TIC62_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TIC62_ARATH
• UniProt AC: Q8H0U5
• Protein Name: Protein TIC 62, chloroplastic {ECO:0000303|PubMed:12426385}
• Gene Name: TIC62 {ECO:0000303|PubMed:12426385}
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 641
• Subcellular Localization: Plastid, chloroplast inner membrane ; Peripheral membrane protein . Plastid, chloroplast stroma . Plastid, chloroplast thylakoid . Shuttles between the membranes and the stroma, depending on the redox state of the plastidic NADP(+)/NADPH pool.
• Protein Description: Involved in protein precursor import into chloroplasts. Part of the redox regulon consisting of TIC32, TIC 55 and TIC62. [PubMed: 12426385 Acts as a membrane anchor of LFNR1 and LFNR2. Has a NADPH-dependent dehydrogenase activity, but only after preincubation with lipids (By similarity]
• Protein Sequence: MEGTCFLRGQPLTTIPSLPSRKGFLLQRWKTNRIVRFSGFKNHSVSGKSRSFDLSLRASGPIRASSVVTEASPTNLNSKEEDLVFVAGATGKVGSRTVRELLKLGFRVRAGVRSAQRAGSLVQSVKEMKLQNTDEGTQPVEKLEIVECDLEKKDSIQPALGNASVIICCIGASEKEISDITGPYRIDYLATKNLVDAATSAKVNNFILVTSLGTNKFGFPAAILNLFWGVLCWKRKAEEALIESGLNYAIVRPGGMERPTDAYKETHNLTLALDDTLFGGQVSNLQVAELLACMAKNPQLSFSKIVEVVAETTAPLTPIEKLLEKIPSKRPYVPPPKASVATKEVKPVPTKPVTQEPTAPKEDEAPPKEKNVKPRPLSPYASYEDLKPPTSPIPNSTTSVSPAKSKEVDATQVPVEANVVPVPDSTSNVPVVEVKQVEEKKERPLSPYARYENLKPPSSPSPTASSTRKSDSLSPGPTDSDTDKSSTVAKTVTETAVATSVTETSVATSVPETAVATSVTETAAPATSKMRPLSPYAIYADLKPPTSPTPASTGPKEAASVEDNSELPGGNNDVLKTVDGNLNTIPPSTPEAVPVVSSAIDTSLASGDNTAQPKPRPLSPYTMYADMKPPTSPLPSPVTNH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
59	Phosphorylation	FDLSLRASGPIRASS EEEEEEECCCEECEE	38.37	23776212
64	Acetylation	RASGPIRASSVVTEA EECCCEECEEEEEEC	13.58	22223895
65	Phosphorylation	ASGPIRASSVVTEAS ECCCEECEEEEEECC	17.51	23776212
66	Phosphorylation	SGPIRASSVVTEASP CCCEECEEEEEECCC	21.44	23776212
69	Phosphorylation	IRASSVVTEASPTNL EECEEEEEECCCCCC	24.55	23776212
72	Phosphorylation	SSVVTEASPTNLNSK EEEEEECCCCCCCCC	26.48	23776212
74	Phosphorylation	VVTEASPTNLNSKEE EEEECCCCCCCCCCC	50.25	23776212
78	Phosphorylation	ASPTNLNSKEEDLVF CCCCCCCCCCCCEEE	44.61	23776212
120	Phosphorylation	RSAQRAGSLVQSVKE HHHHHHHHHHHHHHH	25.12	25561503
317	Phosphorylation	AETTAPLTPIEKLLE HHCCCCCCHHHHHHH	22.59	30291188
470	Phosphorylation	TASSTRKSDSLSPGP CCCCCCCCCCCCCCC	29.19	19376835
472	Phosphorylation	SSTRKSDSLSPGPTD CCCCCCCCCCCCCCC	37.53	19376835
474	Phosphorylation	TRKSDSLSPGPTDSD CCCCCCCCCCCCCCC	31.59	19376835
478	Phosphorylation	DSLSPGPTDSDTDKS CCCCCCCCCCCCCCC	54.79	19376835
480	Phosphorylation	LSPGPTDSDTDKSST CCCCCCCCCCCCCCC	44.91	27545962
482	Phosphorylation	PGPTDSDTDKSSTVA CCCCCCCCCCCCCHH	49.64	19376835
485	Phosphorylation	TDSDTDKSSTVAKTV CCCCCCCCCCHHHHH	33.77	19376835
486	Phosphorylation	DSDTDKSSTVAKTVT CCCCCCCCCHHHHHH	32.42	19376835
487	Phosphorylation	SDTDKSSTVAKTVTE CCCCCCCCHHHHHHC	31.41	19376835

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TIC62_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TIC62_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TIC62_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
FNRL1_ARATH	FNR1	physical	20040542
FNRL2_ARATH	FNR2	physical	20040542

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.