dbPTM

TICRR_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TICRR_HUMAN
UniProt AC	Q7Z2Z1
Protein Name	Treslin
Gene Name	TICRR
Organism	Homo sapiens (Human).
Sequence Length	1910
Subcellular Localization	Nucleus . Associates with chromatin.
Protein Description	Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loading of CDC45L onto replication origins. Required for the transition from pre-replication complex (pre-RC) to pre-initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation..
Protein Sequence	MACCHKVMLLLDTAGGAARHSRVRRAALRLLTYLSCRFGLARVHWAFKFFDSQGARSRPSRVSDFRELGSRSWEDFEEELEARLEDRAHLPGPAPRATHTHGALMETLLDYQWDRPEITSPTKPILRSSGRRLLDVESEAKEAEAALGGLVNAVFLLAPCPHSQRELLQFVSGCEAQAQRLPPTPKQVMEKLLPKRVREVMVARKITFYWVDTTEWSKLWESPDHLGYWTVCELLHHGGGTVLPSESFSWDFAQAGEMLLRSGIKLSSEPHLSPWISMLPTDATLNRLLYNSPEYEASFPRMEGMLFLPVEAGKEIQETWTVTLEPLAMHQRHFQKPVRIFLKGSVAQWSLPTSSTLGTDSWMLGSPEESTATQRLLFQQLVSRLTAEELHLVADVDPGEGRPPITGVISPLSASAMILTVCRTKEAEFQRHVLQTAVADSPRDTASLFSDVVDSILNQTHDSLADTASAASPVPEWAQQELGHTTPWSPAVVEKWFPFCNISGASSDLMESFGLLQAASANKEESSKTEGELIHCLAELYQRKSREESTIAHQEDSKKKRGVPRTPVRQKMNTMCRSLKMLNVARLNVKAQKLHPDGSPDVAGEKGIQKIPSGRTVDKLEDRGRTLRSSKPKDFKTEEELLSYIRENYQKTVATGEIMLYACARNMISTVKMFLKSKGTKELEVNCLNQVKSSLLKTSKSLRQNLGKKLDKEDKVRECQLQVFLRLEMCLQCPSINESTDDMEQVVEEVTDLLRMVCLTEDSAYLAEFLEEILRLYIDSIPKTLGNLYNSLGFVIPQKLAGVLPTDFFSDDSMTQENKSPLLSVPFLSSARRSVSGSPESDELQELRTRSAKKRRKNALIRHKSIAEVSQNLRQIEIPKVSKRATKKENSHPAPQQPSQPVKDTVQEVTKVRRNLFNQELLSPSKRSLKRGLPRSHSVSAVDGLEDKLDNFKKNKGYHKLLTKSVAETPVHKQISKRLLHRQIKGRSSDPGPDIGVVEESPEKGDEISLRRSPRIKQLSFSRTHSASFYSVSQPKSRSVQRVHSFQQDKSDQRENSPVQSIRSPKSLLFGAMSEMISPSEKGSARMKKRSRNTLDSEVPAAYQTPKKSHQKSLSFSKTTPRRISHTPQTPLYTPERLQKSPAKMTPTKQAAFKESLKDSSSPGHDSPLDSKITPQKRHTQAGEGTSLETKTPRTPKRQGTQPPGFLPNCTWPHSVNSSPESPSCPAPPTSSTAQPRRECLTPIRDPLRTPPRAAAFMGTPQNQTHQQPHVLRAARAEEPAQKLKDKAIKTPKRPGNSTVTSSPPVTPKKLFTSPLCDVSKKSPFRKSKIECPSPGELDQKEPQMSPSVAASLSCPVPSTPPELSQRATLDTVPPPPPSKVGKRCRKTSDPRRSIVECQPDASATPGVGTADSPAAPTDSRDDQKGLSLSPQSPPERRGYPGPGLRSDWHASSPLLITSDTEHVTLLSEAEHHGIGDLKSNVLSVEEGEGLRTADAEKSSLSHPGIPPSPPSCGPGSPLMPSRDVHCTTDGRQCQASAQLDNLPASAWHSTDSASPQTYEVELEMQASGLPKLRIKKIDPSSSLEAEPLSKEESSLGEESFLPALSMPRASRSLSKPEPTYVSPPCPRLSHSTPGKSRGQTYICQACTPTHGPSSTPSPFQTDGVPWTPSPKHSGKTTPDIIKDWPRRKRAVGCGAGSSSGRGEVGADLPGSLSLLESEGKDHGLELSIHRTPILEDFELEGVCQLPDQSPPRNSMPKAEEASSWGQFGLSSRKRVLLAKEEADRGAKRICDLREDSEVSKSKEGSPSWSAWQLPSTGDEEVFVSGSTPPPSCAVRSCLSASALQALTQSPLLFQGKTPSSQSKDPRDEDVDVLPSTVEDSPFSRAFSRRRPISRTYTRKKLMGTWLEDL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
13	Phosphorylation	KVMLLLDTAGGAARH HHHHHHHCCCHHHHH	27.46	30183078
21	Phosphorylation	AGGAARHSRVRRAAL CCHHHHHHHHHHHHH	27.24	30183078
