THYG_HUMAN - dbPTM
THYG_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID THYG_HUMAN
UniProt AC P01266
Protein Name Thyroglobulin {ECO:0000305}
Gene Name TG {ECO:0000312|HGNC:HGNC:11764}
Organism Homo sapiens (Human).
Sequence Length 2768
Subcellular Localization Secreted.
Protein Description Precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3)..
Protein Sequence MALVLEIFTLLASICWVSANIFEYQVDAQPLRPCELQRETAFLKQADYVPQCAEDGSFQTVQCQNDGRSCWCVGANGSEVLGSRQPGRPVACLSFCQLQKQQILLSGYINSTDTSYLPQCQDSGDYAPVQCDVQQVQCWCVDAEGMEVYGTRQLGRPKRCPRSCEIRNRRLLHGVGDKSPPQCSAEGEFMPVQCKFVNTTDMMIFDLVHSYNRFPDAFVTFSSFQRRFPEVSGYCHCADSQGRELAETGLELLLDEIYDTIFAGLDLPSTFTETTLYRILQRRFLAVQSVISGRFRCPTKCEVERFTATSFGHPYVPSCRRNGDYQAVQCQTEGPCWCVDAQGKEMHGTRQQGEPPSCAEGQSCASERQQALSRLYFGTSGYFSQHDLFSSPEKRWASPRVARFATSCPPTIKELFVDSGLLRPMVEGQSQQFSVSENLLKEAIRAIFPSRGLARLALQFTTNPKRLQQNLFGGKFLVNVGQFNLSGALGTRGTFNFSQFFQQLGLASFLNGGRQEDLAKPLSVGLDSNSSTGTPEAAKKDGTMNKPTVGSFGFEINLQENQNALKFLASLLELPEFLLFLQHAISVPEDVARDLGDVMETVLSSQTCEQTPERLFVPSCTTEGSYEDVQCFSGECWCVNSWGKELPGSRVRGGQPRCPTDCEKQRARMQSLMGSQPAGSTLFVPACTSEGHFLPVQCFNSECYCVDAEGQAIPGTRSAIGKPKKCPTPCQLQSEQAFLRTVQALLSNSSMLPTLSDTYIPQCSTDGQWRQVQCNGPPEQVFELYQRWEAQNKGQDLTPAKLLVKIMSYREAASGNFSLFIQSLYEAGQQDVFPVLSQYPSLQDVPLAALEGKRPQPRENILLEPYLFWQILNGQLSQYPGSYSDFSTPLAHFDLRNCWCVDEAGQELEGMRSEPSKLPTCPGSCEEAKLRVLQFIRETEEIVSASNSSRFPLGESFLVAKGIRLRNEDLGLPPLFPPREAFAEQFLRGSDYAIRLAAQSTLSFYQRRRFSPDDSAGASALLRSGPYMPQCDAFGSWEPVQCHAGTGHCWCVDEKGGFIPGSLTARSLQIPQCPTTCEKSRTSGLLSSWKQARSQENPSPKDLFVPACLETGEYARLQASGAGTWCVDPASGEELRPGSSSSAQCPSLCNVLKSGVLSRRVSPGYVPACRAEDGGFSPVQCDQAQGSCWCVMDSGEEVPGTRVTGGQPACESPRCPLPFNASEVVGGTILCETISGPTGSAMQQCQLLCRQGSWSVFPPGPLICSLESGRWESQLPQPRACQRPQLWQTIQTQGHFQLQLPPGKMCSADYADLLQTFQVFILDELTARGFCQIQVKTFGTLVSIPVCNNSSVQVGCLTRERLGVNVTWKSRLEDIPVASLPDLHDIERALVGKDLLGRFTDLIQSGSFQLHLDSKTFPAETIRFLQGDHFGTSPRTWFGCSEGFYQVLTSEASQDGLGCVKCPEGSYSQDEECIPCPVGFYQEQAGSLACVPCPVGRTTISAGAFSQTHCVTDCQRNEAGLQCDQNGQYRASQKDRGSGKAFCVDGEGRRLPWWETEAPLEDSQCLMMQKFEKVPESKVIFDANAPVAVRSKVPDSEFPVMQCLTDCTEDEACSFFTVSTTEPEISCDFYAWTSDNVACMTSDQKRDALGNSKATSFGSLRCQVKVRSHGQDSPAVYLKKGQGSTTTLQKRFEPTGFQNMLSGLYNPIVFSASGANLTDAHLFCLLACDRDLCCDGFVLTQVQGGAIICGLLSSPSVLLCNVKDWMDPSEAWANATCPGVTYDQESHQVILRLGDQEFIKSLTPLEGTQDTFTNFQQVYLWKDSDMGSRPESMGCRKDTVPRPASPTEAGLTTELFSPVDLNQVIVNGNQSLSSQKHWLFKHLFSAQQANLWCLSRCVQEHSFCQLAEITESASLYFTCTLYPEAQVCDDIMESNAQGCRLILPQMPKALFRKKVILEDKVKNFYTRLPFQKLMGISIRNKVPMSEKSISNGFFECERRCDADPCCTGFGFLNVSQLKGGEVTCLTLNSLGIQMCSEENGGAWRILDCGSPDIEVHTYPFGWYQKPIAQNNAPSFCPLVVLPSLTEKVSLDSWQSLALSSVVVDPSIRHFDVAHVSTAATSNFSAVRDLCLSECSQHEACLITTLQTQPGAVRCMFYADTQSCTHSLQGQNCRLLLREEATHIYRKPGISLLSYEASVPSVPISTHGRLLGRSQAIQVGTSWKQVDQFLGVPYAAPPLAERRFQAPEPLNWTGSWDASKPRASCWQPGTRTSTSPGVSEDCLYLNVFIPQNVAPNASVLVFFHNTMDREESEGWPAIDGSFLAAVGNLIVVTASYRVGVFGFLSSGSGEVSGNWGLLDQVAALTWVQTHIRGFGGDPRRVSLAADRGGADVASIHLLTARATNSQLFRRAVLMGGSALSPAAVISHERAQQQAIALAKEVSCPMSSSQEVVSCLRQKPANVLNDAQTKLLAVSGPFHYWGPVIDGHFLREPPARALKRSLWVEVDLLIGSSQDDGLINRAKAVKQFEESRGRTSSKTAFYQALQNSLGGEDSDARVEAAATWYYSLEHSTDDYASFSRALENATRDYFIICPIIDMASAWAKRARGNVFMYHAPENYGHGSLELLADVQFALGLPFYPAYEGQFSLEEKSLSLKIMQYFSHFIRSGNPNYPYEFSRKVPTFATPWPDFVPRAGGENYKEFSELLPNRQGLKKADCSFWSKYISSLKTSADGAKGGQSAESEEEELTAGSGLREDLLSLQEPGSKTYSK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
24IodinationVSANIFEYQVDAQPL
HHCCCEEEECCCCCC		11.772760035
24OtherVSANIFEYQVDAQPL
HHCCCEEEECCCCCC		11.772760035
24SulfationVSANIFEYQVDAQPL
HHCCCEEEECCCCCC		11.77-
24SulfationVSANIFEYQVDAQPL
HHCCCEEEECCCCCC		11.77-
76N-linked_GlycosylationSCWCVGANGSEVLGS
EEEEEECCCCEEECC		48.9032025030
76N-linked_GlycosylationSCWCVGANGSEVLGS
EEEEEECCCCEEECC		48.9032025030
108IodinationQQILLSGYINSTDTS
CHHHHHCCCCCCCCC		8.1132025030
110N-linked_GlycosylationILLSGYINSTDTSYL
HHHHCCCCCCCCCCC		30.308530385
110N-linked_GlycosylationILLSGYINSTDTSYL
HHHHCCCCCCCCCCC		30.3032025030
149IodinationDAEGMEVYGTRQLGR
CCCCCEEEEECCCCC		10.242760035
198N-linked_GlycosylationPVQCKFVNTTDMMIF
CEECEECCCCCCHHH		40.1532025030
198N-linked_GlycosylationPVQCKFVNTTDMMIF
CEECEECCCCCCHHH		40.1532025030
199PhosphorylationVQCKFVNTTDMMIFD
EECEECCCCCCHHHH		20.9022210691
200PhosphorylationQCKFVNTTDMMIFDL
ECEECCCCCCHHHHH		19.3822210691
234IodinationRFPEVSGYCHCADSQ
HCCCCCCEEEECCHH		3.2932025030
234PhosphorylationRFPEVSGYCHCADSQ
HCCCCCCEEEECCHH		3.29-
240PhosphorylationGYCHCADSQGRELAE
CEEEECCHHCHHHHH		18.93-
258IodinationELLLDEIYDTIFAGL
HHHHHHHHHHHHCCC		12.652760035
376PhosphorylationQQALSRLYFGTSGYF
HHHHHHHHHCCCCCC		10.00-
484N-linked_GlycosylationLVNVGQFNLSGALGT
EEEEEEEECCCCCCC		25.9632025030
484N-linked_GlycosylationLVNVGQFNLSGALGT
EEEEEEEECCCCCCC		25.9632025030
529N-linked_GlycosylationLSVGLDSNSSTGTPE
CCCCCCCCCCCCCHH		39.388615697
529N-linked_GlycosylationLSVGLDSNSSTGTPE
CCCCCCCCCCCCCHH		39.388615697
704IodinationQCFNSECYCVDAEGQ
