dbPTM

TTC14_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TTC14_HUMAN
UniProt AC	Q96N46
Protein Name	Tetratricopeptide repeat protein 14
Gene Name	TTC14
Organism	Homo sapiens (Human).
Sequence Length	770
Subcellular Localization
Protein Description
Protein Sequence	MDRDLLRQSLNCHGSSLLSLLRSEQQDNPHFRSLLGSAAEPARGPPPQHPLQGRKEKRVDNIEIQKFISKKADLLFALSWKSDAPATSEINEDSEDHYAIMPPLEQFMEIPSMDRRELFFRDIERGDIVIGRISSIREFGFFMVLICLGSGIMRDIAHLEITALCPLRDVPSHSNHGDPLSYYQTGDIIRAGIKDIDRYHEKLAVSLYSSSLPPHLSGIKLGVISSEELPLYYRRSVELNSNSLESYENVMQSSLGFVNPGVVEFLLEKLGIDESNPPSLMRGLQSKNFSEDDFASALRKKQSASWALKCVKIGVDYFKVGRHVDAMNEYNKALEIDKQNVEALVARGALYATKGSLNKAIEDFELALENCPTHRNARKYLCQTLVERGGQLEEEEKFLNAESYYKKALALDETFKDAEDALQKLHKYMQKSLELREKQAEKEEKQKTKKIETSAEKLRKLLKEEKRLKKKRRKSTSSSSVSSADESVSSSSSSSSSGHKRHKKHKRNRSESSRSSRRHSSRASSNQIDQNRKDECYPVPANTSASFLNHKQEVEKLLGKQDRLQYEKTQIKEKDRCPLSSSSLEIPDDFGGRSEDPRDFYNSYKTQAGSSKTEKPYKSERHFSSRRNSSDSFCRNSEDKIYGYRRFEKDIEGRKEHYRRWEPGSVRHSTSPASSEYSWKSVEKYKKYAHSGSRDFSRHEQRYRLNTNQGEYEREDNYGEDIKTEVPEEDALSSKEHSESSVKKNLPQNLLNIFNQIAEFEKEKGNKSKN

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
33	Phosphorylation	QDNPHFRSLLGSAAE CCCHHHHHHHHHHCC	27.31	-
66	Ubiquitination	VDNIEIQKFISKKAD CCCHHHHHHHHHHHH	50.78	-
70	Ubiquitination	EIQKFISKKADLLFA HHHHHHHHHHHEEHH	47.35	-
71	Acetylation	IQKFISKKADLLFAL HHHHHHHHHHEEHHE	40.10	30593133
82	Phosphorylation	LFALSWKSDAPATSE EHHEEECCCCCCCCC	32.52	25072903
87	Phosphorylation	WKSDAPATSEINEDS ECCCCCCCCCCCCCC	26.32	25072903
88	Phosphorylation	KSDAPATSEINEDSE CCCCCCCCCCCCCCC	38.29	25072903
94	Phosphorylation	TSEINEDSEDHYAIM CCCCCCCCCCCCCCC	38.45	25072903
98	Phosphorylation	NEDSEDHYAIMPPLE CCCCCCCCCCCCCHH	15.33	25072903
112	Phosphorylation	EQFMEIPSMDRRELF HHHHCCCCCCHHHHH	38.69	25072903
134	Phosphorylation	DIVIGRISSIREFGF CEEEEEEHHHHHHCH	20.53	24719451
135	Phosphorylation	IVIGRISSIREFGFF EEEEEEHHHHHHCHH	24.24	25954137
150	Phosphorylation	MVLICLGSGIMRDIA HHHHHHCCCHHHHHH	16.52	20068231
181	Phosphorylation	SNHGDPLSYYQTGDI CCCCCCCCHHHCCHH	27.47	21406692
182	Phosphorylation	NHGDPLSYYQTGDII CCCCCCCHHHCCHHH	13.79	21406692
183	Phosphorylation	HGDPLSYYQTGDIIR CCCCCCHHHCCHHHH	9.02	21406692
185	Phosphorylation	DPLSYYQTGDIIRAG CCCCHHHCCHHHHHC	22.24	21406692
225	Phosphorylation	GIKLGVISSEELPLY CCEEEEECCCCCCCE	29.32	20068231
