VAV3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: VAV3_MOUSE
• UniProt AC: Q9R0C8
• Protein Name: Guanine nucleotide exchange factor VAV3
• Gene Name: Vav3
• Organism: Mus musculus (Mouse).
• Sequence Length: 847
• Protein Description: Exchange factor for GTP-binding proteins RhoA, RhoG and, to a lesser extent, Rac1. Binds physically to the nucleotide-free states of those GTPases (By similarity). Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. May be important for integrin-mediated signaling, at least in some cell types. In osteoclasts, along with SYK tyrosine kinase, required for signaling through integrin alpha-v/beta-1 (ITAGV-ITGB1), a crucial event for osteoclast proper cytoskeleton organization and function. This signaling pathway involves RAC1, but not RHO, activation. Necessary for proper wound healing. In the course of wound healing, required for the phagocytotic cup formation preceding macrophage phagocytosis of apoptotic neutrophils. Responsible for integrin beta-2-mediated macrophage adhesion and, to a lesser extent, contributes to beta-3-mediated adhesion. Does not affect integrin beta-1-mediated adhesion..
• Protein Sequence: MEPWKQCAQWLIHSKVLPPNHRVTWDSAQVFDLAQTLRDGVLLCQLLNNLRPHSINLKEINLRPQMSQFLCLKNIRTFLAACCDTFGMRKSELFEAFDLFDVRDFGKVIETLSRLSRTPIALATGIRPFPTEESINDEDIYKGLPDLIDETRVEDEEDLYDCVYGEDEGGEVYEDLMKAEEAQQPKSQENDIRSCCLAEIRQTEEKYTETLESIEKYFMAPLKRFLTAAEFDSVFINIPDLVKVHRSLMQEIHDSIVNKDDQNLYQVFINYKERLVIYGQYCSGVESAISNLDYISKTKEDVKLKLEECSKRANNGKFTLRDLLVVPMQRVLKYHLLLQELVKHTHDPMEKANLKLALDAMKDLAQYVNEVKRDNETLREIKQFQLSIENLNQPVLLFGRPQGDGEIRITTLDKHTKQERHIFLFDLAVIVCKRKGDNYEMKEIIDLQQYKIANNPTTDKENKKWSYGFYLIHTQGQNGLEFYCKTKDLKKKWLEQFEMALSNIRPDYADSNFHDFKMHTFTRVTSCRVCQMLLRGTFYQGYLCFKCGAKAHKECLGRVDNCGRVNSVEQGPFKPPEKRTNGLRRASRQVDPGLPKMQVIRNYTGTPAPGLHEGPPLHIQAGDTVELLRGDAHSVFWQGRNLASGEVGFFPSDAVKPSPCVPKPVDYSCQPWYAGPMERLQAETELINRVNSTYLVRHRTKESGEYAISIKYNNEAKHIKILTRDGFFHIAENRKFKSLMELVEYYKHHSLKEGFRTLDTTLQFPYKEPEQPAGQRGNRTGNSLLSPKVLGIAIARYDFCARDMRELSLLKGDMVKIYTKMSANGWWRGEVNGRVGWFPSTYVEEDE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
141	Phosphorylation	SINDEDIYKGLPDLI CCCHHHHHCCCHHHC	16.01	22817900
173	Phosphorylation	EDEGGEVYEDLMKAE CCCCCHHHHHHHHHH	10.22	22817900
187	Phosphorylation	EEAQQPKSQENDIRS HHHHCCCCCCCCHHH	49.78	30387612
317	Acetylation	SKRANNGKFTLRDLL HHHCCCCCCCHHHHH	36.98	7970555
692	Phosphorylation	ELINRVNSTYLVRHR HHHHHHCCEEEEEEE	18.64	29176673
693	Phosphorylation	LINRVNSTYLVRHRT HHHHHCCEEEEEEEE	18.70	29176673
717	Acetylation	IKYNNEAKHIKILTR EEECCCCCEEEEEEC	39.42	15608305
720	Acetylation	NNEAKHIKILTRDGF CCCCCEEEEEECCCC	31.23	15608315
738	Phosphorylation	AENRKFKSLMELVEY HHCCHHHHHHHHHHH	35.76	-
750	Phosphorylation	VEYYKHHSLKEGFRT HHHHHHCCHHHCCCC	40.64	-
783	Phosphorylation	RGNRTGNSLLSPKVL CCCCCCCCCCCHHHH	31.84	29176673
786	Phosphorylation	RTGNSLLSPKVLGIA CCCCCCCCHHHHEEE	28.15	24453211
797	Phosphorylation	LGIAIARYDFCARDM HEEEHHHCHHHHCCH	12.35	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of VAV3_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of VAV3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of VAV3_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TRAF6_MOUSE	Traf6	physical	27507811

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.