63	Phosphorylation	RSRPSRVSDFRELGS CCCCCCHHHHHHHHC	29.89	30576142
70	Phosphorylation	SDFRELGSRSWEDFE HHHHHHHCCCHHHHH	35.45	30576142
72	Phosphorylation	FRELGSRSWEDFEEE HHHHHCCCHHHHHHH	36.19	30576142
96	Methylation	HLPGPAPRATHTHGA CCCCCCCCCCHHHHH	54.98	-
107	Phosphorylation	THGALMETLLDYQWD HHHHHHHHHHHHCCC	20.75	26471730
111	Phosphorylation	LMETLLDYQWDRPEI HHHHHHHHCCCCCCC	16.09	28634298
119	Phosphorylation	QWDRPEITSPTKPIL CCCCCCCCCCCHHHH	27.30	28634298
120	Phosphorylation	WDRPEITSPTKPILR CCCCCCCCCCHHHHH	35.91	26471730
122	Phosphorylation	RPEITSPTKPILRSS CCCCCCCCHHHHHCC	49.58	28634298
186	Ubiquitination	QRLPPTPKQVMEKLL HHCCCCHHHHHHHHC	58.99	33845483
207	Phosphorylation	VMVARKITFYWVDTT HHHHHEEEEEEEECC	17.44	21712546
209	Phosphorylation	VARKITFYWVDTTEW HHHEEEEEEEECCCH	8.89	21712546
290	Phosphorylation	ATLNRLLYNSPEYEA HHHHHHHHCCCCHHH	20.41	30108239
292	Phosphorylation	LNRLLYNSPEYEASF HHHHHHCCCCHHHCC	12.93	28355574
295	Phosphorylation	LLYNSPEYEASFPRM HHHCCCCHHHCCCCC	21.85	30576142
298	Phosphorylation	NSPEYEASFPRMEGM CCCCHHHCCCCCCCE	24.68	28450419
424	Ubiquitination	MILTVCRTKEAEFQR HHHHHHCCCHHHHHH	28.27	33845483
425	Ubiquitination	ILTVCRTKEAEFQRH HHHHHCCCHHHHHHH	35.26	33845483
436	Phosphorylation	FQRHVLQTAVADSPR HHHHHHHHHHCCCCH	20.95	23927012
441	Phosphorylation	LQTAVADSPRDTASL HHHHHCCCCHHHHHH	16.46	29255136
486	Phosphorylation	QQELGHTTPWSPAVV HHHHCCCCCCCHHHH	19.65	26074081
489	Phosphorylation	LGHTTPWSPAVVEKW HCCCCCCCHHHHHHH	12.27	26074081
526	Phosphorylation	ASANKEESSKTEGEL HHCCHHHHCCCHHHH	37.92	24247654
527	Phosphorylation	SANKEESSKTEGELI HCCHHHHCCCHHHHH	47.04	24247654
527	Ubiquitination	SANKEESSKTEGELI HCCHHHHCCCHHHHH	47.04	32015554
528	Ubiquitination	ANKEESSKTEGELIH CCHHHHCCCHHHHHH	60.93	32015554
557	Phosphorylation	TIAHQEDSKKKRGVP CCCCHHHHHHCCCCC	45.69	25159151
566	Phosphorylation	KKRGVPRTPVRQKMN HCCCCCCCHHHHHHH	21.77	23898821
579	Ubiquitination	MNTMCRSLKMLNVAR HHHHHHHHHHHCCEE	1.63	32015554
580	Acetylation	NTMCRSLKMLNVARL HHHHHHHHHHCCEEE	42.46	25953088
580	Ubiquitination	NTMCRSLKMLNVARL HHHHHHHHHHCCEEE	42.46	32015554
590	Acetylation	NVARLNVKAQKLHPD CCEEEEEEEHHCCCC	43.99	25953088
592	Ubiquitination	ARLNVKAQKLHPDGS EEEEEEEHHCCCCCC	43.03	29967540
593	Ubiquitination	RLNVKAQKLHPDGSP EEEEEEHHCCCCCCC	54.33	29967540
599	Phosphorylation	QKLHPDGSPDVAGEK HHCCCCCCCCCCCCC	25.88	29255136
605	Ubiquitination	GSPDVAGEKGIQKIP CCCCCCCCCCCEECC	38.07	29967540
606	Ubiquitination	SPDVAGEKGIQKIPS CCCCCCCCCCEECCC	61.47	29967540
609	Ubiquitination	VAGEKGIQKIPSGRT CCCCCCCEECCCCCC	46.42	29967540
610	Ubiquitination	AGEKGIQKIPSGRTV CCCCCCEECCCCCCC	55.45	29967540
613	Phosphorylation	KGIQKIPSGRTVDKL CCCEECCCCCCCCCH	44.36	22210691
