TIR_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TIR_ARATH
• UniProt AC: Q9SSN3
• Protein Name: Toll/interleukin-1 receptor-like protein
• Gene Name: TIR
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 176
• Subcellular Localization: Cytoplasm .
• Protein Description: Disease resistance protein. Resistance proteins guard the plant against pathogens that contain an appropriate avirulence protein via a direct or indirect interaction with this avirulence protein. That triggers a defense system including the hypersensitive response, which restricts the pathogen growth (By similarity)..
• Protein Sequence: MSSHTATKYDVFLSFRGHDTRHNFISFLYKELVRRSIRTFKDDKELENGQRFSPELKSPIEVSRFAVVVVSENYAASSWCLDELVTIMDFEKKGSITVMPIFYGVEPNHVRWQTGVLAEQFKKHASREDPEKVLKWRQALTNFAQLSGDCSGDDDSKLVDKIANEISNKKTIYATI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
53	Phosphorylation	LENGQRFSPELKSPI HHCCCCCCHHHCCCC		30291188
95	Phosphorylation	MDFEKKGSITVMPIF HCHHHCCCEEEEEEE		28011693
97	Phosphorylation	FEKKGSITVMPIFYG HHHCCCEEEEEEEEC		28011693

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TIR_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TIR_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TIR_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
IAA7_ARATH	IAA7	physical	22234040

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.