TRAD1_MOUSE - dbPTM
TRAD1_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TRAD1_MOUSE
UniProt AC Q3UDK1
Protein Name TRAF-type zinc finger domain-containing protein 1
Gene Name Trafd1
Organism Mus musculus (Mouse).
Sequence Length 580
Subcellular Localization
Protein Description Negative feedback regulator that controls excessive innate immune responses. Regulates both Toll-like receptor 4 (TLR4) and DDX58/RIG1-like helicases (RLH) pathways. May inhibit the LTR pathway by direct interaction with TRAF6 and attenuation of NF-kappa-B activation. May negatively regulate the RLH pathway downstream from MAVS and upstream of NF-kappa-B and IRF3..
Protein Sequence MAEFRDDQASRLCDNCKKEIPVFNFTIHEIHCQRNIGVCPVCKEPFPKSDMDIHMAAEHCQVTCKCNKKLEKRQLKQHAETECPLRLAVCQHCDLELSVVKLKEHEDYCGARTELCGSCGRNVLVKELKTHPEVCGRVEEEKRTEAAIPPEAYDEPWSQDRIWIASQLLRQIEALDPPMRLPGRPLQAFEADPFYSRTTSQRSMAAQFPVQNNLFEEQERQERNRSRQSPKDSAENNAHLDFMLALSLQNEGQATSMVEQGFWESVPEADPARAGPTSLGDIKGAADEILLPCEFCEELYPEELLIDHQTSCNPSHALRSLNTGSSSIRGVEDPGTIFQNFLQQATSNQFDTLMGLSSSAAVEDSIIIPCEFCGVQLEEEVLFYHQDQCDQRPATANHRAVEGIPAQDSQPENTSAELSRRRVKHQGDLSSGYMDDVKPESVKGPTYSMSPNRTMNNVASCNRLLNLPSGPRSDCQRSPPGVLKLNNSDSQDIRGQMRGSQNGPIASGHAPVIHSIQNLYPENFAPSFPHGSPGRYGAGGRSEGGRSSRVSPAAAGYHSRAAKAKPPKQQGAGDAEEEEE
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Acetylation------MAEFRDDQA
------CCCCCHHHH		25.32-
103UbiquitinationELSVVKLKEHEDYCG
EEEEEECCCCCCCCC		51.8422790023
118PhosphorylationARTELCGSCGRNVLV
HHHHCCCHHCCCHHH		16.64-
129UbiquitinationNVLVKELKTHPEVCG
CHHHHHHHHCHHHHC		45.97-
229PhosphorylationERNRSRQSPKDSAEN
HHHHHCCCCCHHHHH		32.5727149854
277PhosphorylationDPARAGPTSLGDIKG
CHHHCCCCCHHHHCC		35.3529472430
278PhosphorylationPARAGPTSLGDIKGA
HHHCCCCCHHHHCCC		33.2226824392
320PhosphorylationNPSHALRSLNTGSSS
CHHHHHHHCCCCCCC		27.16-
326PhosphorylationRSLNTGSSSIRGVED
HHCCCCCCCCCCCCC		31.00-
327PhosphorylationSLNTGSSSIRGVEDP
HCCCCCCCCCCCCCC		20.29-
409PhosphorylationEGIPAQDSQPENTSA
CCCCCCCCCCCCCHH		35.2430635358
414PhosphorylationQDSQPENTSAELSRR
CCCCCCCCHHHHHHH		27.8730635358
415PhosphorylationDSQPENTSAELSRRR
CCCCCCCHHHHHHHH		31.1830635358
419PhosphorylationENTSAELSRRRVKHQ
CCCHHHHHHHHHCCC		18.4230635358
424UbiquitinationELSRRRVKHQGDLSS
HHHHHHHCCCCCCCC		28.53-
430PhosphorylationVKHQGDLSSGYMDDV
HCCCCCCCCCCCCCC		26.8522345495
431PhosphorylationKHQGDLSSGYMDDVK
CCCCCCCCCCCCCCC		41.0422345495
433PhosphorylationQGDLSSGYMDDVKPE
CCCCCCCCCCCCCCH		10.1822345495
438AcetylationSGYMDDVKPESVKGP
CCCCCCCCCHHCCCC		50.4915608041
441PhosphorylationMDDVKPESVKGPTYS
CCCCCCHHCCCCCCC		37.3422345495
443UbiquitinationDVKPESVKGPTYSMS
CCCCHHCCCCCCCCC		69.3322790023
446PhosphorylationPESVKGPTYSMSPNR
CHHCCCCCCCCCCCC		36.5826643407
447PhosphorylationESVKGPTYSMSPNRT
HHCCCCCCCCCCCCC		12.9029472430
448PhosphorylationSVKGPTYSMSPNRTM
HCCCCCCCCCCCCCC		18.4322324799
450PhosphorylationKGPTYSMSPNRTMNN
CCCCCCCCCCCCCCC		17.0623527152
469PhosphorylationNRLLNLPSGPRSDCQ
HHHHCCCCCCCHHCC		65.67-
473PhosphorylationNLPSGPRSDCQRSPP
CCCCCCCHHCCCCCC		45.9625266776
478PhosphorylationPRSDCQRSPPGVLKL
CCHHCCCCCCCCEEC		15.0126824392
484UbiquitinationRSPPGVLKLNNSDSQ
CCCCCCEECCCCCCC		46.9222790023
527PhosphorylationYPENFAPSFPHGSPG
CCCCCCCCCCCCCCC		48.2426160508
527 (in isoform 2)Phosphorylation-48.2426160508
532 (in isoform 2)Phosphorylation-22.5826160508
532PhosphorylationAPSFPHGSPGRYGAG
CCCCCCCCCCCCCCC		22.5826160508
535 (in isoform 2)Phosphorylation-30.0526160508
547 (in isoform 2)Phosphorylation-26.2727566939
551PhosphorylationGGRSSRVSPAAAGYH
CCCCCCCCHHHHCHH		14.0125266776
557PhosphorylationVSPAAAGYHSRAAKA
CCHHHHCHHHHCCCC		7.5929514104
559PhosphorylationPAAAGYHSRAAKAKP
HHHHCHHHHCCCCCC		18.3525338131
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of TRAD1_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TRAD1_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TRAD1_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
TRAF6_MOUSETraf6physical
16221674
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TRAD1_MOUSE

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Related Literatures of Post-Translational Modification

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