UBP7_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: UBP7_RAT
• UniProt AC: Q4VSI4
• Protein Name: Ubiquitin carboxyl-terminal hydrolase 7
• Gene Name: Usp7
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 1103
• Subcellular Localization: Nucleus . Cytoplasm . Nucleus, PML body . Chromosome . Present in a minority of ND10 nuclear bodies. Association with ICP0/VMW110 at early times of infection leads to an increased proportion of USP7-containing ND10. Colocalizes with ATXN1 in the nucl
• Protein Description: Hydrolase that deubiquitinates target proteins such as FOXO4, p53/TP53, MDM2, ERCC6, DNMT1, UHRF1, PTEN, KMT2E/MLL5 and DAXX. [PubMed: 16111684]
• Protein Sequence: MNHQQQQQQQQKAGEQQLSEPEDMEMEAGDTDDPPRITQNPVINGNVALSDGHSNAEEDMEDDTSWRSEATFQFTVERFSRLSESVLSPPCFVRNLPWKIMVMPRFYPDRPHQKSVGFFLQCNAESDSTSWSCHAQAVLKIINYRDDDKSFSRRISHLFFHKENDWGFSNFMAWSEVTDPEKGFIDDDKVTFEVFVQADAPHGVAWDSKKHTGYVGLKNQGATCYMNSLLQTLFFTNQLRKAVYMMPTEGDDSSKSVPLALQRVFYELQHSDKPVGTKKLTKSFGWETLDSFMQHDVQELCRVLLDNVENKMKGTCVEGTIPKLFRGKMVSYIQCKEVDYRSDRREDYYDIQLSIKGKKNIFESFVDYVAVEQLDGDNKYDAGEHGLQEAEKGVKFLTLPPVLHLQLMRFMYDPQTDQNIKINDRFEFPEQLPLDEFLQKTDPKDPANYILHAVLVHSGDNHGGHYVVYLNPKGDGKWCKFDDDVVSRCTKEEAIEHNYGGHDDDLSVRHCTNAYMLVYIRESKLSEVLQAVTDHDIPQQLVERLQEEKRIEAQKRKERQEAHLYMQVQIVAEDQFCGHQGNDMYDEEKVRYTVFKVLKNSSLAEFVQSLSQTMGFPQDQIRLWPMQARSNGTKRPAMLDNEADGSKTMIELSDNENPWTIFLETVDPELAASGATLPKFDKDHDVMLFLKMYDPKTRSLNYCGHIYTPISCKIRDLLPVMCDRAGFIQDTSLILYEEVKPNLTERIQDYDVSLDKALDELMDGDIIVFQKDDPENDNSELPTAKEYFRDLYHRVDVIFCDKTIPNDPGFVVTLSNRMNYFQVAKTVAQRLNTDPMLLQFFKSQGYRDGPGNPLRHNYEGTLRDLLQFFKPRQPKKLYYQQLKMKITDFENRRSFKCIWLNSQFREEEITLYPDKHGCVRDLLEECKKAVELGDEASGRLRLLEIVSYKIIGVHQEDELLECLSPATSRTFRIEEIPLDQVNIDKENEMLITVAHFHKEVFGTFGIPFLLRIHQGEHFREVMKRIQSLLDIQEKEFEKFKFAIVMMGRHQYINEDEYEVNLKDFEPQPGNMSHPRPWLGLDHFNKAPKRSRYTYLEKAIKIHN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
19	Phosphorylation	KAGEQQLSEPEDMEM HHHHHHCCCHHHCCC	46.93	23712012
31	Phosphorylation	MEMEAGDTDDPPRIT CCCCCCCCCCCCCCC	41.19	28551015
38	Phosphorylation	TDDPPRITQNPVING CCCCCCCCCCCEECC	24.47	27097102
50	Phosphorylation	INGNVALSDGHSNAE ECCEEEECCCCCCCC	31.63	27097102
54	Phosphorylation	VALSDGHSNAEEDME EEECCCCCCCCHHCC	43.17	27097102
64	Phosphorylation	EEDMEDDTSWRSEAT CHHCCCCCCCCCCEE	42.38	27097102
65	Phosphorylation	EDMEDDTSWRSEATF HHCCCCCCCCCCEEE	27.73	27097102
156	Phosphorylation	KSFSRRISHLFFHKE CCHHHHHHHHHCCCC	16.60	28432305
256	Phosphorylation	EGDDSSKSVPLALQR CCCCCCCCHHHHHHH	30.80	22673903
273	Acetylation	YELQHSDKPVGTKKL HHHHCCCCCCCCCCH	44.62	22902405
278	Acetylation	SDKPVGTKKLTKSFG CCCCCCCCCHHHHHC	39.60	22902405
279	Ubiquitination	DKPVGTKKLTKSFGW CCCCCCCCHHHHHCH	62.32	-
323	Ubiquitination	CVEGTIPKLFRGKMV CEECCHHHHHCCCEE	57.30	-
336	Ubiquitination	MVSYIQCKEVDYRSD EEEEEEEEECCCCCC	44.38	-
753	Phosphorylation	RIQDYDVSLDKALDE HHHHCCCCHHHHHHH	28.14	30181290
825	Ubiquitination	MNYFQVAKTVAQRLN CCHHHHHHHHHHHHC	44.68	-
870	Acetylation	RDLLQFFKPRQPKKL HHHHHHHCCCCCCCH	40.35	22902405
870	Ubiquitination	RDLLQFFKPRQPKKL HHHHHHHCCCCCCCH	40.35	-
883	Ubiquitination	KLYYQQLKMKITDFE CHHHHHHHHHCCCCC	33.53	-
964	Phosphorylation	DELLECLSPATSRTF CHHHHHCCCCCCCEE	24.93	23984901
967	Phosphorylation	LECLSPATSRTFRIE HHHCCCCCCCEEEEE	23.33	23984901
968	Phosphorylation	ECLSPATSRTFRIEE HHCCCCCCCEEEEEE	31.28	23984901
1027	Phosphorylation	EVMKRIQSLLDIQEK HHHHHHHHHHHHCHH	28.64	23984901
1034	Acetylation	SLLDIQEKEFEKFKF HHHHHCHHHHHHHHE	51.86	22902405
1034	Ubiquitination	SLLDIQEKEFEKFKF HHHHHCHHHHHHHHE	51.86	-
1085	Acetylation	LGLDHFNKAPKRSRY CCCCCCCCCCCCHHH	66.19	-
1097	Acetylation	SRYTYLEKAIKIHN- HHHHHHHHHHHCCC-	53.46	-
1097	Ubiquitination	SRYTYLEKAIKIHN- HHHHHHHHHHHCCC-	53.46	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of UBP7_RAT !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
870	K	ubiquitylation	Ubiquitinated at Lys-870 (By similarity).	16328052

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of UBP7_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
UBP7_HUMAN	USP7	physical	16111684

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.