| UniProt ID | TICN3_HUMAN | |
|---|---|---|
| UniProt AC | Q9BQ16 | |
| Protein Name | Testican-3 | |
| Gene Name | SPOCK3 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 436 | |
| Subcellular Localization | Secreted, extracellular space, extracellular matrix. | |
| Protein Description | May participate in diverse steps of neurogenesis. Inhibits the processing of pro-matrix metalloproteinase 2 (MMP-2) by MT1-MMP and MT3-MMP. May interfere with tumor invasion.. | |
| Protein Sequence | MLKVSAVLCVCAAAWCSQSLAAAAAVAAAGGRSDGGNFLDDKQWLTTISQYDKEVGQWNKFRDEVEDDYFRTWSPGKPFDQALDPAKDPCLKMKCSRHKVCIAQDSQTAVCISHRRLTHRMKEAGVDHRQWRGPILSTCKQCPVVYPSPVCGSDGHTYSFQCKLEYQACVLGKQISVKCEGHCPCPSDKPTSTSRNVKRACSDLEFREVANRLRDWFKALHESGSQNKKTKTLLRPERSRFDTSILPICKDSLGWMFNRLDTNYDLLLDQSELRSIYLDKNEQCTKAFFNSCDTYKDSLISNNEWCYCFQRQQDPPCQTELSNIQKRQGVKKLLGQYIPLCDEDGYYKPTQCHGSVGQCWCVDRYGNEVMGSRINGVADCAIDFEISGDFASGDFHEWTDDEDDEDDIMNDEDEIEDDDEDEGDDDDGGDDHDVYI | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 6 (in isoform 6) | Phosphorylation | - | 10.99 | 26552605 | |
| 9 (in isoform 6) | Phosphorylation | - | 1.58 | 26552605 | |
| 11 (in isoform 6) | Phosphorylation | - | 1.76 | 26552605 | |
| 13 (in isoform 6) | Phosphorylation | - | 9.07 | 26552605 | |
| 16 (in isoform 6) | Phosphorylation | - | 1.97 | - | |
| 21 (in isoform 4) | Phosphorylation | - | 10.57 | 27251275 | |
| 22 (in isoform 6) | Phosphorylation | - | 11.70 | - | |
| 24 (in isoform 6) | Phosphorylation | - | 9.57 | - | |
| 33 | Phosphorylation | VAAAGGRSDGGNFLD HHHHCCCCCCCCCCC | 43.83 | 18702456 | |
| 223 | Phosphorylation | WFKALHESGSQNKKT HHHHHHHHCCCCCCC | 32.75 | - | |
| 225 | Phosphorylation | KALHESGSQNKKTKT HHHHHHCCCCCCCCC | 39.60 | - | |
| 291 | Phosphorylation | CTKAFFNSCDTYKDS HHHHHHHCCCCHHHH | 14.28 | 30576142 | |
| 295 | Phosphorylation | FFNSCDTYKDSLISN HHHCCCCHHHHHHHC | 10.27 | 30576142 | |
| 337 | Phosphorylation | VKKLLGQYIPLCDED HHHHHHHHCCCCCCC | 11.60 | 25262027 | |
| 346 | Phosphorylation | PLCDEDGYYKPTQCH CCCCCCCCCCCCCCC | 22.19 | 25262027 | |
| 347 | Phosphorylation | LCDEDGYYKPTQCHG CCCCCCCCCCCCCCC | 18.93 | 25262027 | |
| 365 | Phosphorylation | QCWCVDRYGNEVMGS CEEEECCCCCEECCC | 21.60 | - | |
| 372 | Phosphorylation | YGNEVMGSRINGVAD CCCEECCCCCCCCCC | 16.34 | - | |
| 387 | O-linked_Glycosylation | CAIDFEISGDFASGD EEEEEEEECCCCCCC | 25.72 | - | |
| 392 | O-linked_Glycosylation | EISGDFASGDFHEWT EEECCCCCCCCCCCC | 38.60 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of TICN3_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of TICN3_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of TICN3_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| TICN2_HUMAN | SPOCK2 | physical | 12810672 | |
| MMP3_HUMAN | MMP3 | physical | 11751414 | |
| MMP14_HUMAN | MMP14 | physical | 11751414 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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