dbPTM

TTPA_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TTPA_HUMAN
UniProt AC	P49638
Protein Name	Alpha-tocopherol transfer protein
Gene Name	TTPA
Organism	Homo sapiens (Human).
Sequence Length	278
Subcellular Localization	Cytoplasm .
Protein Description	Binds alpha-tocopherol, enhances its transfer between separate membranes, and stimulates its release from liver cells. [PubMed: 7887897 Binds both phosphatidylinol 3,4-bisphosphate and phosphatidylinol 4,5-bisphosphate; the resulting conformation change is important for the release of the bound alpha-tocopherol (By similarity]
Protein Sequence	MAEARSQPSAGPQLNALPDHSPLLQPGLAALRRRAREAGVPLAPLPLTDSFLLRFLRARDFDLDLAWRLLKNYYKWRAECPEISADLHPRSIIGLLKAGYHGVLRSRDPTGSKVLIYRIAHWDPKVFTAYDVFRVSLITSELIVQEVETQRNGIKAIFDLEGWQFSHAFQITPSVAKKIAAVLTDSFPLKVRGIHLINEPVIFHAVFSMIKPFLTEKIKERIHMHGNNYKQSLLQHFPDILPLEYGGEEFSMEDICQEWTNFIMKSEDYLSSISESIQ

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
50	Phosphorylation	APLPLTDSFLLRFLR CCCCCCHHHHHHHHH	16.74	24719451
100	Phosphorylation	IGLLKAGYHGVLRSR HHHHHCCCCEECCCC	10.56	-
172	Phosphorylation	FSHAFQITPSVAKKI EEEEEECCHHHHHHH	9.95	24719451
174	Phosphorylation	HAFQITPSVAKKIAA EEEECCHHHHHHHHH	26.51	28060719
229	Phosphorylation	IHMHGNNYKQSLLQH HHHCCCCHHHHHHHH	17.88	22468782

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of TTPA_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of TTPA_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TTPA_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
A4_HUMAN	APP	physical	21832049
CKLF5_HUMAN	CMTM5	physical	25416956

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TTPA_HUMAN

Related Literatures of Post-Translational Modification