TMM62_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TMM62_HUMAN
• UniProt AC: Q0P6H9
• Protein Name: Transmembrane protein 62
• Gene Name: TMEM62
• Organism: Homo sapiens (Human).
• Sequence Length: 643
• Subcellular Localization: Membrane ; Multi-pass membrane protein .
• Protein Sequence: MAAVLALRVVAGLAAAALVAMLLEHYGLAGQPSPLPRPAPPRRPHPAPGPGDSNIFWGLQISDIHLSRFRDPGRAVDLEKFCSETIDIIQPALVLATGDLTDAKTKEQLGSRQHEVEWQTYQGILKKTRVMEKTKWLDIKGNHDAFNIPSLDSIKNYYRKYSAVRRDGSFHYVHSTPFGNYSFICVDATVNPGPKRPYNFFGILDKKKMEELLLLAKESSRSNHTIWFGHFTTSTILSPSPGIRSIMSSAIAYLCGHLHTLGGLMPVLHTRHFQGTLELEVGDWKDNRRYRIFAFDHDLFSFADLIFGKWPVVLITNPKSLLYSCGEHEPLERLLHSTHIRVLAFSLSSITSVTVKIDGVHLGQAVHVSGPIFVLKWNPRNYSSGTHNIEVIVQDSAGRSKSVHHIFSVQENNHLSFDPLASFILRTDHYIMARVLFVLIVLSQLTILIIFRYRGYPELKEPSGFINLTSFSLHVLSKINIFYYSVLLLTLYTVLGPWFFGEIIDGKFGCCFSFGIFVNGHFLQGSITFIIGILQLAFFNIPLMAYMCWSLLQRCFGHNFRSHLHQRKYLKIMPVHLLMLLLYIWQVYSCYFLYATYGTLAFLFSPLRTWLTLLTPVLIRYVWTLNSTKFGIFMVQLKSHLSS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
33	Phosphorylation	YGLAGQPSPLPRPAP HCCCCCCCCCCCCCC	31.05	24719451
153	Phosphorylation	FNIPSLDSIKNYYRK CCCCCHHHHHHHHHH	40.53	22210691
180	N-linked_Glycosylation	VHSTPFGNYSFICVD EECCCCCCEEEEEEE	29.65	19159218
354	Phosphorylation	LSSITSVTVKIDGVH HHHCCEEEEEECCEE	18.82	-
453	Phosphorylation	TILIIFRYRGYPELK HHHHHHHHCCCCCCC	9.53	29116813
467	N-linked_Glycosylation	KEPSGFINLTSFSLH CCCCCCEECCHHHHH	34.70	UniProtKB CARBOHYD
469	Phosphorylation	PSGFINLTSFSLHVL CCCCEECCHHHHHHH	24.20	29116813
562	Phosphorylation	CFGHNFRSHLHQRKY HHCCCHHHHHHHHHH	26.68	26074081
569	Phosphorylation	SHLHQRKYLKIMPVH HHHHHHHHHHHHHHH	18.54	26074081
626	N-linked_Glycosylation	IRYVWTLNSTKFGIF HHHHHHCCCCCEEEE	40.01	UniProtKB CARBOHYD

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TMM62_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TMM62_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TMM62_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NPL4_HUMAN	NPLOC4	physical	26186194
UFD1_HUMAN	UFD1L	physical	26186194
HERC3_HUMAN	HERC3	physical	26186194

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

N-linked Glycosylation

"Glycoproteomics analysis of human liver tissue by combination ofmultiple enzyme digestion and hydrazide chemistry.";
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.;
J. Proteome Res. 8:651-661(2009).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-180, AND MASSSPECTROMETRY.
PubMed: 19159218