TTC12_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TTC12_HUMAN
• UniProt AC: Q9H892
• Protein Name: Tetratricopeptide repeat protein 12
• Gene Name: TTC12
• Organism: Homo sapiens (Human).
• Sequence Length: 705
• Protein Sequence: MDADKEKDLQKFLKNVDEISNLIQEMNSDDPVVQQKAVLETEKRLLLMEEDQEEDECRTTLNKTMISPPQTAMKSAEEINSEAFLASVEKDAKERAKRRRENKVLADALKEKGNEAFAEGNYETAILRYSEGLEKLKDMKVLYTNRAQAYMKLEDYEKALVDCEWALKCDEKCTKAYFHMGKANLALKNYSVSRECYKKILEINPKLQTQVKGYLNQVDLQEKADLQEKEAHELLDSGKNTAVTTKNLLETLSKPDQIPLFYAGGIEILTEMINECTEQTLFRMHNGFSIISDNEVIRRCFSTAGNDAVEEMVCVSVLKLWQAVCSRNEENQRVLVIHHDRARLLAALLSSKVLAIRQQSFALLLHLAQTESGRSLIINHLDLTRLLEALVSFLDFSDKEANTAMGLFTDLALEERFQVWFQANLPGVLPALTGVLKTDPKVSSSSALCQCIAIMGNLSAEPTTRRHMAACEEFGDGCLSLLARCEEDVDLFREVIYTLLGLMMNLCLQAPFVSEVWAVEVSRRCLSLLNSQDGGILTRAAGVLSRTLSSSLKIVEEALRAGVVKKMMKFLKTGGETASRYAIKILAICTNSYHEAREEVIRLDKKLSVMMKLLSSEDEVLVGNAALCLGNCMEVPNVASSLLKTDLLQVLLKLAGSDTQKTAVQVNAGIALGKLCTAEPRFAAQLRKLHGLEILNSTMKYISDS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
59	Phosphorylation	QEEDECRTTLNKTMI CCCCHHHHHHHHHCC	47.49	21712546
67	Phosphorylation	TLNKTMISPPQTAMK HHHHHCCCCCHHHCC	21.50	25159151
71	Phosphorylation	TMISPPQTAMKSAEE HCCCCCHHHCCCHHH	34.20	21712546
75	Phosphorylation	PPQTAMKSAEEINSE CCHHHCCCHHHHCHH	28.03	30622161
81	Phosphorylation	KSAEEINSEAFLASV CCHHHHCHHHHHHHH	35.64	30622161
87	Phosphorylation	NSEAFLASVEKDAKE CHHHHHHHHHHHHHH	32.72	24719451
90	Ubiquitination	AFLASVEKDAKERAK HHHHHHHHHHHHHHH	61.91	-
103	Ubiquitination	AKRRRENKVLADALK HHHHHHHHHHHHHHH	33.59	-
112	Ubiquitination	LADALKEKGNEAFAE HHHHHHHHHCHHHHC	66.50	-
122	Phosphorylation	EAFAEGNYETAILRY HHHHCCCHHHHHHHH	26.05	29978859
124	Phosphorylation	FAEGNYETAILRYSE HHCCCHHHHHHHHHH	14.50	29978859
135	Ubiquitination	RYSEGLEKLKDMKVL HHHHHHHHHCCCEEE	66.92	-
143	Phosphorylation	LKDMKVLYTNRAQAY HCCCEEEEECCHHHH	12.64	18083107
150	Phosphorylation	YTNRAQAYMKLEDYE EECCHHHHHCHHHHH	5.23	18083107
156	Phosphorylation	AYMKLEDYEKALVDC HHHCHHHHHHHHCCC	15.23	18083107
177	Phosphorylation	DEKCTKAYFHMGKAN CHHHHHHHHHCCCHH	8.79	-
206	Ubiquitination	KILEINPKLQTQVKG HHHHHCHHHHHHHHH	49.06	-
212	Ubiquitination	PKLQTQVKGYLNQVD HHHHHHHHHHHHHCC	31.83	-
223	Ubiquitination	NQVDLQEKADLQEKE HHCCHHHHHCCCHHH	33.95	-
229	Ubiquitination	EKADLQEKEAHELLD HHHCCCHHHHHHHHH	47.44	-
239	Ubiquitination	HELLDSGKNTAVTTK HHHHHCCCCCCEECH	55.89	-
545	Phosphorylation	TRAAGVLSRTLSSSL HHHHHHHHHHHHHHH	22.32	24719451
547	Phosphorylation	AAGVLSRTLSSSLKI HHHHHHHHHHHHHHH	27.84	22210691
550	Phosphorylation	VLSRTLSSSLKIVEE HHHHHHHHHHHHHHH	42.68	22210691
551	Phosphorylation	LSRTLSSSLKIVEEA HHHHHHHHHHHHHHH	30.24	22210691
572	Ubiquitination	KKMMKFLKTGGETAS HHHHHHHHCCCHHHH	48.53	-
641	Phosphorylation	EVPNVASSLLKTDLL CCCCHHHHHHHHHHH	28.16	24719451
677	Phosphorylation	IALGKLCTAEPRFAA HHHHCCCCCCHHHHH	44.48	30387612
697	Phosphorylation	HGLEILNSTMKYISD HCHHHHHHHHHHHCC	26.83	22210691
698	Phosphorylation	GLEILNSTMKYISDS CHHHHHHHHHHHCCC	19.33	22210691
701	Phosphorylation	ILNSTMKYISDS--- HHHHHHHHHCCC---	8.54	22210691
702 (in isoform 2)	Phosphorylation	-	2.84	28985074

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TTC12_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TTC12_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TTC12_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MIPO1_HUMAN	MIPOL1	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.