U2A2A_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: U2A2A_ARATH
• UniProt AC: O23212
• Protein Name: Splicing factor U2af large subunit A {ECO:0000303|PubMed:24580679}
• Gene Name: U2AF65A {ECO:0000303|PubMed:24580679}
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 573
• Subcellular Localization: Nucleus .
• Protein Description: Necessary for the splicing of pre-mRNA..
• Protein Sequence: MSEFEDHEGNGTVADAIYDEENGGRDGEIEDQLDSKPKRESRDHERETSRSKDREREKGRDKDRERDSEVSRRSRDRDGEKSKERSRDKDRDHRERHHRSSRHRDHSRERGERRERGGRDDDDYRRSRDRDHDRRRDDRGGRRSRRSRSRSKDRSERRTRSRSPSKSKQRVSGFDMAPPASAMLAAGAAVTGQVPPAPPTLPGAGMFPNMFPLPTGQSFGGLSMMPIQAMTQQATRHARRVYVGGLSPTANEQSVATFFSQVMAAVGGNTAGPGDAVVNVYINHEKKFAFVEMRSVEEASNAMSLDGIIFEGAPVKVRRPSDYNPSLAATLGPSQPSPHLNLAAVGLTPGASGGLEGPDRIFVGGLPYYFTESQVRELLESFGGLKGFDLVKDRETGNSKGYAFCVYQDLSVTDIACAALNGIKMGDKTLTVRRANQGTMLQKPEQENVLLHAQQQIAFQRVMLQPGAVATTVVCLTQVVTEDELRDDEEYGDIMEDMRQEGGKFGALTNVVIPRPSPNGEPVAGLGKVFLKYADTDGSTRARFGMNGRKFGGNEVVAVYYPEDKFEQGDYGA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSEFEDHEG ------CCCCCCCCC	51.50	30407730
12	Phosphorylation	EDHEGNGTVADAIYD CCCCCCCCEECEEEE	19.27	30589143
68	Phosphorylation	DKDRERDSEVSRRSR HHHHHHHHHHHHHHH	46.23	25561503
71	Phosphorylation	RERDSEVSRRSRDRD HHHHHHHHHHHHCCC	20.23	25561503
127	Phosphorylation	DDDDYRRSRDRDHDR CCCCHHHHCCCCCCC	29.54	25561503

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of U2A2A_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of U2A2A_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of U2A2A_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
U2AFB_ARATH	U2AF35B	physical	21798944
TCP21_ARATH	AT5G08330	physical	21798944
TCP19_ARATH	AT5G51910	physical	21798944

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.