UBP35_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: UBP35_HUMAN
• UniProt AC: Q9P2H5
• Protein Name: Ubiquitin carboxyl-terminal hydrolase 35
• Gene Name: USP35
• Organism: Homo sapiens (Human).
• Sequence Length: 1018
• Protein Sequence: MDKILEAVVTSSYPVSVKQGLVRRVLEAARQPLEREQCLALLALGARLYVGGAEELPRRVGCQLLHVAGRHHPDVFAEFFSARRVLRLLQGGAGPPGPRALACVQLGLQLLPEGPAADEVFALLRREVLRTVCERPGPAACAQVARLLARHPRCVPDGPHRLLFCQQLVRCLGRFRCPAEGEEGAVEFLEQAQQVSGLLAQLWRAQPAAILPCLKELFAVISCAEEEPPSSALASVVQHLPLELMDGVVRNLSNDDSVTDSQMLTAISRMIDWVSWPLGKNIDKWIIALLKGLAAVKKFSILIEVSLTKIEKVFSKLLYPIVRGAALSVLKYMLLTFQHSHEAFHLLLPHIPPMVASLVKEDSNSGTSCLEQLAELVHCMVFRFPGFPDLYEPVMEAIKDLHVPNEDRIKQLLGQDAWTSQKSELAGFYPRLMAKSDTGKIGLINLGNTCYVNSILQALFMASDFRHCVLRLTENNSQPLMTKLQWLFGFLEHSQRPAISPENFLSASWTPWFSPGTQQDCSEYLKYLLDRLHEEEKTGTRICQKLKQSSSPSPPEEPPAPSSTSVEKMFGGKIVTRICCLCCLNVSSREEAFTDLSLAFPPPERCRRRRLGSVMRPTEDITARELPPPTSAQGPGRVGPRRQRKHCITEDTPPTSLYIEGLDSKEAGGQSSQEERIEREEEGKEERTEKEEVGEEEESTRGEGEREKEEEVEEEEEKVEKETEKEAEQEKEEDSLGAGTHPDAAIPSGERTCGSEGSRSVLDLVNYFLSPEKLTAENRYYCESCASLQDAEKVVELSQGPCYLILTLLRFSFDLRTMRRRKILDDVSIPLLLRLPLAGGRGQAYDLCSVVVHSGVSSESGHYYCYAREGAARPAASLGTADRPEPENQWYLFNDTRVSFSSFESVSNVTSFFPKDTAYVLFYRQRPREGPEAELGSSRVRTEPTLHKDLMEAISKDNILYLQEQEKEARSRAAYISALPTSPHWGRGFDEDKDEDEGSPGGCNPAGGNGGDFHRLVF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
275	Phosphorylation	SRMIDWVSWPLGKNI HHHHHHHHCCCCCCH	20.79	-
300	Phosphorylation	LAAVKKFSILIEVSL HHHHHHHHEEEEEEC	25.93	21712546
306	Phosphorylation	FSILIEVSLTKIEKV HHEEEEEECHHHHHH	19.96	21712546
357	Phosphorylation	HIPPMVASLVKEDSN CCCHHHHHHHCCCCC	23.45	24719451
410	Ubiquitination	VPNEDRIKQLLGQDA CCCHHHHHHHHCCCC	35.47	29967540
419	Phosphorylation	LLGQDAWTSQKSELA HHCCCCCCCCHHHHC	24.01	29083192
420	Phosphorylation	LGQDAWTSQKSELAG HCCCCCCCCHHHHCC	25.55	29083192
549	Phosphorylation	ICQKLKQSSSPSPPE HHHHHHHCCCCCCCC	31.06	28348404
550	Phosphorylation	CQKLKQSSSPSPPEE HHHHHHCCCCCCCCC	43.72	28348404
551	Phosphorylation	QKLKQSSSPSPPEEP HHHHHCCCCCCCCCC	34.34	28348404
553	Phosphorylation	LKQSSSPSPPEEPPA HHHCCCCCCCCCCCC	55.84	28348404
612	Phosphorylation	RCRRRRLGSVMRPTE HHHHHCCCCCCCCCC	19.18	18669648
613	Phosphorylation	CRRRRLGSVMRPTED HHHHCCCCCCCCCCC	19.82	23911959
618	Phosphorylation	LGSVMRPTEDITARE CCCCCCCCCCCCCCC	35.61	29759185
622	Phosphorylation	MRPTEDITARELPPP CCCCCCCCCCCCCCC	31.80	26434776
630	Phosphorylation	ARELPPPTSAQGPGR CCCCCCCCCCCCCCC	42.33	23312004