226	Phosphorylation	IKLGVISSEELPLYY CEEEEECCCCCCCEE	24.78	20068231
232	Phosphorylation	SSEELPLYYRRSVEL CCCCCCCEEEEEEEC	7.93	20068231
233	Phosphorylation	SEELPLYYRRSVELN CCCCCCEEEEEEECC	13.77	20068231
275	Phosphorylation	EKLGIDESNPPSLMR HHHCCCCCCCHHHHH	51.38	26270265
279	Phosphorylation	IDESNPPSLMRGLQS CCCCCCHHHHHHHHC	35.73	26270265
282	Dimethylation	SNPPSLMRGLQSKNF CCCHHHHHHHHCCCC	48.22	-
282	Methylation	SNPPSLMRGLQSKNF CCCHHHHHHHHCCCC	48.22	115372833
287	Ubiquitination	LMRGLQSKNFSEDDF HHHHHHCCCCCHHHH	49.39	-
296	Phosphorylation	FSEDDFASALRKKQS CCHHHHHHHHHHHHH	28.03	25159151
301	Ubiquitination	FASALRKKQSASWAL HHHHHHHHHHHHHHH	42.95	-
319	Ubiquitination	KIGVDYFKVGRHVDA HHCCCCHHHCCHHHH	37.23	-
332	Ubiquitination	DAMNEYNKALEIDKQ HHHHHHHHHHHHCHH	54.14	-
338	Ubiquitination	NKALEIDKQNVEALV HHHHHHCHHHHHHHH	49.81	-
354	Ubiquitination	RGALYATKGSLNKAI HHHHHHCCCCHHHHH	38.03	-
359	Ubiquitination	ATKGSLNKAIEDFEL HCCCCHHHHHHHHHH	56.91	-
379	Ubiquitination	PTHRNARKYLCQTLV CCCHHHHHHHHHHHH	39.92	-
397	Ubiquitination	GQLEEEEKFLNAESY CCHHHHHHHCCHHHH	59.43	-
403	Phosphorylation	EKFLNAESYYKKALA HHHCCHHHHHHHHHH	31.21	22468782
405	Phosphorylation	FLNAESYYKKALALD HCCHHHHHHHHHHHC	18.45	22468782
407	Ubiquitination	NAESYYKKALALDET CHHHHHHHHHHHCHH	32.29	-
416	Ubiquitination	LALDETFKDAEDALQ HHHCHHCCCHHHHHH	64.55	-
424	Ubiquitination	DAEDALQKLHKYMQK CHHHHHHHHHHHHHH	54.10	-
428 (in isoform 3)	Phosphorylation	-	8.27	21552520
431	Ubiquitination	KLHKYMQKSLELREK HHHHHHHHHHHHHHH	40.24	-
432	Phosphorylation	LHKYMQKSLELREKQ HHHHHHHHHHHHHHH	15.36	24719451
434 (in isoform 3)	Phosphorylation	-	53.52	-
449	Acetylation	KEEKQKTKKIETSAE HHHHHHHHHHHHHHH	59.81	164445
453	Phosphorylation	QKTKKIETSAEKLRK HHHHHHHHHHHHHHH	36.39	17192257
454	Phosphorylation	KTKKIETSAEKLRKL HHHHHHHHHHHHHHH	22.95	25159151
460	Acetylation	TSAEKLRKLLKEEKR HHHHHHHHHHHHHHH	69.48	164449
460	Ubiquitination	TSAEKLRKLLKEEKR HHHHHHHHHHHHHHH	69.48	-
463	Sumoylation	EKLRKLLKEEKRLKK HHHHHHHHHHHHHHH	74.41	-
463	Sumoylation	EKLRKLLKEEKRLKK HHHHHHHHHHHHHHH	74.41	-
475	Phosphorylation	LKKKRRKSTSSSSVS HHHHHHHCCCCCCCC	31.54	30576142
476	Phosphorylation	KKKRRKSTSSSSVSS HHHHHHCCCCCCCCC	35.35	30576142
477	Phosphorylation	KKRRKSTSSSSVSSA HHHHHCCCCCCCCCC	35.00	20068231
479	Phosphorylation	RRKSTSSSSVSSADE HHHCCCCCCCCCCCH	34.23	-
