TMM44_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TMM44_HUMAN
• UniProt AC: Q2T9K0
• Protein Name: Transmembrane protein 44
• Gene Name: TMEM44
• Organism: Homo sapiens (Human).
• Sequence Length: 475
• Subcellular Localization: Membrane ; Multi-pass membrane protein .
• Protein Sequence: MGEAPSPAPALWDWDYLDRCFARHRVCISFGLWICASSCWIAAHALLLYLRCAQKPRQDQSALCAACCLLTSLCDTVGALLARQLTIQVFTGAYLAAIDLVNFMFILFPVCGSKFKSNSDREARERKRRRQLRASVFALALPLSLGPCWALWVAVPKASATIRGPQRRLLASLLQENTEILGYLLGSVAAFGSWASRIPPLSRIAPPPTLGITTQHEIWRGQMSKPSQSPSRSPSGHWRAAAQRQVLGTEMCRGKTFPSIHLWTRLLSALAGLLYASAIVAHDQHPEYLLRATPWFLTSLGRAALDLAIIFLSCVMKSKMRQALGFAKEARESPDTQALLTCAEKEEENQENLDWVPLTTLSHCKSLRTMTAISRYMELTIEPVQQAGCSATRLPGDGQTSAGDASLQDPPSYPPVQVIRARVSSGSSSEVSSINSDLEWDPEDVNLEGSKENVELLGSQVHQDSVRTAHLSDDD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	O-linked_Glycosylation	--MGEAPSPAPALWD --CCCCCCCCCCCCC	40.52	OGP
187	Phosphorylation	ILGYLLGSVAAFGSW HHHHHHHHHHHHCHH	14.46	22210691
193	Phosphorylation	GSVAAFGSWASRIPP HHHHHHCHHHHCCCC	17.02	22210691
224	Phosphorylation	EIWRGQMSKPSQSPS HHHCCCCCCCCCCCC	33.26	-
229	Phosphorylation	QMSKPSQSPSRSPSG CCCCCCCCCCCCCCC	29.22	-
281	Ubiquitination	LYASAIVAHDQHPEY HHHHHHHHCCCCHHH	8.40	32142685
328	Ubiquitination	RQALGFAKEARESPD HHHHHHHHHHHHCCC	50.04	32142685
333	Phosphorylation	FAKEARESPDTQALL HHHHHHHCCCHHHHH	23.63	29255136
336	Phosphorylation	EARESPDTQALLTCA HHHHCCCHHHHHHHH	21.08	29255136
341	Phosphorylation	PDTQALLTCAEKEEE CCHHHHHHHHHHHHH	15.54	23312004
366	Phosphorylation	TTLSHCKSLRTMTAI HHHHHHHHHHHHHHH	28.60	-
369	O-linked_Glycosylation	SHCKSLRTMTAISRY HHHHHHHHHHHHHHH	24.94	30620550
371	O-linked_Glycosylation	CKSLRTMTAISRYME HHHHHHHHHHHHHHH	21.89	30620550
371	Phosphorylation	CKSLRTMTAISRYME HHHHHHHHHHHHHHH	21.89	29759185
377 (in isoform 6)	Phosphorylation	-	3.10	25072903
378 (in isoform 6)	Phosphorylation	-	33.55	25072903
380 (in isoform 6)	Phosphorylation	-	15.24	25072903
381 (in isoform 6)	Phosphorylation	-	9.84	25072903
382 (in isoform 6)	Phosphorylation	-	33.90	25072903
385 (in isoform 6)	Phosphorylation	-	37.81	25072903
386 (in isoform 6)	Phosphorylation	-	39.70	25072903
389 (in isoform 6)	Phosphorylation	-	2.54	25072903
425	Phosphorylation	VIRARVSSGSSSEVS EEEEEECCCCCCHHH	39.58	33259812
435	Phosphorylation	SSEVSSINSDLEWDP CCHHHCCCCCCCCCH	31.27	33259812
459	Phosphorylation	ENVELLGSQVHQDSV HHHHHHCCCCCCCCC	29.06	25159151
465	Phosphorylation	GSQVHQDSVRTAHLS CCCCCCCCCCCCCCC	13.61	14702039
468	Phosphorylation	VHQDSVRTAHLSDDD CCCCCCCCCCCCCCC	19.10	26074081
472	Phosphorylation	SVRTAHLSDDD---- CCCCCCCCCCC----	29.18	30576142

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TMM44_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TMM44_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TMM44_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
JIP4_HUMAN	SPAG9	physical	28514442
TNKS1_HUMAN	TNKS	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.