVEGF receptor 2.";
Leppanen V.M., Prota A.E., Jeltsch M., Anisimov A., Kalkkinen N.,Strandin T., Lankinen H., Goldman A., Ballmer-Hofer K., Alitalo K.;
Proc. Natl. Acad. Sci. U.S.A. 107:2425-2430(2010).
Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 112-215 IN COMPLEX WITH KDR,FUNCTION, DISULFIDE BONDS, GLYCOSYLATION AT ASN-175 AND ASN-205, ANDSUBUNIT.
PubMed: 20145116