626	Phosphorylation	KLEDRGRTLRSSKPK CHHHHCCHHCCCCCC	29.37	26074081
629	Phosphorylation	DRGRTLRSSKPKDFK HHCCHHCCCCCCCCC	45.91	26074081
630	Phosphorylation	RGRTLRSSKPKDFKT HCCHHCCCCCCCCCC	46.68	26074081
635	Ubiquitination	RSSKPKDFKTEEELL CCCCCCCCCCHHHHH	15.29	29967540
636	Ubiquitination	SSKPKDFKTEEELLS CCCCCCCCCHHHHHH	66.22	29967540
637	Phosphorylation	SKPKDFKTEEELLSY CCCCCCCCHHHHHHH	48.93	26074081
643	Phosphorylation	KTEEELLSYIRENYQ CCHHHHHHHHHHHHH	31.01	26074081
644	Phosphorylation	TEEELLSYIRENYQK CHHHHHHHHHHHHHH	12.17	26074081
677	Phosphorylation	TVKMFLKSKGTKELE HHHHHHHCCCCCEEE	38.16	20068231
680	Phosphorylation	MFLKSKGTKELEVNC HHHHCCCCCEEEHHH	25.69	20068231
680	Ubiquitination	MFLKSKGTKELEVNC HHHHCCCCCEEEHHH	25.69	29967540
681	Ubiquitination	FLKSKGTKELEVNCL HHHCCCCCEEEHHHH	69.81	29967540
691	Ubiquitination	EVNCLNQVKSSLLKT EHHHHHHHHHHHHHH	6.72	29967540
692	Ubiquitination	VNCLNQVKSSLLKTS HHHHHHHHHHHHHHC	25.27	29967540
694	Phosphorylation	CLNQVKSSLLKTSKS HHHHHHHHHHHHCHH	31.81	24719451
712	Trimethylation	NLGKKLDKEDKVREC HHHHCCCHHHHHHHH	77.56	-
712	Methylation	NLGKKLDKEDKVREC HHHHCCCHHHHHHHH	77.56	23644510
715	Trimethylation	KKLDKEDKVRECQLQ HCCCHHHHHHHHHHH	44.26	-
715	Methylation	KKLDKEDKVRECQLQ HCCCHHHHHHHHHHH	44.26	23644510
806	Phosphorylation	KLAGVLPTDFFSDDS HHCCCCCCCCCCCCC	41.08	28450419
810	Phosphorylation	VLPTDFFSDDSMTQE CCCCCCCCCCCCCCC	40.27	28450419
813	Phosphorylation	TDFFSDDSMTQENKS CCCCCCCCCCCCCCC	28.81	28450419
815	Phosphorylation	FFSDDSMTQENKSPL CCCCCCCCCCCCCCC	36.36	28450419
820	Phosphorylation	SMTQENKSPLLSVPF CCCCCCCCCCCCHHH	32.15	25159151
824	Phosphorylation	ENKSPLLSVPFLSSA CCCCCCCCHHHHHCC	35.11	28450419
829	Phosphorylation	LLSVPFLSSARRSVS CCCHHHHHCCCHHCC	23.49	28450419
830	Phosphorylation	LSVPFLSSARRSVSG CCHHHHHCCCHHCCC	28.13	28450419
834	Phosphorylation	FLSSARRSVSGSPES HHHCCCHHCCCCCCC	18.32	25159151
836	Phosphorylation	SSARRSVSGSPESDE HCCCHHCCCCCCCHH	34.50	25159151
838	Phosphorylation	ARRSVSGSPESDELQ CCHHCCCCCCCHHHH	20.28	25159151
841	Phosphorylation	SVSGSPESDELQELR HCCCCCCCHHHHHHH	39.51	25159151
851	Phosphorylation	LQELRTRSAKKRRKN HHHHHHHHHHHHHHH	43.77	-
863	Ubiquitination	RKNALIRHKSIAEVS HHHHHHHCHHHHHHH	22.63	29967540
864	Ubiquitination	KNALIRHKSIAEVSQ HHHHHHCHHHHHHHH	33.44	29967540
865	Phosphorylation	NALIRHKSIAEVSQN HHHHHCHHHHHHHHH	22.39	28355574
870	Phosphorylation	HKSIAEVSQNLRQIE CHHHHHHHHHHHHCC	12.59	23312004
891	Phosphorylation	RATKKENSHPAPQQP CCCCCCCCCCCCCCC	31.75	28555341
899	Phosphorylation	HPAPQQPSQPVKDTV CCCCCCCCCCHHHHH	42.66	-
923	Phosphorylation	LFNQELLSPSKRSLK HHCHHHCCCCHHHHH	39.49	19664994
925	Phosphorylation	NQELLSPSKRSLKRG CHHHCCCCHHHHHCC	37.01	29255136
926	Acetylation	QELLSPSKRSLKRGL HHHCCCCHHHHHCCC	49.76	25953088