EEECCEEEEECCCCC		7.462760035
704OtherQCFNSECYCVDAEGQ
EEECCEEEEECCCCC		7.462760035
748N-linked_GlycosylationTVQALLSNSSMLPTL
HHHHHHHCCCCCCCC		37.778615697
748N-linked_GlycosylationTVQALLSNSSMLPTL
HHHHHHHCCCCCCCC		37.778615697
785IodinationPEQVFELYQRWEAQN
HHHHHHHHHHHHHHH		6.712760035
816N-linked_GlycosylationYREAASGNFSLFIQS
HHHHHCCCHHHHHHH		22.349287346
816N-linked_GlycosylationYREAASGNFSLFIQS
HHHHHCCCHHHHHHH		22.349287346
866IodinationENILLEPYLFWQILN
CCCCCCHHHHHHHHC		12.732760035
883IodinationLSQYPGSYSDFSTPL
HHCCCCCCCCCCCCC		20.412760035
939PhosphorylationVLQFIRETEEIVSAS
HHHHHHHHHHHHHCC		29.12-
947N-linked_GlycosylationEEIVSASNSSRFPLG
HHHHHCCCCCCCCCC		43.669287346
947N-linked_GlycosylationEEIVSASNSSRFPLG
HHHHHCCCCCCCCCC		43.669287346
992IodinationQFLRGSDYAIRLAAQ
HHHCCCHHHHHHHHH		12.962760035
1005PhosphorylationAQSTLSFYQRRRFSP
HHHHHHHHHHCCCCC		9.57-
1011PhosphorylationFYQRRRFSPDDSAGA
HHHHCCCCCCCCCHH		26.1322210691
1019PhosphorylationPDDSAGASALLRSGP
CCCCCHHHHHHHCCC		20.6624719451
1082PhosphorylationTTCEKSRTSGLLSSW
CCCCHHCCCCCHHHH		33.9526437602
1083PhosphorylationTCEKSRTSGLLSSWK
CCCHHCCCCCHHHHH		26.7426437602
1087PhosphorylationSRTSGLLSSWKQARS
HCCCCCHHHHHHHHC		38.9126437602
1088PhosphorylationRTSGLLSSWKQARSQ
CCCCCHHHHHHHHCC		37.9626437602
1154PhosphorylationSLCNVLKSGVLSRRV
HHHHHHHHCCCCCCC		29.9430576142
1158PhosphorylationVLKSGVLSRRVSPGY
HHHHCCCCCCCCCCC		18.6824719451
1165PhosphorylationSRRVSPGYVPACRAE
CCCCCCCCCCCEECC		13.47-
1220N-linked_GlycosylationPRCPLPFNASEVVGG
CCCCCCCCHHHEECC		40.3932025030
1220N-linked_GlycosylationPRCPLPFNASEVVGG
CCCCCCCCHHHEECC		40.3932025030
1310ThyroxineGKMCSADYADLLQTF
CCCCCCCHHHHHHHH		11.17-
1310IodinationGKMCSADYADLLQTF
CCCCCCCHHHHHHHH		11.172760035
1310OtherGKMCSADYADLLQTF
CCCCCCCHHHHHHHH		11.172760035
1348N-linked_GlycosylationLVSIPVCNNSSVQVG
EEEEEECCCCCEEEE		52.218615697
1348N-linked_GlycosylationLVSIPVCNNSSVQVG
EEEEEECCCCCEEEE		52.218615697
1349N-linked_GlycosylationVSIPVCNNSSVQVGC
EEEEECCCCCEEEEE		30.4532025030
1365N-linked_GlycosylationTRERLGVNVTWKSRL
EHHHCCCCEEECHHC		24.5732025030
1365N-linked_GlycosylationTRERLGVNVTWKSRL
EHHHCCCCEEECHHC		24.5732025030
1421PhosphorylationSKTFPAETIRFLQGD
CCCCCHHHHHHHCCC		21.40-
1449PhosphorylationEGFYQVLTSEASQDG
CCCHHHHCCCCCCCC		26.1827251275
1450PhosphorylationGFYQVLTSEASQDGL
CCHHHHCCCCCCCCC		27.3127251275
1453PhosphorylationQVLTSEASQDGLGCV
