dbPTM

TMM53_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TMM53_HUMAN
UniProt AC	Q6P2H8
Protein Name	Transmembrane protein 53
Gene Name	TMEM53
Organism	Homo sapiens (Human).
Sequence Length	277
Subcellular Localization	Membrane Single-pass membrane protein .
Protein Description
Protein Sequence	MASAELDYTIEIPDQPCWSQKNSPSPGGKEAETRQPVVILLGWGGCKDKNLAKYSAIYHKRGCIVIRYTAPWHMVFFSESLGIPSLRVLAQKLLELLFDYEIEKEPLLFHVFSNGGVMLYRYVLELLQTRRFCRLRVVGTIFDSAPGDSNLVGALRALAAILERRAAMLRLLLLVAFALVVVLFHVLLAPITALFHTHFYDRLQDAGSRWPELYLYSRADEVVLARDIERMVEARLARRVLARSVDFVSSAHVSHLRDYPTYYTSLCVDFMRNCVRC

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
23	Phosphorylation	PCWSQKNSPSPGGKE CCCCCCCCCCCCCCC	33.52	26425664
25	Phosphorylation	WSQKNSPSPGGKEAE CCCCCCCCCCCCCCC	35.68	26425664
29	Ubiquitination	NSPSPGGKEAETRQP CCCCCCCCCCCCCCC	60.72	-
58	Phosphorylation	LAKYSAIYHKRGCIV HHHHHHHEECCCEEE	10.87	-
68	Phosphorylation	RGCIVIRYTAPWHMV CCEEEEEECCCCEEE	8.98	-
69	Phosphorylation	GCIVIRYTAPWHMVF CEEEEEECCCCEEEE	19.18	25332170
85	Phosphorylation	SESLGIPSLRVLAQK CCCCCCCHHHHHHHH	27.21	24719451
217	Phosphorylation	WPELYLYSRADEVVL CCEEEEEECCCEEEH	20.56	24719451
244	Phosphorylation	ARRVLARSVDFVSSA HHHHHHHHCCCHHHH	22.04	26074081
249	Phosphorylation	ARSVDFVSSAHVSHL HHHCCCHHHHHHHHH	23.08	26074081
250	Phosphorylation	RSVDFVSSAHVSHLR HHCCCHHHHHHHHHC	19.66	26074081
254	Phosphorylation	FVSSAHVSHLRDYPT CHHHHHHHHHCCCCC	13.62	26074081

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of TMM53_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of TMM53_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TMM53_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TMM53_HUMAN

Related Literatures of Post-Translational Modification