TSSP_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TSSP_HUMAN
• UniProt AC: Q9NQE7
• Protein Name: Thymus-specific serine protease
• Gene Name: PRSS16
• Organism: Homo sapiens (Human).
• Sequence Length: 514
• Subcellular Localization: Cytoplasmic vesicle. Vesicular, either lysosomal or endosomal.
• Protein Description: Protease that may play a role in T-cell development..
• Protein Sequence: MAVWLAQWLGPLLLVSLWGLLAPASLLRRLGEHIQQFQESSAQGLGLSLGPGAAALPKVGWLEQLLDPFNVSDRRSFLQRYWVNDQHWVGQDGPIFLHLGGEGSLGPGSVMRGHPAALAPAWGALVISLEHRFYGLSIPAGGLEMAQLRFLSSRLALADVVSARLALSRLFNISSSSPWICFGGSYAGSLAAWARLKFPHLIFASVASSAPVRAVLDFSEYNDVVSRSLMSTAIGGSLECRAAVSVAFAEVERRLRSGGAAQAALRTELSACGPLGRAENQAELLGALQALVGGVVQYDGQTGAPLSVRQLCGLLLGGGGNRSHSTPYCGLRRAVQIVLHSLGQKCLSFSRAETVAQLRSTEPQLSGVGDRQWLYQTCTEFGFYVTCENPRCPFSQLPALPSQLDLCEQVFGLSALSVAQAVAQTNSYYGGQTPGANKVLFVNGDTDPWHVLSVTQALGSSESTLLIRTGSHCLDMAPERPSDSPSLRLGRQNIFQQLQTWLKLAKESQIKGEV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
70	N-linked_Glycosylation	EQLLDPFNVSDRRSF HHHCCCCCHHHHHHH	37.46	UniProtKB CARBOHYD
162	Phosphorylation	LALADVVSARLALSR HHHHHHHHHHHHHHH	13.91	22210691
168	Phosphorylation	VSARLALSRLFNISS HHHHHHHHHHHCCCC	22.72	24719451
172	N-linked_Glycosylation	LALSRLFNISSSSPW HHHHHHHCCCCCCCE	37.51	UniProtKB CARBOHYD
257	Phosphorylation	EVERRLRSGGAAQAA HHHHHHHCCCHHHHH	46.28	20736484
321	N-linked_Glycosylation	LLLGGGGNRSHSTPY HHHCCCCCCCCCCCC	45.62	UniProtKB CARBOHYD
354	Phosphorylation	LSFSRAETVAQLRST HHCHHHHHHHHHHCC	21.84	22985185

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TSSP_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TSSP_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TSSP_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ACDSB_HUMAN	ACADSB	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.