TPPP_BOVIN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TPPP_BOVIN
• UniProt AC: Q27957
• Protein Name: Tubulin polymerization-promoting protein
• Gene Name: TPPP
• Organism: Bos taurus (Bovine).
• Sequence Length: 218
• Subcellular Localization: Cytoplasm. Cytoplasm, cytoskeleton. Nucleus.
• Protein Description: May play a role in the polymerization of tubulin into microtubules, microtubule bundling and the stabilization of existing microtubules, thus maintaining the integrity of the microtubule network. May play a role in mitotic spindle assembly and nuclear envelope breakdown..
• Protein Sequence: MADSRPKPANKTPPKSPGEPAKDKAAKRLSLEAEGAGEGAAAAGAELSALEEAFRKFAVHGDARASGREMHGKNWSKLCRDCQVIDGRSVTVTDVDIVFSKIKGKSCRTITFEQFKEALEELAKKRFKDKSAEEAVREVHKLIEGKAPIISGVTKAISSPTVSRLTDTSKFTGSHKERFDPSGRGKGRAGRVDLVDESGYVPGYKHAGTYDQKVQGGK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Phosphorylation	RPKPANKTPPKSPGE CCCCCCCCCCCCCCC	44.63	17693641
16	Phosphorylation	ANKTPPKSPGEPAKD CCCCCCCCCCCCCCC	43.86	17693641
30	Phosphorylation	DKAAKRLSLEAEGAG CHHHHHHCCHHCCCC	28.35	17693641
91	Phosphorylation	VIDGRSVTVTDVDIV EECCCEEEEEEEEEE	20.95	-
106	Phosphorylation	FSKIKGKSCRTITFE EEEECCCCCCEEEHH	19.94	-
151	O-linked_Glycosylation	EGKAPIISGVTKAIS CCCCCCCCCHHHHHC	28.12	-
158	Phosphorylation	SGVTKAISSPTVSRL CCHHHHHCCCCHHHC	34.81	-
159	Phosphorylation	GVTKAISSPTVSRLT CHHHHHCCCCHHHCC	20.62	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TPPP_BOVIN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TPPP_BOVIN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TPPP_BOVIN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
G3P_BOVIN	GAPDH	physical	17027006
EF1A1_BOVIN	EEF1A1	physical	17027006

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphorylation blocks the activity of tubulin polymerization-promoting protein (TPPP): identification of sites targeted bydifferent kinases.";
Hlavanda E., Klement E., Kokai E., Kovacs J., Vincze O., Toekesi N.,Orosz F., Medzihradszky K.F., Dombradi V., Ovadi J.;
J. Biol. Chem. 282:29531-29539(2007).
Cited for: IDENTIFICATION BY MASS SPECTROMETRY, PHOSPHORYLATION AT THR-12; SER-16AND SER-30, AND INTERACTION WITH MAPK1.
PubMed: 17693641