dbPTM

UPP_ARATH - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	UPP_ARATH
UniProt AC	Q9M336
Protein Name	Uracil phosphoribosyltransferase, chloroplastic
Gene Name	UPP
Organism	Arabidopsis thaliana (Mouse-ear cress).
Sequence Length	296
Subcellular Localization	Plastid, chloroplast .
Protein Description	Uracil phosphoribosyltransferase (UPRT) that catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate. Is probably the only functional UPRT, since the dual-domain proteins of the UKL family seem to lack this activity..
Protein Sequence	MACSIGNAFRCSSDTLRFAPRQQCSSRLNPNPSSFLSFNSSPILAQNLGASSSSLSRRTIRARTKMAASEASINGSNRMLVFVPPHPLIKHWISVLRNEQTPCPVFRNAIAELGRLLMYEASREWLPTVVGEIMSPMGPASVEFIDPREPIAVVPILRAGLALAEHASSVLPANKIYHLGVSRDEKTLLPSVYLNKLPDEFPKNSRVFLVDPVLATGGTIMAAMDLLKERGLSVQQIKVICAIAAPPALSKLNEKFPGLHVYAGIIDPEVNEKGYIIPGLGDAGDRSFGTETHWVK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2 (in isoform 2)	Acetylation	-	8.86	22223895
216	Phosphorylation	LVDPVLATGGTIMAA EECCCHHCCHHHHHH	31.80	24894044
219	Phosphorylation	PVLATGGTIMAAMDL CCHHCCHHHHHHHHH	14.66	24894044

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of UPP_ARATH !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of UPP_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of UPP_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
TL29_ARATH	APX4	physical	21798944
UCRIA_ARATH	PETC	physical	21798944

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of UPP_ARATH

Related Literatures of Post-Translational Modification