631	Phosphorylation	RELPPPTSAQGPGRV CCCCCCCCCCCCCCC	25.11	23312004
658	Phosphorylation	DTPPTSLYIEGLDSK CCCCCCEEEECCCCC	9.19	27642862
770	Phosphorylation	DLVNYFLSPEKLTAE HHHHHHCCHHHCCCC	22.55	27251275
775	Phosphorylation	FLSPEKLTAENRYYC HCCHHHCCCCCCEEE	42.89	27251275
780	Phosphorylation	KLTAENRYYCESCAS HCCCCCCEEECCCCC	24.85	24043423
781	Phosphorylation	LTAENRYYCESCASL CCCCCCEEECCCCCC	6.11	24043423
784	Phosphorylation	ENRYYCESCASLQDA CCCEEECCCCCCCCH	16.06	24043423
787	Phosphorylation	YYCESCASLQDAEKV EEECCCCCCCCHHHH	30.78	24043423
798	Phosphorylation	AEKVVELSQGPCYLI HHHHHHHHCCCHHHH	21.42	30257219
803	Phosphorylation	ELSQGPCYLILTLLR HHHCCCHHHHHHHHH	10.42	30257219
807	Phosphorylation	GPCYLILTLLRFSFD CCHHHHHHHHHHHCH	19.42	30257219
845	Phosphorylation	AGGRGQAYDLCSVVV CCCCCHHHHHHEEEE	11.10	24043423
849	Phosphorylation	GQAYDLCSVVVHSGV CHHHHHHEEEEECCC	25.83	24043423
854	Phosphorylation	LCSVVVHSGVSSESG HHEEEEECCCCCCCC	29.31	24043423
857	Phosphorylation	VVVHSGVSSESGHYY EEEECCCCCCCCCEE	31.73	24043423
858	Phosphorylation	VVHSGVSSESGHYYC EEECCCCCCCCCEEE	33.12	24043423
860	Phosphorylation	HSGVSSESGHYYCYA ECCCCCCCCCEEEEE	32.58	24043423
863	Phosphorylation	VSSESGHYYCYAREG CCCCCCCEEEEECCC	9.96	24043423
864	Phosphorylation	SSESGHYYCYAREGA CCCCCCEEEEECCCC	3.54	24043423
866	Phosphorylation	ESGHYYCYAREGAAR CCCCEEEEECCCCCC	7.80	24043423
937	Phosphorylation	GPEAELGSSRVRTEP CCCCCCCCCCCCCCC	27.82	28122231
938	Phosphorylation	PEAELGSSRVRTEPT CCCCCCCCCCCCCCC	32.75	28122231
948	Acetylation	RTEPTLHKDLMEAIS CCCCCCCHHHHHHHH	56.52	19827047
956	Acetylation	DLMEAISKDNILYLQ HHHHHHHHCCEEEHH	48.99	19827057
967	Ubiquitination	LYLQEQEKEARSRAA EEHHHHHHHHHHHHH	57.26	29967540
971	Phosphorylation	EQEKEARSRAAYISA HHHHHHHHHHHHHHH	33.06	25072903
975	Phosphorylation	EARSRAAYISALPTS HHHHHHHHHHHCCCC	8.40	23312004
977	Phosphorylation	RSRAAYISALPTSPH HHHHHHHHHCCCCCC	15.86	28152594
981	Phosphorylation	AYISALPTSPHWGRG HHHHHCCCCCCCCCC	56.60	25159151
982	Phosphorylation	YISALPTSPHWGRGF HHHHCCCCCCCCCCC	16.90	28152594

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of UBP35_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of UBP35_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of UBP35_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
UBP35_HUMAN	USP35	physical	25915564
STING_HUMAN	TMEM173	physical	27801882
TNIP2_HUMAN	TNIP2	physical	26348204

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-613, AND MASSSPECTROMETRY.
PubMed: 18669648