480	Phosphorylation	RKSTSSSSVSSADES HHCCCCCCCCCCCHH	28.15	30576142
482	Phosphorylation	STSSSSVSSADESVS CCCCCCCCCCCHHCC	23.04	30576142
483	Phosphorylation	TSSSSVSSADESVSS CCCCCCCCCCHHCCC	37.27	30576142
487	Phosphorylation	SVSSADESVSSSSSS CCCCCCHHCCCCCCC	28.04	-
489	Phosphorylation	SSADESVSSSSSSSS CCCCHHCCCCCCCCC	33.51	30576142
490	Phosphorylation	SADESVSSSSSSSSS CCCHHCCCCCCCCCH	31.89	30576142
491	Phosphorylation	ADESVSSSSSSSSSG CCHHCCCCCCCCCHH	27.08	-
492	Phosphorylation	DESVSSSSSSSSSGH CHHCCCCCCCCCHHH	35.87	-
493	Phosphorylation	ESVSSSSSSSSSGHK HHCCCCCCCCCHHHH	35.87	-
494	Phosphorylation	SVSSSSSSSSSGHKR HCCCCCCCCCHHHHH	35.87	30576142
496	Phosphorylation	SSSSSSSSSGHKRHK CCCCCCCCHHHHHHH	42.14	-
497	Phosphorylation	SSSSSSSSGHKRHKK CCCCCCCHHHHHHHH	47.03	-
510	Phosphorylation	KKHKRNRSESSRSSR HHHCCCCCCHHHHHH	45.43	29449344
512	Phosphorylation	HKRNRSESSRSSRRH HCCCCCCHHHHHHHH	32.09	29449344
513	Phosphorylation	KRNRSESSRSSRRHS CCCCCCHHHHHHHHH	31.93	29449344
515	Phosphorylation	NRSESSRSSRRHSSR CCCCHHHHHHHHHHH	30.09	29449344
516	Phosphorylation	RSESSRSSRRHSSRA CCCHHHHHHHHHHHH	32.02	29449344
520	Phosphorylation	SRSSRRHSSRASSNQ HHHHHHHHHHHHHCC	21.51	-
524	Phosphorylation	RRHSSRASSNQIDQN HHHHHHHHHCCCCCC	28.81	28102081
525	Phosphorylation	RHSSRASSNQIDQNR HHHHHHHHCCCCCCC	31.59	28102081
543	Phosphorylation	CYPVPANTSASFLNH CCCCCCCCCHHHHCC	27.98	25627689
544	Phosphorylation	YPVPANTSASFLNHK CCCCCCCCHHHHCCH	23.02	25627689
546	Phosphorylation	VPANTSASFLNHKQE CCCCCCHHHHCCHHH	29.99	25627689
551	Ubiquitination	SASFLNHKQEVEKLL CHHHHCCHHHHHHHH	47.26	-
568	Ubiquitination	QDRLQYEKTQIKEKD HHHHHHHHHCCCCCC	40.57	-
580	Phosphorylation	EKDRCPLSSSSLEIP CCCCCCCCCCCCCCC	17.20	18691976
582	Phosphorylation	DRCPLSSSSLEIPDD CCCCCCCCCCCCCCC	35.25	25627689
583	Phosphorylation	RCPLSSSSLEIPDDF CCCCCCCCCCCCCCC	31.78	25627689
629	Phosphorylation	HFSSRRNSSDSFCRN CCCCCCCCCCCCCCC	33.44	25159151
630	Phosphorylation	FSSRRNSSDSFCRNS CCCCCCCCCCCCCCC	40.60	26552605
632	Phosphorylation	SRRNSSDSFCRNSED CCCCCCCCCCCCCCC	28.35	26552605
637	Phosphorylation	SDSFCRNSEDKIYGY CCCCCCCCCCCCHHH	28.02	27134283
642	Phosphorylation	RNSEDKIYGYRRFEK CCCCCCCHHHHCCCC	17.53	-
665	Phosphorylation	YRRWEPGSVRHSTSP HHCCCCCCCCCCCCC	27.05	28450419
669	Phosphorylation	EPGSVRHSTSPASSE CCCCCCCCCCCCCCC	21.73	23927012
