TRAK2_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TRAK2_RAT
• UniProt AC: Q8R2H7
• Protein Name: Trafficking kinesin-binding protein 2
• Gene Name: Trak2
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 913
• Subcellular Localization: Cytoplasm. Early endosome. Mitochondrion. Colocalizes with MGARP at the mitochondria. Translocates from the cytoplasm to the mitochondria in a MGARP-dependent manner.
• Protein Description: May regulate endosome-to-lysosome trafficking of membrane cargo, including EGFR..
• Protein Sequence: MSLSQNAIFKSQTGEENLMSSNHRDSESITDVCSNEDLPEVELVNLLEEQLPQYKLRVDSLFLYENQDWSQSSHQQQDASETLSPVLAEETFRYMILGTDRVEQMTKTYNDIDMVTHLLAERDRDLELAARIGQALLKRNHVLSEQNESLEEQLGQAFDQVNQLQHELSKKEELLRIVSIASEESETDSSCSTPLRFNESFSLSQGLLQLDMMHEKLKELEEENMALRSKACHIKTETFTYEEKEQKLINDCVNELRETNAQMSRMTEELSGKSDELLRYQEEISSLLSQIVDLQHKLKEHVIEKEELRLHLQASKDAQRQLTMELHELQDRNMECLGMLHESQEEIKELRNKAGPSAHLCFSQAYGVFAGESLAAEIEGTMRKKLSLDEESVFKQKAQQKRVFDTVKVANDTRGRSVTFPVLLPIPGSNRSSVIMTAKPFESGVQQTEDKTLPNQGSSTEVPGNSHPRDPPGLPEDSDLATALHRLSLRRQNYLSEKQFFAEEWERKLQILAEQEEEVSSCEALTENLASFCTDQSETTELGSAGCLRGFMPEKLQIVKPLEGSQTLHHWQQLAQPNLGTILDPRPGVITKGFTQMPKDAVYHISDLEEDEEVGITFQVQQPLQLEQKPAPPPPVTGIFLPPMTSAGGPVSVATSNPGKCLSFTNSTFTFTTCRILHPSDITQVTPSSGFPSLSCGSSAGSASNTAVNSPAASYRLSIGESITNRRDSTITFSSTRSLAKLLQERGISAKVYHSPASENPLLQLRPKALATPSTPPNSPSQSPCSSPVPFEPRVHVSENFLASRPAETFLQEMYGLRPSRAPPDVGQLKMNLVDRLKRLGIARVVKTPVPRENGKSREAEMGLQKPDSAVYLNSGGSLLGGLRRNQSLPVMMGSFGAPVCTTSPKMGILKED

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
189	Phosphorylation	SEESETDSSCSTPLR CCCCCCCCCCCCCCC	40.44	30181290
190	Phosphorylation	EESETDSSCSTPLRF CCCCCCCCCCCCCCC	18.20	30181290
192	Phosphorylation	SETDSSCSTPLRFNE CCCCCCCCCCCCCCC	34.70	22108457
193	Phosphorylation	ETDSSCSTPLRFNES CCCCCCCCCCCCCCC	30.57	30181290
200	Phosphorylation	TPLRFNESFSLSQGL CCCCCCCCCCCHHHH	22.65	30181290
202	Phosphorylation	LRFNESFSLSQGLLQ CCCCCCCCCHHHHHH	36.07	30181290
204	Phosphorylation	FNESFSLSQGLLQLD CCCCCCCHHHHHHHH	22.47	30181290
343	Phosphorylation	CLGMLHESQEEIKEL HHHHHHCCHHHHHHH	31.95	22673903
417	Phosphorylation	ANDTRGRSVTFPVLL CCCCCCCCCEEEEEE	28.47	23984901
419	Phosphorylation	DTRGRSVTFPVLLPI CCCCCCCEEEEEEEC	24.38	23984901
429	Phosphorylation	VLLPIPGSNRSSVIM EEEECCCCCCCCEEE	24.58	28432305
729	Phosphorylation	SITNRRDSTITFSST HHHCCCCCEEEEEHH	21.65	-
734	Phosphorylation	RDSTITFSSTRSLAK CCCEEEEEHHHHHHH	23.34	25575281
735	Phosphorylation	DSTITFSSTRSLAKL CCEEEEEHHHHHHHH	24.53	25575281
736	Phosphorylation	STITFSSTRSLAKLL CEEEEEHHHHHHHHH	24.07	25575281
772	Phosphorylation	LRPKALATPSTPPNS CCCCCCCCCCCCCCC	20.72	27097102
774	Phosphorylation	PKALATPSTPPNSPS CCCCCCCCCCCCCCC	49.55	27097102
775	Phosphorylation	KALATPSTPPNSPSQ CCCCCCCCCCCCCCC	43.92	27097102
779	Phosphorylation	TPSTPPNSPSQSPCS CCCCCCCCCCCCCCC	31.53	27097102
781	Phosphorylation	STPPNSPSQSPCSSP CCCCCCCCCCCCCCC	43.01	27097102
783	Phosphorylation	PPNSPSQSPCSSPVP CCCCCCCCCCCCCCC	32.01	27097102
786	Phosphorylation	SPSQSPCSSPVPFEP CCCCCCCCCCCCCCC	40.85	27097102
787	Phosphorylation	PSQSPCSSPVPFEPR CCCCCCCCCCCCCCE	36.31	27097102
798	Phosphorylation	FEPRVHVSENFLASR CCCEECCCCCCHHCC	16.37	25575281
804	Phosphorylation	VSENFLASRPAETFL CCCCCHHCCCHHHHH	40.73	25575281
809	Phosphorylation	LASRPAETFLQEMYG HHCCCHHHHHHHHHC	31.58	25575281
815	Phosphorylation	ETFLQEMYGLRPSRA HHHHHHHHCCCCCCC	16.56	25575281
820	Phosphorylation	EMYGLRPSRAPPDVG HHHCCCCCCCCCCHH	34.34	25575281
888	Phosphorylation	GGLRRNQSLPVMMGS HHHHCCCCCCEEEEC	37.88	27097102
895	Phosphorylation	SLPVMMGSFGAPVCT CCCEEEECCCCCCCC	11.56	27097102

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TRAK2_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TRAK2_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TRAK2_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
OGT1_RAT	Ogt	physical	12435728
HGS_RAT	Hgs	physical	17062640

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.