UBE2B_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: UBE2B_MOUSE
• UniProt AC: P63147
• Protein Name: Ubiquitin-conjugating enzyme E2 B
• Gene Name: Ube2b
• Organism: Mus musculus (Mouse).
• Sequence Length: 152
• Subcellular Localization: Cell membrane . Nucleus . In peripheral neurons, expressed both at the plasma membrane and in nuclei.
• Protein Description: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at 'Lys-120' to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'- and 'Lys-63'-linked polyubiquitination. Required for postreplication repair of UV-damaged DNA. Associates to the E3 ligase RAD18 to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on 'Lys-164'. May be involved in neurite outgrowth..
• Protein Sequence: MSTPARRRLMRDFKRLQEDPPVGVSGAPSENNIMQWNAVIFGPEGTPFEDGTFKLVIEFSEEYPNKPPTVRFLSKMFHPNVYADGSICLDILQNRWSPTYDVSSILTSIQSLLDEPNPNSPANSQAAQLYQENKREYEKRVSAIVEQSWNDS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSTPARRRL ------CCCHHHHHH	43.00	29895711
3	Phosphorylation	-----MSTPARRRLM -----CCCHHHHHHH	21.48	29895711
66	Acetylation	FSEEYPNKPPTVRFL CCHHCCCCCCCEEHH	48.12	23236377
142	Phosphorylation	REYEKRVSAIVEQSW HHHHHHHHHHHHHHC	19.13	25338131
152	Phosphorylation	VEQSWNDS------- HHHHCCCC-------	38.62	30635358

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of UBE2B_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of UBE2B_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of UBE2B_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RAD18_MOUSE	Rad18	physical	12509447
H2B2B_MOUSE	Hist2h2bb	physical	11929833

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.