TTLL6_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TTLL6_HUMAN
• UniProt AC: Q8N841
• Protein Name: Tubulin polyglutamylase TTLL6
• Gene Name: TTLL6 {ECO:0000312|EMBL:AAH33563.1}
• Organism: Homo sapiens (Human).
• Sequence Length: 843
• Subcellular Localization: Cell projection, cilium . Cytoplasm, cytoskeleton, cilium basal body . CEP41 is required for its transport between the basal body and the cilium.
• Protein Description: Polyglutamylase which preferentially modifies alpha-tubulin. Mediates tubulin polyglutamylation in cilia. Involved in the side-chain elongation step of the polyglutamylation reaction rather than in the initiation step. Generates long side-chains. Generates polyglutamylation of CGAS, leading to impair the DNA-binding activity of CGAS..
• Protein Sequence: MPQCPTLESQEGENSEEKGDSSKEDPKETVALAFVRENPGAQNGLQNAQQQGKKKRKKKRLVINLSSCRYESVRRAAQQYGFREGGEDDDWTLYWTDYSVSLERVMEMKSYQKINHFPGMSEICRKDLLARNMSRMLKMFPKDFRFFPRTWCLPADWGDLQTYSRSRKNKTYICKPDSGCQGKGIFITRTVKEIKPGEDMICQLYISKPFIIDGFKFDLRIYVLVTSCDPLRIFVYNEGLARFATTSYSRPCTDNLDDICMHLTNYSINKHSSNFSRDAHSGSKRKLSTFSAYLEDHSYNVEQIWRDIEDVIIKTLISAHPIIRHNYHTCFPNHTLNSACFEILGFDILLDHKLKPWLLEVNHSPSFSTDSRLDKEVKDGLLYDTLVLINLESCDKKKVLEEERQRGQFLQQCCSREMRIEEAKGFRAVQLKKTETYEKENCGGFRLIYPSLNSEKYEKFFQDNNSLFQNTVASRAREEYARQLIQELRLKREKKPFQMKKKVEMQGESAGEQVRKKGMRGWQQKQQQKDKAATQASKQYIQPLTLVSYTPDLLLSVRGERKNETDSSLNQEAPTEEASSVFPKLTSAKPFSSLPDLRNINLSSSKLEPSKPNFSIKEAKSASAVNVFTGTVHLTSVETTPESTTQLSISPKSPPTLAVTASSEYSGPETDRVVSFKCKKQQTPPHLTQKKMLKSFLPTKSKSFWESPNTNWTLLKSDMNKPHLISELLTKLQLSGKLSFFPAHYNPKLGMNNLSQNPSLPGECHSRSDSSGEKRQLDVSSLLLQSPQSYNVTLRDLLVIATPAQLDPRPCRSHASAMRDPCMQDQEAYSHCLISGQKGCERS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
101	Phosphorylation	YWTDYSVSLERVMEM EEEECEEEHHHHHHC	20.69	24719451
298	Phosphorylation	SAYLEDHSYNVEQIW HHHHHHCCCCHHHHH	30.63	30257219
299	Phosphorylation	AYLEDHSYNVEQIWR HHHHHCCCCHHHHHH	21.58	30257219
454	Phosphorylation	LIYPSLNSEKYEKFF EEECCCCHHHHHHHH	40.53	29978859
466	Phosphorylation	KFFQDNNSLFQNTVA HHHCCCCHHHHHHHH	36.49	-
471	Phosphorylation	NNSLFQNTVASRARE CCHHHHHHHHHHHHH	13.48	-
480	Phosphorylation	ASRAREEYARQLIQE HHHHHHHHHHHHHHH	11.44	23403867
604	Phosphorylation	LRNINLSSSKLEPSK HHCCCCCCCCCCCCC	34.36	18452278
605	Phosphorylation	RNINLSSSKLEPSKP HCCCCCCCCCCCCCC	37.57	18452278
610	Phosphorylation	SSSKLEPSKPNFSIK CCCCCCCCCCCCCHH	51.90	22468782
615	Phosphorylation	EPSKPNFSIKEAKSA CCCCCCCCHHHCCCC	39.12	18452278
621	Phosphorylation	FSIKEAKSASAVNVF CCHHHCCCCCEEEEE	34.21	22468782
623	Phosphorylation	IKEAKSASAVNVFTG HHHCCCCCEEEEEEE	39.58	22468782
639	Phosphorylation	VHLTSVETTPESTTQ EEEEEEEECCCCCCE	45.56	22468782
648	Phosphorylation	PESTTQLSISPKSPP CCCCCEEEECCCCCC	15.94	22468782
656	Phosphorylation	ISPKSPPTLAVTASS ECCCCCCEEEEEECC	30.63	22468782
658	Phosphorylation	PKSPPTLAVTASSEY CCCCCEEEEEECCCC	10.09	-
735	Phosphorylation	LLTKLQLSGKLSFFP HHHHHHHHCCCCCCC	22.41	29978859
739	Phosphorylation	LQLSGKLSFFPAHYN HHHHCCCCCCCCCCC	28.47	29978859
745	Phosphorylation	LSFFPAHYNPKLGMN CCCCCCCCCCCCCCC	34.95	29978859
787	Phosphorylation	SSLLLQSPQSYNVTL HHHHHCCCCCCCCCH	17.74	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TTLL6_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TTLL6_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TTLL6_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.