TRIML_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TRIML_HUMAN
• UniProt AC: Q8N9V2
• Protein Name: Probable E3 ubiquitin-protein ligase TRIML1
• Gene Name: TRIML1
• Organism: Homo sapiens (Human).
• Sequence Length: 468
• Protein Description: Probable E3 ubiquitin-protein ligase which plays an important role in blastocyst development..
• Protein Sequence: MSTADLMENLREELTCFICLDYFSSPVTTECGHSFCLVCLLRSWEEHNTPLSCPECWRTLEGPHFQSNERLGRLASIARQLRSQVLQSEDEQGSYGRMPTTAKALSDDEQGGSAFVAQSHGANRVHLSSEAEEHHREKLQEILNLLRVRRKEAQAVLTHEKERVKLCQEETKTCKQVVVSEYMKMHQFLKEEEQLQLQLLEQEEKENMRKLRNNEIKLTQQIRSLSKMIAQIESSSQSSAFESLEEVRGALERSEPLLLQCPEATTTELSLCRITGMKEMLRKFSTEITLDPATANAYLVLSEDLKSVKYGGSRQQLPDNPERFDQSATVLGTQIFTSGRHYWEVEVGNKTEWEVGICKDSVSRKGNLPKPPGDLFSLIGLKIGDDYSLWVSSPLKGQHVREPVCKVGVFLDYESGHIAFYNGTDESLIYSFPQASFQEALRPIFSPCLPNEGTNTDPLTICSLNSHV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSTADLMEN ------CCHHHHHHH	32.10	23403867
3	Phosphorylation	-----MSTADLMENL -----CCHHHHHHHH	23.92	25693802
67	Phosphorylation	LEGPHFQSNERLGRL CCCCCCCCCCHHHHH	39.45	30622161
94	Phosphorylation	QSEDEQGSYGRMPTT HCCCCCCCCCCCCCC	24.90	30622161
128	Phosphorylation	GANRVHLSSEAEEHH CCCCEECCHHHHHHH	15.97	-
158	Phosphorylation	KEAQAVLTHEKERVK HHHHHHHHCHHHHHH	22.76	22985185
180	Phosphorylation	TCKQVVVSEYMKMHQ HHHHHHHHHHHHHHH	16.05	27135362
226	Phosphorylation	TQQIRSLSKMIAQIE HHHHHHHHHHHHHHH	22.79	-
234	Phosphorylation	KMIAQIESSSQSSAF HHHHHHHCCCCCHHH	36.60	-
236	Phosphorylation	IAQIESSSQSSAFES HHHHHCCCCCHHHHH	43.28	-
238	Phosphorylation	QIESSSQSSAFESLE HHHCCCCCHHHHHHH	26.11	-
239	Phosphorylation	IESSSQSSAFESLEE HHCCCCCHHHHHHHH	29.37	-
327	Phosphorylation	NPERFDQSATVLGTQ CHHHHCHHHEEEEEE	27.96	25693802
329	Phosphorylation	ERFDQSATVLGTQIF HHHCHHHEEEEEEEE	22.85	25693802
377	Phosphorylation	KPPGDLFSLIGLKIG CCCCCHHHHHCEEEC	26.78	22199227

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TRIML_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TRIML_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TRIML_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
UBP5_HUMAN	USP5	physical	19156909
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.