928	Phosphorylation	LLSPSKRSLKRGLPR HCCCCHHHHHCCCCC	41.81	24850871
936	Phosphorylation	LKRGLPRSHSVSAVD HHCCCCCCCCCCCCC	20.41	29255136
938	Phosphorylation	RGLPRSHSVSAVDGL CCCCCCCCCCCCCCC	21.00	23401153
940	Phosphorylation	LPRSHSVSAVDGLED CCCCCCCCCCCCCHH	26.11	29255136
969	Phosphorylation	LTKSVAETPVHKQIS HCHHHHCCHHHHHHH	22.37	25849741
988	Phosphorylation	HRQIKGRSSDPGPDI HHHHCCCCCCCCCCC	48.00	23927012
989	Phosphorylation	RQIKGRSSDPGPDIG HHHCCCCCCCCCCCE	46.60	21815630
1001	Phosphorylation	DIGVVEESPEKGDEI CCEEECCCCCCCCCC	25.50	30266825
1009	Phosphorylation	PEKGDEISLRRSPRI CCCCCCCEECCCCCC	17.49	23927012
1013	Phosphorylation	DEISLRRSPRIKQLS CCCEECCCCCCEEEE	16.46	30576142
1020	Phosphorylation	SPRIKQLSFSRTHSA CCCCEEEEEECCCCC	20.77	23911959
1024	Phosphorylation	KQLSFSRTHSASFYS EEEEEECCCCCCEEE	20.98	21949786
1026	Phosphorylation	LSFSRTHSASFYSVS EEEECCCCCCEEECC	25.62	25159151
1028	Phosphorylation	FSRTHSASFYSVSQP EECCCCCCEEECCCC	27.94	28450419
1030	Phosphorylation	RTHSASFYSVSQPKS CCCCCCEEECCCCCC	12.98	29759185
1031	Phosphorylation	THSASFYSVSQPKSR CCCCCEEECCCCCCC	17.18	27080861
1033	Phosphorylation	SASFYSVSQPKSRSV CCCEEECCCCCCCCC	34.52	27080861
1037	Phosphorylation	YSVSQPKSRSVQRVH EECCCCCCCCCHHHH	36.15	-
1039	Phosphorylation	VSQPKSRSVQRVHSF CCCCCCCCCHHHHCC	29.68	-
1045	Phosphorylation	RSVQRVHSFQQDKSD CCCHHHHCCCCCCCC	23.15	23401153
1051	Phosphorylation	HSFQQDKSDQRENSP HCCCCCCCCCCCCCC	47.46	28450419
1057	Phosphorylation	KSDQRENSPVQSIRS CCCCCCCCCCCCCCC	22.99	23401153
1061	Phosphorylation	RENSPVQSIRSPKSL CCCCCCCCCCCHHHH	21.87	25159151
1064	Phosphorylation	SPVQSIRSPKSLLFG CCCCCCCCHHHHHHH	34.70	25159151
1067	Phosphorylation	QSIRSPKSLLFGAMS CCCCCHHHHHHHHHH	33.42	29396449
1074	Phosphorylation	SLLFGAMSEMISPSE HHHHHHHHHCCCCCH	24.39	29396449
1078	Phosphorylation	GAMSEMISPSEKGSA HHHHHCCCCCHHHCH	22.51	26055452
1080	Phosphorylation	MSEMISPSEKGSARM HHHCCCCCHHHCHHH	45.19	21712546
1084	Phosphorylation	ISPSEKGSARMKKRS CCCCHHHCHHHHHHC	24.62	26055452
1091	Phosphorylation	SARMKKRSRNTLDSE CHHHHHHCCCCCCCC	38.47	27282143
1094	Phosphorylation	MKKRSRNTLDSEVPA HHHHCCCCCCCCCCC	30.72	28555341
1103	Phosphorylation	DSEVPAAYQTPKKSH CCCCCCHHCCCCCCC	18.28	25159151
1105	Phosphorylation	EVPAAYQTPKKSHQK CCCCHHCCCCCCCCC	25.13	29255136
1109	Phosphorylation	AYQTPKKSHQKSLSF HHCCCCCCCCCCCCC	36.96	26055452
1113	Phosphorylation	PKKSHQKSLSFSKTT CCCCCCCCCCCCCCC	23.75	23401153
1115	Phosphorylation	KSHQKSLSFSKTTPR CCCCCCCCCCCCCCC	34.27	27422710
1117	Phosphorylation	HQKSLSFSKTTPRRI CCCCCCCCCCCCCCC	26.22	28450419
1118	Ubiquitination	QKSLSFSKTTPRRIS CCCCCCCCCCCCCCC	55.17	-
1119	Phosphorylation	KSLSFSKTTPRRISH CCCCCCCCCCCCCCC	40.61	28450419
