UBP40_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: UBP40_MOUSE
• UniProt AC: Q8BWR4
• Protein Name: Ubiquitin carboxyl-terminal hydrolase 40
• Gene Name: Usp40
• Organism: Mus musculus (Mouse).
• Sequence Length: 1235
• Protein Sequence: MFGNLFEEDYSSVSSSQYGRGKKLKTKGLEPPAPREFTNLSGIRNQGGTCYLSSLLQTLHFTPEFREALFSLGPEELGSLEDKDKPDAKVRIIPLQLQRLFAQLLLLDQEAASTIDLTDSFGWTNDEEMRQHDVQELNRILFSALETSLVGTSGHDLIHRLYHGTIVNQIVCKECKNISERQEDFLDLTVAVKNVSGLEDELCNMYVEEEIFDYDNLYHCGTCDRLVKAAKSAKLRKLPPFLTISLLRFNFDFVKCERYKDTSCYTFPLRINLKPFCEQSELDDMEYMYDLFSVIIHKGGCYGGHYHVYIKDVDHLGNWQCQEEISDTNVNVKAPQSEEEANDPLVVLKTILLQEEANQIPVDQLGQKLLKKTGISWNKKYRKQHGPLRKFLQLHPQIFLLSTDESTVSLLRNHLTQAPSDLQSCEQILHTLASESPGLNDDTSCPHWFDINDSKVHPIREKDITQQFQGKESAYMLFYRKATLQRPPEARANPRYRVPCHLLKEMDAANILLQMRRAECDSANSTFELHLHLGPHYRFFNGALHPAVSETESVWDLTFDKRKTLGDLRQSIFQLLECWEGDMVLSVAKRVPAGLHVYHTLDGDDLTLCEAEVADGEDIFVWNGVEVGGVQIQTGFDCEPLLLNILHLELSGEGSKCEQLVESPHVFPANAEVGAVFTALGTPAGAILMNSVESADGECWTAVPKEDMKKTFREQGLRNGSLILVQDSDSDNNSLLPKQGRWTNSMNELNWLQVKNFCQSESEEKQVQIAVTMHTVVFDIRIKAIKELKLMKELAENSCLRPIDRNGKLLCPVPDSSTLEEAEVKMGSSVGLCLGKAPTSSQLFLFFALGTDIHPGAEMDIIVEETLSVRDCLKIMLEKSGQQGEIWHLRKMDWCYEAGEPLCEEDATLKELMIRSGDTLLLTEGKLPPPGHLKMPIWWYQPARLSGHCESRDHLNCAFSQDSTWRAAPTQGAPGPEPAEVSLLYLGDMEISEEATLVELKSQALALPSVSKLAVQSTALLRVWTVESKRPSRLLRTNWRQLKEYRLGRRAELCLELLQKEEDLGPRDVLLRTQLRIPGERAYSLATDLIWDTTRGWTAGSLRQRVADFYSLPVEKIEIAKYFPEKFEWLPISSWNQQVAKRKKKKNQDTLQGGPYYLKDGDTIGIKNLLFDDNDDFSTIRDDIGKENQKRLALEKKKSREVHRAQSSDLFSNAGVPARFRGPEASLSIHVASFR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
373	Phosphorylation	GQKLLKKTGISWNKK HHHHHHHHCCCCCHH	37.85	-
465	Phosphorylation	PIREKDITQQFQGKE ECCHHHHHHHHCCHH	26.84	15851034
471	Ubiquitination	ITQQFQGKESAYMLF HHHHHCCHHHHHHHE	37.40	22790023
473	Phosphorylation	QQFQGKESAYMLFYR HHHCCHHHHHHHEEE	28.34	15851034
479	Phosphorylation	ESAYMLFYRKATLQR HHHHHHEEEECCCCC	13.77	15851034
483	Phosphorylation	MLFYRKATLQRPPEA HHEEEECCCCCCCHH	26.85	29899451
504	Ubiquitination	RVPCHLLKEMDAANI CCCHHHHCCCHHHHH	58.30	22790023
571	Phosphorylation	TLGDLRQSIFQLLEC CHHHHHHHHHHHHHH	20.95	30387612
721	Phosphorylation	EQGLRNGSLILVQDS HCCCCCCCEEEEECC	18.78	-
728	Phosphorylation	SLILVQDSDSDNNSL CEEEEECCCCCCCCC	23.17	-
730	Phosphorylation	ILVQDSDSDNNSLLP EEEECCCCCCCCCCC	46.30	-
734	Phosphorylation	DSDSDNNSLLPKQGR CCCCCCCCCCCCCCC	37.22	-
1017	Phosphorylation	VSKLAVQSTALLRVW HHHHHHHHHHEEEEE	14.73	-
1025	Phosphorylation	TALLRVWTVESKRPS HHEEEEEEECCCCHH	16.13	-
1118	Phosphorylation	SLPVEKIEIAKYFPE CCCHHHHHHHHHCHH	48.22	24719451
1207	Phosphorylation	REVHRAQSSDLFSNA HHHHHHHCCHHHHCC	25.49	26824392
1208	Phosphorylation	EVHRAQSSDLFSNAG HHHHHHCCHHHHCCC	26.67	22324799
1212	Phosphorylation	AQSSDLFSNAGVPAR HHCCHHHHCCCCCCH	32.82	26643407

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of UBP40_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of UBP40_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of UBP40_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NEST_MOUSE	Nes	physical	28148530

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Large-scale phosphorylation analysis of mouse liver.";
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1207, AND MASSSPECTROMETRY.
PubMed: 17242355