MCMBP_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MCMBP_DROME
• UniProt AC: Q9VM60
• Protein Name: Mini-chromosome maintenance complex-binding protein
• Gene Name: CG3430
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 605
• Subcellular Localization: Nucleus.
• Protein Description: Associated component of the MCM complex that acts as a regulator of DNA replication. Binds to the MCM complex during late S phase and may act by promoting the disassembly of the MCM complex from chromatin (By similarity)..
• Protein Sequence: MPCAMELPSTPDELAAQQADSAALKDLLKDPSRWHSIPLLNYTPLHKLKDQTLVRFRGMIQDMMDPEIYLERYEVKSADGSKRVQEGKYRDCLKIANGEVIDYNADGNVHGERRTMFVVSVPGLNDWSKEHEKLCCPQIDLASLGQSPSSAKKRTIVGEEEAMDVDVASETTFKRPCLKEIQKDSEPVGASKSSVLGSDYLINSPLPDRPSMACMVKVYEEFDTYQLNSLVDFVGFLSVDASLDAATLEIDDCENLSELQAAHPSPFLIPRLHAFGVQVLPHANPLLDKSLRQPTEICEETYPTHLAVHKDLRMLLKLCLFDDDLAAEYLLSHLISTVYSRSEMQSIGKFALNLCNLPKNCEAYATKLYQILELLLPASHYMPMTLVTLNTAAFAPKKDYETNKLVSGVLQLAPHTHLVLDETCMQQGKLEANGVHAVQHLAHLINNQELKCDFQYYQIDYQANIPVLVLSEGRSMLPSDFVLPINADSKAVELVDESLKAAHHYLQPSRLQQFRKYLTTARTSGFNVSEEHTEMIQQDFVDMRKANVKSNADDLHGLLVLSRLLGIARGKDTLDKETWQLATEFEAKRRQRIQSLPKSSAQLRN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
147	Phosphorylation	DLASLGQSPSSAKKR CHHHCCCCCCCCCCC	25.58	28490779
149	Phosphorylation	ASLGQSPSSAKKRTI HHCCCCCCCCCCCEE	48.45	28490779
150	Phosphorylation	SLGQSPSSAKKRTIV HCCCCCCCCCCCEEC	47.71	28490779

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MCMBP_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MCMBP_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MCMBP_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MCM5_DROME	Mcm5	physical	14605208

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-147 AND SER-150, ANDMASS SPECTROMETRY.
PubMed: 18327897