1120	Phosphorylation	SLSFSKTTPRRISHT CCCCCCCCCCCCCCC	20.66	27422710
1125	Phosphorylation	KTTPRRISHTPQTPL CCCCCCCCCCCCCCC	21.35	25159151
1127	Phosphorylation	TPRRISHTPQTPLYT CCCCCCCCCCCCCCC	15.42	30266825
1130	Phosphorylation	RISHTPQTPLYTPER CCCCCCCCCCCCHHH	19.23	30266825
1133	Phosphorylation	HTPQTPLYTPERLQK CCCCCCCCCHHHHCC	22.81	30266825
1134	Phosphorylation	TPQTPLYTPERLQKS CCCCCCCCHHHHCCC	26.76	30266825
1141	Phosphorylation	TPERLQKSPAKMTPT CHHHHCCCCCCCCCC	19.68	23401153
1146	Phosphorylation	QKSPAKMTPTKQAAF CCCCCCCCCCHHHHH	27.40	23401153
1148	Phosphorylation	SPAKMTPTKQAAFKE CCCCCCCCHHHHHHH	26.99	22617229
1149	Acetylation	PAKMTPTKQAAFKES CCCCCCCHHHHHHHH	38.86	25953088
1156	Phosphorylation	KQAAFKESLKDSSSP HHHHHHHHHCCCCCC	41.11	20873877
1160	Phosphorylation	FKESLKDSSSPGHDS HHHHHCCCCCCCCCC	31.00	29255136
1161	Phosphorylation	KESLKDSSSPGHDSP HHHHCCCCCCCCCCC	51.16	29255136
1162	Phosphorylation	ESLKDSSSPGHDSPL HHHCCCCCCCCCCCC	38.56	29255136
1167	Phosphorylation	SSSPGHDSPLDSKIT CCCCCCCCCCCCCCC	22.99	29255136
1171	Phosphorylation	GHDSPLDSKITPQKR CCCCCCCCCCCCCCC	33.37	23401153
1174	Phosphorylation	SPLDSKITPQKRHTQ CCCCCCCCCCCCCCC	24.33	23401153
1180	Phosphorylation	ITPQKRHTQAGEGTS CCCCCCCCCCCCCCC	24.93	26270265
1186	Phosphorylation	HTQAGEGTSLETKTP CCCCCCCCCCCCCCC	26.32	26270265
1187	Phosphorylation	TQAGEGTSLETKTPR CCCCCCCCCCCCCCC	34.76	25159151
1190	Phosphorylation	GEGTSLETKTPRTPK CCCCCCCCCCCCCCC	45.57	26270265
1192	Phosphorylation	GTSLETKTPRTPKRQ CCCCCCCCCCCCCCC	25.98	28555341
1195	Phosphorylation	LETKTPRTPKRQGTQ CCCCCCCCCCCCCCC	34.07	28555341
1201	Phosphorylation	RTPKRQGTQPPGFLP CCCCCCCCCCCCCCC	29.57	28111955
1211	Phosphorylation	PGFLPNCTWPHSVNS CCCCCCCCCCCCCCC	48.98	28111955
1215	Phosphorylation	PNCTWPHSVNSSPES CCCCCCCCCCCCCCC	20.93	28111955
1218	Phosphorylation	TWPHSVNSSPESPSC CCCCCCCCCCCCCCC	45.15	28111955
1219	Phosphorylation	WPHSVNSSPESPSCP CCCCCCCCCCCCCCC	27.73	28111955
1222	Phosphorylation	SVNSSPESPSCPAPP CCCCCCCCCCCCCCC	26.04	28111955
1224	Phosphorylation	NSSPESPSCPAPPTS CCCCCCCCCCCCCCC	41.85	28111955
1230	Phosphorylation	PSCPAPPTSSTAQPR CCCCCCCCCCCCCCH	33.96	28111955
1231	Phosphorylation	SCPAPPTSSTAQPRR CCCCCCCCCCCCCHH	31.31	28111955
1232	Phosphorylation	CPAPPTSSTAQPRRE CCCCCCCCCCCCHHH	30.18	28111955
1233	Phosphorylation	PAPPTSSTAQPRREC CCCCCCCCCCCHHHH	29.13	28111955
1242	Phosphorylation	QPRRECLTPIRDPLR CCHHHHCCCCCCCCC	28.47	23663014
1250	Phosphorylation	PIRDPLRTPPRAAAF CCCCCCCCCCCCHHH	45.38	23403867
1260	Phosphorylation	RAAAFMGTPQNQTHQ CCHHHCCCCCCCCCC	15.20	27422710
1265	Phosphorylation	MGTPQNQTHQQPHVL CCCCCCCCCCCCHHH	29.24	28555341
1291	Phosphorylation	LKDKAIKTPKRPGNS HHHHHCCCCCCCCCC	28.12	30576142
