TRUA_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TRUA_MOUSE
• UniProt AC: Q9WU56
• Protein Name: tRNA pseudouridine synthase A
• Gene Name: Pus1
• Organism: Mus musculus (Mouse).
• Sequence Length: 423
• Subcellular Localization: Isoform 1: Mitochondrion.; Isoform 2: Nucleus.
• Protein Description: Converts specific uridines to PSI in a number of tRNA substrates. Acts on positions 27/28 in the anticodon stem and also positions 34 and 36 in the anticodon of an intron containing tRNA. [PubMed: 10094309 Involved in regulation of nuclear receptor activity possibly through pseudouridylation of SRA1 RNA]
• Protein Sequence: MGFPRLWAALLRNWGRWTARPGPRVPGLPPMAGNKVPPALASHQPDRKGRGGWVWEETEHPAKRVKGGEDEEPPRKLPKRKIVLLMAYSGKGYHGMQRNLGSSQFRTIEDDLVSALVQAGCIPENHGTDMRKMSFQRCARTDKGVSAAGQVVSLKVWLIDDILDKINSHLPSHIRILGLKRVTGGFNSKNKCDARTYCYMLPTFAFAHKDRDVQDESYRLSAETLQQVNRLLACYKGTHNFHNFTSQKGPREPSARRYILEMYCEEPFVREGLEFAVIKVKGQSFMMHQIRKMVGLVVAIVKGYAPESVLERSWGEEKVDVPKAPGLGLVLERVHFEKYNQRFGGDGLHEPLDWTQEEGKVTAFKEQYIYPTIVSTERDERSMAQWLNTLPIHNFSGTALGAADTGAKVPSSLEGSEGDGDTD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
18	Phosphorylation	LRNWGRWTARPGPRV HHHHCCCCCCCCCCC	16.07	27149854
103	Phosphorylation	MQRNLGSSQFRTIED HHCCCCCCCCCCHHH	31.38	22006019
134	Phosphorylation	GTDMRKMSFQRCART CCCHHHHHHHHHHCC	22.66	-
153	Phosphorylation	SAAGQVVSLKVWLID CCCCCEEEEEEHHHH	24.50	29514104
168	Phosphorylation	DILDKINSHLPSHIR HHHHHHHHCCCCCEE	29.85	21454597
172	Phosphorylation	KINSHLPSHIRILGL HHHHCCCCCEEEECE	37.60	21454597
411	Phosphorylation	DTGAKVPSSLEGSEG CCCCCCCCHHCCCCC	51.01	25619855
412	Phosphorylation	TGAKVPSSLEGSEGD CCCCCCCHHCCCCCC	25.11	25619855
416	Phosphorylation	VPSSLEGSEGDGDTD CCCHHCCCCCCCCCC	29.09	27087446
422	Phosphorylation	GSEGDGDTD------ CCCCCCCCC------	49.49	25521595

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TRUA_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TRUA_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TRUA_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RARG_MOUSE	Rarg	physical	15327771

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.