670	Phosphorylation	PGSVRHSTSPASSEY CCCCCCCCCCCCCCC	32.38	23927012
671	Phosphorylation	GSVRHSTSPASSEYS CCCCCCCCCCCCCCC	22.83	23401153
674	Phosphorylation	RHSTSPASSEYSWKS CCCCCCCCCCCCCCC	27.38	23927012
675	Phosphorylation	HSTSPASSEYSWKSV CCCCCCCCCCCCCCH	42.53	23927012
677	Phosphorylation	TSPASSEYSWKSVEK CCCCCCCCCCCCHHH	23.06	23403867
678	Phosphorylation	SPASSEYSWKSVEKY CCCCCCCCCCCHHHH	24.79	23403867
681	Phosphorylation	SSEYSWKSVEKYKKY CCCCCCCCHHHHHHH	29.29	21712546
688	Phosphorylation	SVEKYKKYAHSGSRD CHHHHHHHCCCCCCC	12.85	29449344
691	Phosphorylation	KYKKYAHSGSRDFSR HHHHHCCCCCCCCCH	30.23	27251275
693	Phosphorylation	KKYAHSGSRDFSRHE HHHCCCCCCCCCHHH	31.52	29449344
697	Phosphorylation	HSGSRDFSRHEQRYR CCCCCCCCHHHHHHC	36.70	29449344
703	Phosphorylation	FSRHEQRYRLNTNQG CCHHHHHHCCCCCCC	21.10	28555341
707	Phosphorylation	EQRYRLNTNQGEYER HHHHCCCCCCCCHHC	33.25	28555341
723	Sumoylation	DNYGEDIKTEVPEED CCCCCCCCCCCCHHH	51.45	28112733
724	Phosphorylation	NYGEDIKTEVPEEDA CCCCCCCCCCCHHHH	42.42	-
733	Phosphorylation	VPEEDALSSKEHSES CCHHHHHCCCCCCHH	40.87	30576142
734	Phosphorylation	PEEDALSSKEHSESS CHHHHHCCCCCCHHH	42.80	25159151

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of TTC14_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of TTC14_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TTC14_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SF3B2_HUMAN	SF3B2	physical	22365833
CHERP_HUMAN	CHERP	physical	22365833
RBM39_HUMAN	RBM39	physical	22365833
SRRM2_HUMAN	SRRM2	physical	22365833
SNW1_HUMAN	SNW1	physical	22365833
SNIP1_HUMAN	SNIP1	physical	22365833
RED_HUMAN	IK	physical	22365833
F10C1_HUMAN	FRA10AC1	physical	22365833
DGC14_HUMAN	DGCR14	physical	22365833
NKAP_HUMAN	NKAP	physical	22365833

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TTC14_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Large-scale proteomics analysis of the human kinome."; Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.; Mol. Cell. Proteomics 8:1751-1764(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-453; SER-629 ANDTHR-670, AND MASS SPECTROMETRY.	19369195 [Abstract]
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-453; SER-629; SER-669AND SER-671, AND MASS SPECTROMETRY.	18691976 [Abstract]