1298	Phosphorylation	TPKRPGNSTVTSSPP CCCCCCCCCCCCCCC	30.12	30266825
1299	Phosphorylation	PKRPGNSTVTSSPPV CCCCCCCCCCCCCCC	31.63	30266825
1301	Phosphorylation	RPGNSTVTSSPPVTP CCCCCCCCCCCCCCC	24.47	30266825
1302	Phosphorylation	PGNSTVTSSPPVTPK CCCCCCCCCCCCCCC	36.19	30266825
1303	Phosphorylation	GNSTVTSSPPVTPKK CCCCCCCCCCCCCCH	24.69	23401153
1306	Phosphorylation	TVTSSPPVTPKKLFT CCCCCCCCCCCHHCC	19.01	33259812
1307	Phosphorylation	VTSSPPVTPKKLFTS CCCCCCCCCCHHCCC	34.85	23401153
1313	Phosphorylation	VTPKKLFTSPLCDVS CCCCHHCCCCCCCCC	39.61	29255136
1314	Phosphorylation	TPKKLFTSPLCDVSK CCCHHCCCCCCCCCC	14.45	19664994
1320	Phosphorylation	TSPLCDVSKKSPFRK CCCCCCCCCCCCCCC	22.55	29396449
1323	Phosphorylation	LCDVSKKSPFRKSKI CCCCCCCCCCCCCCC	32.76	30576142
1328	Phosphorylation	KKSPFRKSKIECPSP CCCCCCCCCCCCCCC	34.31	30576142
1334	Phosphorylation	KSKIECPSPGELDQK CCCCCCCCCCCCCCC	58.14	19664994
1346	Phosphorylation	DQKEPQMSPSVAASL CCCCCCCCHHHHHHH	14.58	30576142
1348	Phosphorylation	KEPQMSPSVAASLSC CCCCCCHHHHHHHCC	19.65	30576142
1352	Phosphorylation	MSPSVAASLSCPVPS CCHHHHHHHCCCCCC	15.86	30576142
1354	Phosphorylation	PSVAASLSCPVPSTP HHHHHHHCCCCCCCC	17.55	30576142
1359	Phosphorylation	SLSCPVPSTPPELSQ HHCCCCCCCCCHHHC	54.50	25159151
1360	Phosphorylation	LSCPVPSTPPELSQR HCCCCCCCCCHHHCC	36.47	30576142
1365	Phosphorylation	PSTPPELSQRATLDT CCCCCHHHCCCCCCC	18.89	26074081
1369	Phosphorylation	PELSQRATLDTVPPP CHHHCCCCCCCCCCC	27.62	26074081
1372	Phosphorylation	SQRATLDTVPPPPPS HCCCCCCCCCCCCCC	37.72	-
1379	Phosphorylation	TVPPPPPSKVGKRCR CCCCCCCCHHCHHCC	45.83	28555341
1394	Phosphorylation	KTSDPRRSIVECQPD CCCCCCCCCEEECCC	32.06	26552605
1403	Phosphorylation	VECQPDASATPGVGT EEECCCCCCCCCCCC	39.80	30108239
1405	Phosphorylation	CQPDASATPGVGTAD ECCCCCCCCCCCCCC	20.34	30108239
1410	Phosphorylation	SATPGVGTADSPAAP CCCCCCCCCCCCCCC	25.53	23401153
1413	Phosphorylation	PGVGTADSPAAPTDS CCCCCCCCCCCCCCC	17.61	25159151
1418	Phosphorylation	ADSPAAPTDSRDDQK CCCCCCCCCCCCCCC	41.71	21955146
1420	Phosphorylation	SPAAPTDSRDDQKGL CCCCCCCCCCCCCCC	39.84	30108239
1428	Phosphorylation	RDDQKGLSLSPQSPP CCCCCCCCCCCCCCC	35.15	30266825
1430	Phosphorylation	DQKGLSLSPQSPPER CCCCCCCCCCCCCHH	19.95	30266825
1433	Phosphorylation	GLSLSPQSPPERRGY CCCCCCCCCCHHCCC	45.89	30266825
1440	Phosphorylation	SPPERRGYPGPGLRS CCCHHCCCCCCCCCC	11.82	26074081
1447	Phosphorylation	YPGPGLRSDWHASSP CCCCCCCCCCCCCCC	50.52	26074081
1452	Phosphorylation	LRSDWHASSPLLITS CCCCCCCCCCEEECC	21.43	28348404
1453	Phosphorylation	RSDWHASSPLLITSD CCCCCCCCCEEECCC	21.98	19276368
1458	Phosphorylation	ASSPLLITSDTEHVT CCCCEEECCCCCCEE	22.11	28122231
1459	Phosphorylation	SSPLLITSDTEHVTL CCCEEECCCCCCEEE	35.23	28122231
