UBR2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: UBR2_MOUSE
• UniProt AC: Q6WKZ8
• Protein Name: E3 ubiquitin-protein ligase UBR2
• Gene Name: Ubr2
• Organism: Mus musculus (Mouse).
• Sequence Length: 1755
• Subcellular Localization: Nucleus . Associated with chromatin during meiosis.
• Protein Description: E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Plays a critical role in chromatin inactivation and chromosome-wide transcriptional silencing during meiosis via ubiquitination of histone H2A. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth (By similarity). Required for spermatogenesis, promotes, with Tex19.1, SPO11-dependent recombination foci to accumulate and drive robust homologous chromosome synapsis. [PubMed: 28708824 Polyubiquitinates LINE-1 retrotransposon encoded, LIRE1, which induces degradation, inhibiting LINE-1 retranstoposon mobilization]
• Protein Sequence: MASEMEPEVQAIDRSLLECSAEEIAGRWLQATDLNREVYQHLAHCVPKIYCRGPNPFPQKEDTLAQHILLGPMEWYICAEDPALGFPKLEQANKPSHLCGRVFKVGEPTYSCRDCAVDPTCVLCMECFLGSIHRDHRYRMTTSGGGGFCDCGDTEAWKEGPYCQKHKLSSSEVVEEEDPLVHLSEDVIARTYNIFAIMFRYAVDILTWEKESELPEDLEVAEKSDTYYCMLFNDEVHTYEQVIYTLQKAVNCTQKEAIGFATTVDRDGRRSVRYGDFQYCDQAKTVIVRNTSRQTKPLKVQVMHSSVAAHQNFGLKALSWLGSVIGYSDGLRRILCQVGLQEGPDGENSSLVDRLMLNDSKLWKGARSVYHQLFMSSLLMDLKYKKLFALRFAKNYRQLQRDFMEDDHERAVSVTALSVQFFTAPTLARMLLTEENLMTVIIKAFMDHLKHRDAQGRFQFERYTALQAFKFRRVQSLILDLKYVLISKPTEWSDELRQKFLQGFDAFLELLKCMQGMDPITRQVGQHIEMEPEWEAAFTLQMKLTHVISMVQDWCALDEKVLIEAYKKCLAVLTQCHGGFTDGEQPITLSICGHSVETIRYCVSQEKVSIHLPISRLLAGLHVLLSKSEVAYKFPELLPLSELSPPMLIEHPLRCLVLCAQVHAGMWRRNGFSLVNQIYYYHNVKCRREMFDKDIVMLQTGVSMMDPNHFLMIMLSRFELYQLFSTPDYGKRFSSEVTHKDVVQQNNTLIEEMLYLIIMLVGERFNPGVGQVAATDEIKREIIHQLSIKPMAHSELVKSLPEDENKETGMESVIESVAHFKKPGLTGRGMYELKPECAKEFNLYFYHFSRAEQSKAEEAQRKLKRENKEDTALPPPALPPFCPLFASLVNILQCDVMLYIMGTILQWAVEHHGSAWSESMLQRVLHLIGMALQEEKHHLENAVEGHVQTFTFTQKISKPGDAPHNSPSILAMLETLQNAPSLEAHKDMIRWLLKMFNAIKKIRECSSSSPVAEAEGTIMEESSRDKDKAERKRKAEIARLRREKIMAQMSEMQRHFIDENKELFQQTLELDTSASATLDSSPPVSDAALTALGPAQTQVPEPRQFVTCILCQEEQEVTVGSRAMVLAAFVQRSTVLSKDRTKTIADPEKYDPLFMHPDLSCGTHTGSCGHVMHAHCWQRYFDSVQAKEQRRQQRLRLHTSYDVENGEFLCPLCECLSNTVIPLLLPPRSILSRRLNFSDQPDLAQWTRAVTQQIKVVQMLRRKHNAADTSSSEDTEAMNIIPIPEGFRPDFYPRNPYSDSIKEMLTTFGTAAYKVGLKVHPNEGDPRVPILCWGTCAYTIQSIERILSDEEKPVFGPLPCRLDDCLRSLTRFAAAHWTVALLPVVQGHFCKLFASLVPSDSYEDLPCILDIDMFHLLVGLVLAFPALQCQDFSGSSLATGDLHIFHLVTMAHIVQILLTSCTEENGMDQENPTGEEELAILSLHKTLHQYTGSALKEAPSGWHLWRSVRAAIMPFLKCSALFFHYLNGVPAPPDLQVSGTSHFEHLCNYLSLPTNLIHLFQENSDIMNSLIESWCQNSEVKRYLNGERGAISYPRGANKLIDLPEDYSSLINQASNFSCPKSGGDKSRAPTLCLVCGSLLCSQSYCCQAELEGEDVGACTAHTYSCGSGAGIFLRVRECQVLFLAGKTKGCFYSPPYLDDYGETDQGLRRGNPLHLCQERFRKIQKLWQQHSITEEIGHAQEANQTLVGIDWQHL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MASEMEPEV ------CCCCCCHHH	26.04	-
15	Phosphorylation	EVQAIDRSLLECSAE HHHHHHHHHHHCCHH	33.29	28066266
169	Phosphorylation	YCQKHKLSSSEVVEE CCCCCCCCCCCCCCC	36.30	25293948
170	Phosphorylation	CQKHKLSSSEVVEEE CCCCCCCCCCCCCCC	40.74	25293948
171	Phosphorylation	QKHKLSSSEVVEEED CCCCCCCCCCCCCCC	30.91	25293948
361	Ubiquitination	RLMLNDSKLWKGARS HHHHCCCHHHHHHHH	62.32	-
734	Phosphorylation	PDYGKRFSSEVTHKD CCCHHCCCCCCCHHH	29.62	24899341
735	Phosphorylation	DYGKRFSSEVTHKDV CCHHCCCCCCCHHHH	33.12	29176673
1006	Phosphorylation	IKKIRECSSSSPVAE HHHHHHCCCCCCCHH	28.62	25293948
1007	Phosphorylation	KKIRECSSSSPVAEA HHHHHCCCCCCCHHH	46.63	25293948
1008	Phosphorylation	KIRECSSSSPVAEAE HHHHCCCCCCCHHHH	23.51	25293948
1009	Phosphorylation	IRECSSSSPVAEAEG HHHCCCCCCCHHHHC	25.91	21149613
1017	Phosphorylation	PVAEAEGTIMEESSR CCHHHHCCCCCHHHC	14.51	25293948
1050	Phosphorylation	EKIMAQMSEMQRHFI HHHHHHHHHHHHHCH	20.17	29514104
1187	Ubiquitination	YFDSVQAKEQRRQQR HHHHHHHHHHHHHHH	36.97	-
1732	Phosphorylation	QKLWQQHSITEEIGH HHHHHHCCCHHHHCC	27.20	26643407
1734	Phosphorylation	LWQQHSITEEIGHAQ HHHHCCCHHHHCCHH	30.49	26643407

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of UBR2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of UBR2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of UBR2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TX19A_MOUSE	Tex19.1	physical	21103378

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.