EF1A1_BOVIN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: EF1A1_BOVIN
• UniProt AC: P68103
• Protein Name: Elongation factor 1-alpha 1
• Gene Name: EEF1A1
• Organism: Bos taurus (Bovine).
• Sequence Length: 462
• Subcellular Localization: Cytoplasm . Nucleus . Nucleus, nucleolus . Cell membrane . Colocalizes with DLC1 at actin-rich regions in the cell periphery. Translocates together with ZPR1 from the cytoplasm to the nucleus and nucleolus after treatment with mitogens. Localization
• Protein Description: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. With PARP1 and TXK, forms a complex that acts as a T helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production..
• Protein Sequence: MGKEKTHINIVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAAEMGKGSFKYAWVLDKLKAERERGITIDISLWKFETSKYYVTIIDAPGHRDFIKNMITGTSQADCAVLIVAAGVGEFEAGISKNGQTREHALLAYTLGVKQLIVGVNKMDSTEPPYSQKRYEEIVKEVSTYIKKIGYNPDTVAFVPISGWNGDNMLEPSANMPWFKGWKVTRKDGNASGTTLLEALDCILPPTRPTDKPLRLPLQDVYKIGGIGTVPVGRVETGVLKPGMVVTFAPVNVTTEVKSVEMHHEALSEALPGDNVGFNVKNVSVKDVRRGNVAGDSKNDPPMEAAGFTAQVIILNHPGQISAGYAPVLDCHTAHIACKFAELKEKIDRRSGKKLEDGPKFLKSGDAAIVDMVPGKPMCVESFSDYPPLGRFAVRDMRQTVAVGVIKAVDKKAAGAGKVTKSAQKAQKAK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Methylation	------MGKEKTHIN ------CCCCCCEEE	46.99	-
36	Methylation	YKCGGIDKRTIEKFE EECCCCCHHHHHHHH	49.90	-
36	"N6,N6,N6-trimethyllysine"	YKCGGIDKRTIEKFE EECCCCCHHHHHHHH	49.90	-
55	"N6,N6-dimethyllysine"	EMGKGSFKYAWVLDK HCCCCCEEHHHHHHH	35.44	-
55	Methylation	EMGKGSFKYAWVLDK HCCCCCEEHHHHHHH	35.44	-
79	"N6,N6,N6-trimethyllysine"	TIDISLWKFETSKYY EEEEEEEEEECCCEE	38.32	-
79	Methylation	TIDISLWKFETSKYY EEEEEEEEEECCCEE	38.32	-
165	Acetylation	TEPPYSQKRYEEIVK CCCCCCHHHHHHHHH	51.51	-
165	"N6,N6-dimethyllysine"	TEPPYSQKRYEEIVK CCCCCCHHHHHHHHH	51.51	-
165	Methylation	TEPPYSQKRYEEIVK CCCCCCHHHHHHHHH	51.51	-
172	Acetylation	KRYEEIVKEVSTYIK HHHHHHHHHHHHHHH	59.04	-
273	Acetylation	RVETGVLKPGMVVTF EEECCCCCCCEEEEE	36.80	-
300	Phosphorylation	EMHHEALSEALPGDN EHHHHHHHHHCCCCC	28.07	-
301	5-glutamyl glycerylphosphorylethanolamine	MHHEALSEALPGDNV HHHHHHHHHCCCCCC	55.89	-
301	Formation of an isopeptide bond	MHHEALSEALPGDNV HHHHHHHHHCCCCCC	55.89	-
318	"N6,N6,N6-trimethyllysine"	NVKNVSVKDVRRGNV EEEECCHHHHHCCCC	42.89	-
318	Methylation	NVKNVSVKDVRRGNV EEEECCHHHHHCCCC	42.89	-
374	Formation of an isopeptide bond	HIACKFAELKEKIDR HHHHHHHHHHHHHHH	64.60	-
374	5-glutamyl glycerylphosphorylethanolamine	HIACKFAELKEKIDR HHHHHHHHHHHHHHH	64.60	-
392	Succinylation	KKLEDGPKFLKSGDA CCCCCCCCHHCCCCE	69.71	-
392	Succinylation	KKLEDGPKFLKSGDA CCCCCCCCHHCCCCE	69.71	-
392	Acetylation	KKLEDGPKFLKSGDA CCCCCCCCHHCCCCE	69.71	-
432	Phosphorylation	AVRDMRQTVAVGVIK HHHCHHHHHHHEEEE	10.48	-
439	Acetylation	TVAVGVIKAVDKKAA HHHHEEEEECCHHHC	39.69	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
300	S	Phosphorylation	Kinase	TGFBR1	O46680	Uniprot
432	T	Phosphorylation	Kinase	PASK	-	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of EF1A1_BOVIN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of EF1A1_BOVIN !!

Protein-Protein Interaction

Oops, there are no PPI records of EF1A1_BOVIN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.