1461	Phosphorylation	PLLITSDTEHVTLLS CEEECCCCCCEEEEC	27.97	28122231
1465	Phosphorylation	TSDTEHVTLLSEAEH CCCCCCEEEECCHHH	24.72	28122231
1468	Phosphorylation	TEHVTLLSEAEHHGI CCCEEEECCHHHCCC	37.56	28122231
1484	Phosphorylation	DLKSNVLSVEEGEGL CCCCCEEEEECCCCC	24.17	21815630
1509	Phosphorylation	SHPGIPPSPPSCGPG CCCCCCCCCCCCCCC	44.05	-
1517	Phosphorylation	PPSCGPGSPLMPSRD CCCCCCCCCCCCCCC	20.28	-
1522	Phosphorylation	PGSPLMPSRDVHCTT CCCCCCCCCCEEECC	27.44	28555341
1553	Phosphorylation	SAWHSTDSASPQTYE HHCCCCCCCCCCEEE	30.63	28348404
1555	Phosphorylation	WHSTDSASPQTYEVE CCCCCCCCCCEEEEE	22.84	28348404
1558	Phosphorylation	TDSASPQTYEVELEM CCCCCCCEEEEEEEE	25.65	28348404
1559	Phosphorylation	DSASPQTYEVELEMQ CCCCCCEEEEEEEEE	16.84	28348404
1581	Phosphorylation	RIKKIDPSSSLEAEP EEEECCCCCCCCCCC	28.89	25159151
1582	Phosphorylation	IKKIDPSSSLEAEPL EEECCCCCCCCCCCC	44.31	25159151
1583	Phosphorylation	KKIDPSSSLEAEPLS EECCCCCCCCCCCCC	34.27	21815630
1590	Phosphorylation	SLEAEPLSKEESSLG CCCCCCCCHHHHCCC	49.05	21815630
1594	Phosphorylation	EPLSKEESSLGEESF CCCCHHHHCCCCCCC	31.77	20068231
1595	Phosphorylation	PLSKEESSLGEESFL CCCHHHHCCCCCCCH	43.61	20068231
1600	Phosphorylation	ESSLGEESFLPALSM HHCCCCCCCHHHHHC	27.99	27080861
1613	Phosphorylation	SMPRASRSLSKPEPT HCCCCCCCCCCCCCC	34.20	25159151
1615	Phosphorylation	PRASRSLSKPEPTYV CCCCCCCCCCCCCCC	47.62	26552605
1615	Ubiquitination	PRASRSLSKPEPTYV CCCCCCCCCCCCCCC	47.62	21963094
1616	Ubiquitination	RASRSLSKPEPTYVS CCCCCCCCCCCCCCC	59.71	21963094
1620	Phosphorylation	SLSKPEPTYVSPPCP CCCCCCCCCCCCCCC	34.59	25159151
1621	Phosphorylation	LSKPEPTYVSPPCPR CCCCCCCCCCCCCCC	15.05	26552605
1623	Phosphorylation	KPEPTYVSPPCPRLS CCCCCCCCCCCCCCC	16.83	25159151
1630	Phosphorylation	SPPCPRLSHSTPGKS CCCCCCCCCCCCCCC	19.37	27251275
1632	Phosphorylation	PCPRLSHSTPGKSRG CCCCCCCCCCCCCCC	32.68	25849741
1633	Phosphorylation	CPRLSHSTPGKSRGQ CCCCCCCCCCCCCCC	30.54	25849741
1668	Phosphorylation	QTDGVPWTPSPKHSG CCCCCCCCCCCCCCC	14.07	24719451
1670	Phosphorylation	DGVPWTPSPKHSGKT CCCCCCCCCCCCCCC	38.92	22210691
1674	Phosphorylation	WTPSPKHSGKTTPDI CCCCCCCCCCCCHHH	48.38	20873877
1677	Phosphorylation	SPKHSGKTTPDIIKD CCCCCCCCCHHHHHC	47.27	30576142
1678	Phosphorylation	PKHSGKTTPDIIKDW CCCCCCCCHHHHHCC	23.58	21815630
1714	Phosphorylation	ADLPGSLSLLESEGK CCCCCCHHHHHCCCC	32.38	21815630
1718	Phosphorylation	GSLSLLESEGKDHGL CCHHHHHCCCCCCCE	52.17	25159151
1728	Phosphorylation	KDHGLELSIHRTPIL CCCCEEEEEEECCCC	13.63	28555341
1732	Phosphorylation	LELSIHRTPILEDFE EEEEEEECCCCCCCE	10.66	25159151
1750	Phosphorylation	VCQLPDQSPPRNSMP EEECCCCCCCCCCCC	44.23	30278072
1755	Phosphorylation	DQSPPRNSMPKAEEA CCCCCCCCCCCHHHH	37.43	26074081
