TRIM2_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TRIM2_RAT
• UniProt AC: D3ZQG6
• Protein Name: Tripartite motif-containing protein 2
• Gene Name: Trim2
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 744
• Subcellular Localization: Cytoplasm .
• Protein Description: E3 ubiquitin-protein ligase that mediates the ubiquitination of phosphorylated BCL2L11. Also mediates the UBE2D1-dependent ubiquitination of NEFL (By similarity). Plays a neuroprotective function (By similarity). May play a role in neuronal rapid ischemic tolerance..
• Protein Sequence: MASEGASIPSPVVRQIDKQFLICSICLERYKNPKVLPCLHTFCERCLQNYIPAHSLTLSCPVCRQTSILPEKGVAALQNNFFITNLMDVLQRTPGSNGEDPSILQTVTAVAAGKPLSCPNHDGNVMEFYCQSCETAMCRECTEGEHAEHPTVPLKDVVEQHKASLQVQLDAVNKRLPEIDSALQFISEIIHQLTNQKASIVDDIHSTFDELQKTLNVRKSVLLMELEVNYGLKHKVLQSQLDTLLQGQESIKSCSNFTAQALNHGTETEVLLVKKQMSEKLNELADQDFPLHPRENDQLDFIVETEGLKKSIHNLGTILTTNAVASETVATGEGLRQTIIGQPMSVTITTKDKDGELCKTGNAYLTAELSTPDGSVADGEILDNKNGTYEFLYTVQKEGDFTLSLRLYDQHIRGSPFKLKVIRSADVSPTTEGVKRRVKSPGSGHVKQKAVKRPASMYSTGKRKENPIEDDLIFRVGTKGRNKGEFTNLQGVAASTSGKILIADSNNQCVQIFSNDGQFKSRFGIRGRSPGQLQRPTGVAVHPSGDIIIADYDNKWVSIFSNDGKFKTKIGSGKLMGPKGVSVDRNGHIIVVDNKACCVFIFQPNGKIVTRFGSRGNGDRQFAGPHFAAVNSSNEIIITDFHNHSVKVFNQEGEFMLKFGSNGEGNGQFNAPTGVAVDSNGNIIVADWGNSRIQVFDGSGSFLSYINTSADPLYGPQGLALTSDGHVVVADSGNHCFKVYRYLQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Phosphorylation	SEGASIPSPVVRQID CCCCCCCCHHHHHHC	28.76	22673903
27	Phosphorylation	FLICSICLERYKNPK HHEEHHHHHHHCCCC	3.91	-
93	Phosphorylation	LMDVLQRTPGSNGED HHHHHHHCCCCCCCC	21.02	30240740
230	Ubiquitination	LMELEVNYGLKHKVL EEEEEEHHHCCHHHH	29.07	-
278	Phosphorylation	LLVKKQMSEKLNELA EEEHHHHHHHHHHHH	29.14	22276854
360	Phosphorylation	KDGELCKTGNAYLTA CCCCEECCCCEEEEE	34.37	28551015
364	Phosphorylation	LCKTGNAYLTAELST EECCCCEEEEEEEEC	14.48	28551015
366	Phosphorylation	KTGNAYLTAELSTPD CCCCEEEEEEEECCC	12.86	27097102
370	Phosphorylation	AYLTAELSTPDGSVA EEEEEEEECCCCCCC	29.42	27097102
371	Phosphorylation	YLTAELSTPDGSVAD EEEEEEECCCCCCCC	37.71	27097102
375	Phosphorylation	ELSTPDGSVADGEIL EEECCCCCCCCCEEE	22.85	27097102
388	Phosphorylation	ILDNKNGTYEFLYTV EEECCCCEEEEEEEE	29.31	-
392	Phosphorylation	KNGTYEFLYTVQKEG CCCEEEEEEEEEECC	2.04	-
424	Phosphorylation	FKLKVIRSADVSPTT EEEEEEECCCCCCCC	20.07	30411139
428	Phosphorylation	VIRSADVSPTTEGVK EEECCCCCCCCHHHH	19.65	30411139
430	Phosphorylation	RSADVSPTTEGVKRR ECCCCCCCCHHHHHH	29.94	25403869
431	Phosphorylation	SADVSPTTEGVKRRV CCCCCCCCHHHHHHC	33.84	25403869
440	Phosphorylation	GVKRRVKSPGSGHVK HHHHHCCCCCCCCCC	31.47	28432305
441	Phosphorylation	VKRRVKSPGSGHVKQ HHHHCCCCCCCCCCH	34.94	-
443	Phosphorylation	RRVKSPGSGHVKQKA HHCCCCCCCCCCHHH	29.16	28432305
445	Phosphorylation	VKSPGSGHVKQKAVK CCCCCCCCCCHHHCC	25.87	-
456	Phosphorylation	KAVKRPASMYSTGKR HHCCCCHHHHCCCCC	22.42	28432305
458	Phosphorylation	VKRPASMYSTGKRKE CCCCHHHHCCCCCCC	10.69	27097102
459	Phosphorylation	KRPASMYSTGKRKEN CCCHHHHCCCCCCCC	23.26	28432305
460	Phosphorylation	RPASMYSTGKRKENP CCHHHHCCCCCCCCC	29.27	28432305
483	Ubiquitination	VGTKGRNKGEFTNLQ ECCCCCCCCCCCCCC	59.46	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TRIM2_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TRIM2_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TRIM2_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
B2L11_RAT	Bcl2l11	physical	21478148
B2L11_HUMAN	BCL2L11	physical	21478148

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.