UBP30_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: UBP30_DROME
• UniProt AC: Q9W462
• Protein Name: Ubiquitin carboxyl-terminal hydrolase 30 homolog
• Gene Name: Usp30 {ECO:0000312|FlyBase:FBgn0029819}
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 558
• Subcellular Localization: Mitochondrion outer membrane .
• Protein Description: Deubiquitinating enzyme that acts as a key inhibitor of mitophagy by counteracting the action of parkin (park)..
• Protein Sequence: MESEKILMAAGVTVAAVVGAFVFWGPSGSRLRQRRGQIAGLHNFGLTCFLNTLLQAMAACPQFIAWLQLYNNASPDRKSLITSMLNTLEVVNGTHATLRGDPYSPGAVLRALNALGWVIPQEEHDAHELFHVLLTCLEEEAIRPQPLGCLSDALPTDNDDNSSLAGTATPVGGFRSFSSMAAGLGASQRIGDQPNRPSSAMLTDFLNMEYDESTSLQRLVRSEAHTPDSPASVCERDGNDRLGSVLLDAVSPGTPFGFPLVSNPDSLATPMLGGERSSRPRLPQSQQQQDEGLNRRVSSSCRSLERLHRGPGRVSIWSNMMPSQVAHPFQGAMGAQIVCNGCGSKSAVRYDKFDSITLNLPPQRRTGLSLGHLLSEYITSEDLSDVKCDSCNETTTHTKSVTFAKLPACLCIHVARTVWLPTGQVCKRKDYVHFPESLSMAPYSFVQPHLNSQAGTPWGSTMSLYSSSLPMNNGVGGGEGFGTMFPKNLYRLLAVVVHSGEANSGHFVTYRRGSLRNAHRWYYTSDTIVREVSIDEVLSVPAYLLFYDRGQQRQLNLR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
178	Phosphorylation	VGGFRSFSSMAAGLG CCCCCCHHHHHHCCC		21082442
179	Phosphorylation	GGFRSFSSMAAGLGA CCCCCHHHHHHCCCH		21082442
222	Phosphorylation	SLQRLVRSEAHTPDS HHHHHHHHCCCCCCC		22817900
226	Phosphorylation	LVRSEAHTPDSPASV HHHHCCCCCCCCHHH		25749252
229	Phosphorylation	SEAHTPDSPASVCER HCCCCCCCCHHHHCC		25749252
232	Phosphorylation	HTPDSPASVCERDGN CCCCCCHHHHCCCCC		25749252
299	Phosphorylation	GLNRRVSSSCRSLER HHHHHHHHHHHHHHH		19429919
300	Phosphorylation	LNRRVSSSCRSLERL HHHHHHHHHHHHHHH		19429919
303	Phosphorylation	RVSSSCRSLERLHRG HHHHHHHHHHHHHCC		19429919

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of UBP30_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of UBP30_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of UBP30_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MIRO_DROME	Miro	physical	14605208
MCMBP_DROME	CG3430	physical	14605208

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.