dbPTM

TSLP_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TSLP_HUMAN
UniProt AC	Q969D9
Protein Name	Thymic stromal lymphopoietin
Gene Name	TSLP
Organism	Homo sapiens (Human).
Sequence Length	159
Subcellular Localization	Secreted .
Protein Description	Isoform 1: Cytokine that induces the release of T-cell-attracting chemokines from monocytes and, in particular, enhances the maturation of CD11c(+) dendritic cells. Can induce allergic inflammation by directly activating mast cells.; Isoform 2: May act as an antimicrobial peptide in the oral cavity and on the skin..
Protein Sequence	MFPFALLYVLSVSFRKIFILQLVGLVLTYDFTNCDFEKIKAAYLSTISKDLITYMSGTKSTEFNNTVSCSNRPHCLTEIQSLTFNPTAGCASLAKEMFAMKTKAALAIWCPGYSETQINATQAMKKRRKRKVTTNKCLEQVSQLQGLWRRFNRPLLKQQ

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Phosphorylation	MFPFALLYVLSVSFR CCCHHHHHHHHHHHH	10.53	24043423
11	Phosphorylation	FALLYVLSVSFRKIF HHHHHHHHHHHHHHH	12.98	24043423
13	Phosphorylation	LLYVLSVSFRKIFIL HHHHHHHHHHHHHHH	18.89	24719451
43	Phosphorylation	FEKIKAAYLSTISKD HHHHHHHHHHHHCHH	13.17	24114839
48	Phosphorylation	AAYLSTISKDLITYM HHHHHHHCHHHHHHH	21.87	24114839
64	N-linked_Glycosylation	GTKSTEFNNTVSCSN CCCCCEECCCCCCCC	36.71	UniProtKB CARBOHYD
119	N-linked_Glycosylation	GYSETQINATQAMKK CCCHHHCCHHHHHHH	27.41	UniProtKB CARBOHYD

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of TSLP_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of TSLP_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TSLP_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TSLP_HUMAN

Related Literatures of Post-Translational Modification