UBR1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: UBR1_MOUSE
• UniProt AC: O70481
• Protein Name: E3 ubiquitin-protein ligase UBR1
• Gene Name: Ubr1
• Organism: Mus musculus (Mouse).
• Sequence Length: 1757
• Subcellular Localization: Cytoplasm, cytosol.
• Protein Description: E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. May be involved in pancreatic homeostasis. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth (By similarity)..
• Protein Sequence: MADEEMDGAERMDVSPEPPLAPQRPASWWDQQVDFYTAFLHHLAQLVPEIYFAEMDPDLEKQEESVQMSILTPLEWYLFGEDPDICLEKLKHSGAFQLCGKVFKSGETTYSCRDCAIDPTCVLCMDCFQSSVHKNHRYKMHTSTGGGFCDCGDTEAWKTGPFCVDHEPGRAGTTKESLHCPLNEEVIAQARRIFPSVIKYIVEMTIWEEEKELPPELQIREKNERYYCVLFNDEHHSYDHVIYSLQRALDCELAEAQLHTTAIDKEGRRAVKAGVYATCQEAKEDIKSHSENVSQHPLHVEVLHSVVMAHQKFALRLGSWMNKIMSYSSDFRQIFCQACLVEEPGSENPCLISRLMLWDAKLYKGARKILHELIFSSFFMEMEYKKLFAMEFVKYYKQLQKEYISDDHERSISITALSVQMLTVPTLARHLIEEQNVISVITETLLEVLPEYLDRNNKFNFQGYSQDKLGRVYAVICDLKYILISKPVIWTERLRAQFLEGFRSFLKILTCMQGMEEIRRQVGQHIEVDPDWEAAIAIQMQLKNILLMFQEWCACDEDLLLVAYKECHKAVMRCSTNFMSSTKTVVQLCGHSLETKSYKVSEDLVSIHLPLSRTLAGLHVRLSRLGAISRLHEFVPFDGFQVEVLVEYPLRCLVLVAQVVAEMWRRNGLSLISQVFYYQDVKCREEMYDKDIIMLQIGASIMDPNKFLLLVLQRYELTDAFNKTISTKDQDLIKQYNTLIEEMLQVLIYIVGERYVPGVGNVTREEVIMREITHLLCIEPMPHSAIARNLPENENNETGLENVINKVATFKKPGVSGHGVYELKDESLKDFNMYFYHYSKTQHSKAEHMQKKRRKQENKDEALPPPPPPEFCPAFSKVVNLLSCDVMMYILRTIFERAVDMESNLWTEGMLQMAFHILALGLLEEKQQLQKAPEEEVAFDFYHKASRLGSSAMNAQNIQMLLEKLKGIPQLESQKDMITWILQMFDTVKRLREKSCLVVATTSGLECVKSEEITHDKEKAERKRKAEAARLHRQKIMAQMSALQKNFIETHKLMYDNTSEVTGKEDSIMEEESTSAVSEASRIALGPKRGPAVTEKEVLTCILCQEEQEVKLENNAMVLSACVQKSTALTQHRGKPVDHLGETLDPLFMDPDLAHGTYTGSCGHVMHAVCWQKYFEAVQLSSQQRIHVDLFDLESGEYLCPLCKSLCNTVIPIIPLQPQKINSENAEALAQLLTLARWIQTVLARISGYNIKHAKGEAPAVPVLFNQGMGDSTFEFHSILSFGVQSSVKYSNSIKEMVILFATTIYRIGLKVPPDELDPRVPMMTWSTCAFTIQAIENLLGDEGKPLFGALQNRQHNGLKALMQFAVAQRTTCPQVLIHKHLARLLSVILPNLQSENTPGLLSVDLFHVLVGAVLAFPSLYWDDTVDLQPSPLSSSYNHLYLFHLITMAHMLQILLTTDTDLSSGPPLAEGEEDSEEARCASAFFVEVSQHTDGLAGCGAPGWYLWLSLRNGITPYLRCAALLFHYLLGVAPPEELFANSAEGEFSALCSYLSLPTNLFLLFQEYWDTIRPLLQRWCGDPALLKSLKQKSAVVRYPRKRNSLIELPEDYSCLLNQASHFRCPRSADDERKHPVLCLFCGAILCSQNICCQEIVNGEEVGACVFHALHCGAGVCIFLKIRECRVVLVEGKARGCAYPAPYLDEYGETDPGLKRGNPLHLSRERYRKLHLVWQQHCIIEEIARSQETNQMLFGFNWQLL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MADEEMDGA ------CCHHHCCCC	44.20	-
15	Phosphorylation	GAERMDVSPEPPLAP CCCCCCCCCCCCCCC	21.20	26824392
326	Phosphorylation	SWMNKIMSYSSDFRQ HHHHHHHHCCHHHHH	25.90	25195567
327	Phosphorylation	WMNKIMSYSSDFRQI HHHHHHHCCHHHHHH	8.53	25195567
328	Phosphorylation	MNKIMSYSSDFRQIF HHHHHHCCHHHHHHH	19.00	25195567
329	Phosphorylation	NKIMSYSSDFRQIFC HHHHHCCHHHHHHHH	32.32	25195567
384	Phosphorylation	SFFMEMEYKKLFAME HHHHHHHHHHHHHHH	16.47	28059163
504	Phosphorylation	QFLEGFRSFLKILTC HHHHHHHHHHHHHHH	32.44	24719451
623	Phosphorylation	AGLHVRLSRLGAISR CCHHHHHHHHCHHHH	18.20	23140645
806	Ubiquitination	GLENVINKVATFKKP HHHHHHHHHHCCCCC	23.32	22790023
889	Phosphorylation	LSCDVMMYILRTIFE HHHHHHHHHHHHHHH	4.44	29895711
944	Ubiquitination	VAFDFYHKASRLGSS HHHHHHHHHHHHCHH	36.36	22790023
1041	Phosphorylation	QKIMAQMSALQKNFI HHHHHHHHHHHHHHH	17.47	29899451
1182	Phosphorylation	FEAVQLSSQQRIHVD HHHHHCCCCCCEEEE	38.64	-
1584	Ubiquitination	CGDPALLKSLKQKSA HCCHHHHHHHHHCCC	55.37	22790023
1601	Phosphorylation	RYPRKRNSLIELPED CCCCCCCCCCCCCCC	34.45	26824392
1711	Ubiquitination	GETDPGLKRGNPLHL CCCCCCCCCCCCCCC	65.26	22790023

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of UBR1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of UBR1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of UBR1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
UBR1_MOUSE	Ubr1	physical	12391316

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.