1764	Phosphorylation	PKAEEASSWGQFGLS CCHHHHCCHHHCCHH	42.12	25627689
1771	Phosphorylation	SWGQFGLSSRKRVLL CHHHCCHHHHCEEEH	28.60	25159151
1772	Phosphorylation	WGQFGLSSRKRVLLA HHHCCHHHHCEEEHH	47.03	25159151
1797	Phosphorylation	ICDLREDSEVSKSKE HHCHHCCCCCCCCCC	34.83	28555341
1802	Phosphorylation	EDSEVSKSKEGSPSW CCCCCCCCCCCCCCC	28.56	28348404
1806	Phosphorylation	VSKSKEGSPSWSAWQ CCCCCCCCCCCCCEE	19.49	28348404
1808	Phosphorylation	KSKEGSPSWSAWQLP CCCCCCCCCCCEECC	35.05	28348404
1810	Phosphorylation	KEGSPSWSAWQLPST CCCCCCCCCEECCCC	24.78	28348404
1816	Phosphorylation	WSAWQLPSTGDEEVF CCCEECCCCCCCEEE	54.32	28348404
1817	Phosphorylation	SAWQLPSTGDEEVFV CCEECCCCCCCEEEE	46.87	28348404
1825	Phosphorylation	GDEEVFVSGSTPPPS CCCEEEEECCCCCCC	18.63	28348404
1827	Phosphorylation	EEVFVSGSTPPPSCA CEEEEECCCCCCCHH	30.18	28348404
1828	Phosphorylation	EVFVSGSTPPPSCAV EEEEECCCCCCCHHH	43.25	28348404
1837	Phosphorylation	PPSCAVRSCLSASAL CCCHHHHHHCCHHHH	16.89	28464451
1840	Phosphorylation	CAVRSCLSASALQAL HHHHHHCCHHHHHHH	25.22	25850435
1842	Phosphorylation	VRSCLSASALQALTQ HHHHCCHHHHHHHHC	26.57	28464451
1848	Phosphorylation	ASALQALTQSPLLFQ HHHHHHHHCCCCHHC	29.98	25850435
1850	Phosphorylation	ALQALTQSPLLFQGK HHHHHHCCCCHHCCC	16.57	21815630
1876	Phosphorylation	EDVDVLPSTVEDSPF CCCCCCCCCCCCCCC	40.71	29978859
1877	Phosphorylation	DVDVLPSTVEDSPFS CCCCCCCCCCCCCCH	26.44	29978859
1881	Phosphorylation	LPSTVEDSPFSRAFS CCCCCCCCCCHHHHC	17.84	21815630
1884	Phosphorylation	TVEDSPFSRAFSRRR CCCCCCCHHHHCCCC	26.53	29396449
1894	Phosphorylation	FSRRRPISRTYTRKK HCCCCCCCCHHCHHH	22.66	24247654
1898	Phosphorylation	RPISRTYTRKKLMGT CCCCCHHCHHHHHCH	35.09	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
865	S	Phosphorylation	Kinase	CHEK1	O14757	GPS
969	T	Phosphorylation	Kinase	CDK2	P24941	PSP
969	T	Phosphorylation	Kinase	CDK2	-	PSP
1001	S	Phosphorylation	Kinase	CDK2	P24941	PSP
1001	S	Phosphorylation	Kinase	CDK2	-	PSP
1045	S	Phosphorylation	Kinase	CHEK1	O14757	GPS
1894	S	Phosphorylation	Kinase	CHEK1	O14757	GPS
1898	T	Phosphorylation	Kinase	CHEK1	O14757	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of TICRR_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TICRR_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TICRR_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1001; SER-1026; SER-1303AND THR-1307, AND MASS SPECTROMETRY.	19690332 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1080; SER-1303 ANDTHR-1307, AND MASS SPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-599; SER-1303; THR-1307AND SER-1413, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-441 AND THR-1134, ANDMASS SPECTROMETRY.	18220336 [Abstract]