TRIB3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TRIB3_MOUSE
• UniProt AC: Q8K4K2
• Protein Name: Tribbles homolog 3
• Gene Name: Trib3
• Organism: Mus musculus (Mouse).
• Sequence Length: 354
• Subcellular Localization: Nucleus .
• Protein Description: Disrupts insulin signaling by binding directly to Akt kinases and blocking their activation. May bind directly to and mask the 'Thr-308' phosphorylation site in AKT1. Binds to ATF4 and inhibits its transcriptional activation activity. Interacts with the NF-kappa-B transactivator p65 RELA and inhibits its phosphorylation and thus its transcriptional activation activity. Interacts with MAPK kinases and regulates activation of MAP kinases. May play a role in programmed neuronal cell death but does not appear to affect non-neuronal cells. Does not display kinase activity. Inhibits the transcriptional activity of DDIT3/CHOP and is involved in DDIT3/CHOP-dependent cell death during ER stress (By similarity). Can inhibit APOBEC3A editing of nuclear DNA..
• Protein Sequence: MRATPLAASADVSCRKKPLEFDDNIDAKCPVLKRVRDEPEPGPLPSLLPPSPPPASDLSPAVAPATRLGPYILLEREQGSCSYRALHCPTGTEYTCKVYPASEAQAVLAPYARLPTHQHVARPTEVLLGSRLLYIFFTKTHGDLHSLVRSRRGIPESEAAGLFRQMASAVAHCHKHGLVLRDLKLRRFVFSNCERTKLVLENLEDACVMTGSDDSLWDKHACPAYVGPEILSSRPSYSGKAADVWSLGVALFTMLAGRYPFHDSEPVLLFGKIRRGTFALPEGLSAPARCLIRCLLRKEPSERLVALGILLHPWLREDHGRVSPPQSDRREMDQVVPDGPQLEEAEEGEVGLYG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
51	Phosphorylation	LPSLLPPSPPPASDL CCCCCCCCCCCHHHC	48.36	28066266
56	Phosphorylation	PPSPPPASDLSPAVA CCCCCCHHHCCCCCC	44.87	28066266
59	Phosphorylation	PPPASDLSPAVAPAT CCCHHHCCCCCCCCC	18.79	28066266
301	Phosphorylation	CLLRKEPSERLVALG HHHCCCHHHHHHHHH	36.12	20139300

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TRIB3_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TRIB3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TRIB3_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RFWD2_MOUSE	Rfwd2	physical	20410507
ATF4_MOUSE	Atf4	physical	12749859

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.