USH1G_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: USH1G_HUMAN
• UniProt AC: Q495M9
• Protein Name: Usher syndrome type-1G protein
• Gene Name: USH1G
• Organism: Homo sapiens (Human).
• Sequence Length: 461
• Subcellular Localization: Cytoplasm, cytosol. Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein. Detected at the tip of cochlear hair cell stereocilia. Recruited to the cell membrane via interaction with CDH23 or PCDH15 (By similarity)..
• Protein Description: Required for normal development and maintenance of cochlear hair cell bundles. Anchoring/scaffolding protein that is a part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing..
• Protein Sequence: MNDQYHRAARDGYLELLKEATRKELNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDIWGNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYLDSIAAKQSSLNPKLVGKLKDKAFREAERRIRECAKLQRRHHERMERRYRRELAERSDTLSFSSLTSSTLSRRLQHLALGSHLPYSQATLHGTARGKTKMQKKLERRKQGGEGTFKVSEDGRKSARSLSGLQLGSDVMFVRQGTYANPKEWGRAPLRDMFLSDEDSVSRATLAAEPAHSEVSTDSGHDSLFTRPGLGTMVFRRNYLSSGLHGLGREDGGLDGVGAPRGRLQSSPSLDDDSLGSANSLQDRSCGEELPWDELDLGLDEDLEPETSPLETFLASLHMEDFAALLRQEKIDLEALMLCSDLDLRSISVPLGPRKKILGAVRRRRQAMERPPALEDTEL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
53	Phosphorylation	ESLRLIVSRGGDPDK HHHEEEHHCCCCHHH	20.43	24719451
173	Phosphorylation	RRELAERSDTLSFSS HHHHHHCCCCCCHHH	26.84	23090842
175	Phosphorylation	ELAERSDTLSFSSLT HHHHCCCCCCHHHCC	26.08	23090842
177	Phosphorylation	AERSDTLSFSSLTSS HHCCCCCCHHHCCHH	25.77	23090842
179	Phosphorylation	RSDTLSFSSLTSSTL CCCCCCHHHCCHHHH	22.51	23090842
180	Phosphorylation	SDTLSFSSLTSSTLS CCCCCHHHCCHHHHH	33.39	23090842
182	Phosphorylation	TLSFSSLTSSTLSRR CCCHHHCCHHHHHHH	23.68	23090842
183	Phosphorylation	LSFSSLTSSTLSRRL CCHHHCCHHHHHHHH	26.98	23090842
184	Phosphorylation	SFSSLTSSTLSRRLQ CHHHCCHHHHHHHHH	28.29	23090842
185	Phosphorylation	FSSLTSSTLSRRLQH HHHCCHHHHHHHHHH	28.64	23090842
187	Phosphorylation	SLTSSTLSRRLQHLA HCCHHHHHHHHHHHH	18.55	23090842
197	Phosphorylation	LQHLALGSHLPYSQA HHHHHHCCCCCCCHH	23.77	22210691
209	Phosphorylation	SQATLHGTARGKTKM CHHHCCCCCCCHHHH	11.48	22210691
224	Acetylation	QKKLERRKQGGEGTF HHHHHHHHCCCCCCE	60.56	30593279
240	Phosphorylation	VSEDGRKSARSLSGL ECCCCHHCCHHHCCC	27.79	27174698
243	Phosphorylation	DGRKSARSLSGLQLG CCHHCCHHHCCCCCC	26.97	27174698
245	Phosphorylation	RKSARSLSGLQLGSD HHCCHHHCCCCCCCC	38.41	27174698
251	Phosphorylation	LSGLQLGSDVMFVRQ HCCCCCCCCEEEEEC	35.31	27174698
278	Phosphorylation	PLRDMFLSDEDSVSR CHHHHCCCCCCHHCH	27.91	23663014
282	Phosphorylation	MFLSDEDSVSRATLA HCCCCCCHHCHHHHH	21.68	23663014
284	Phosphorylation	LSDEDSVSRATLAAE CCCCCHHCHHHHHCC	21.83	23663014
356	Phosphorylation	SPSLDDDSLGSANSL CCCCCCCCCCCCCCC	41.44	-
362	Phosphorylation	DSLGSANSLQDRSCG CCCCCCCCCCCCCCC	27.42	-
438	Malonylation	VPLGPRKKILGAVRR CCCCCHHHHHHHHHH	44.43	26320211

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of USH1G_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of USH1G_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of USH1G_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
USH1C_HUMAN	USH1C	physical	28514442
MICA1_HUMAN	MICAL1	physical	28514442
POTEF_HUMAN	POTEF	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.