HHHCCCCCCCCCCEE		25.4227251275
1467IodinationVKCPEGSYSQDEECI
EECCCCCCCCCCCCE		22.622760035
1498 (in isoform 2)Phosphorylation-23.6617929957
1508 (in isoform 2)Phosphorylation-18.9517929957
1529PhosphorylationQCDQNGQYRASQKDR
CCCCCCCEECCCCCC		15.00-
1577PhosphorylationKFEKVPESKVIFDAN
CCCCCCCCCEEEECC		26.59-
1591PhosphorylationNAPVAVRSKVPDSEF
CCCEEEECCCCCCCC		31.26-
1652PhosphorylationKRDALGNSKATSFGS
HHHHCCCCCCCCCCC		23.1318452278
1716N-linked_GlycosylationVFSASGANLTDAHLF
EEECCCCCCCHHHHH		47.1832025030
1716N-linked_GlycosylationVFSASGANLTDAHLF
EEECCCCCCCHHHHH		47.1832025030
1774N-linked_GlycosylationDPSEAWANATCPGVT
CHHHHHHCCCCCCCC		25.6932025030
1774N-linked_GlycosylationDPSEAWANATCPGVT
CHHHHHHCCCCCCCC		25.6932025030
1839PhosphorylationSMGCRKDTVPRPASP
HHCCCCCCCCCCCCC		35.1324905233
1869N-linked_GlycosylationNQVIVNGNQSLSSQK
CCEEECCCCCCHHCH		24.0632025030
2013N-linked_GlycosylationCTGFGFLNVSQLKGG
CCCEEEEEHHHCCCC		29.1832025030
2013N-linked_GlycosylationCTGFGFLNVSQLKGG
CCCEEEEEHHHCCCC		29.1832025030
2122N-linked_GlycosylationVSTAATSNFSAVRDL
CCCCCCCCCHHHHHH		30.4532025030
2184IodinationREEATHIYRKPGISL
HHHHHHHHCCCCEEE		12.652760035
2184PhosphorylationREEATHIYRKPGISL
HHHHHHHHCCCCEEE		12.65-
2250N-linked_GlycosylationFQAPEPLNWTGSWDA
CCCCCCCCCCCCCCC		45.0032025030
2250N-linked_GlycosylationFQAPEPLNWTGSWDA
CCCCCCCCCCCCCCC		45.0032025030
2295N-linked_GlycosylationIPQNVAPNASVLVFF
CCCCCCCCCEEEEEE		34.8032025030
2295N-linked_GlycosylationIPQNVAPNASVLVFF
CCCCCCCCCEEEEEE		34.8032025030
2467PhosphorylationNVLNDAQTKLLAVSG
HHCCHHHHHHHEECC		25.94-
2510PhosphorylationEVDLLIGSSQDDGLI
EEEEECCCCCCCCHH		20.1723828894
2540IodinationTSSKTAFYQALQNSL
CCHHHHHHHHHHHHH		7.1632025030
2573ThyroxineLEHSTDDYASFSRAL
CCCCCCCHHHHHHHH		13.62-
2573IodinationLEHSTDDYASFSRAL
CCCCCCCHHHHHHHH		13.622760035
2573OtherLEHSTDDYASFSRAL
CCCCCCCHHHHHHHH		13.622760035
2575PhosphorylationHSTDDYASFSRALEN
CCCCCHHHHHHHHHH		19.9524719451
2582N-linked_GlycosylationSFSRALENATRDYFI
HHHHHHHHHCCCEEE		47.6832025030
2582N-linked_GlycosylationSFSRALENATRDYFI
HHHHHHHHHCCCEEE		47.6832025030
2587ThyroxineLENATRDYFIICPII
HHHHCCCEEEEEHHH		8.06-
2587IodinationLENATRDYFIICPII
HHHHCCCEEEEEHHH		8.062760035
2617IodinationMYHAPENYGHGSLEL
EEECCCCCCCCCHHH		14.612760035
2650PhosphorylationQFSLEEKSLSLKIMQ
CCCCCHHHHHHHHHH		26.8624719451
2652PhosphorylationSLEEKSLSLKIMQYF
CCCHHHHHHHHHHHH		34.4124719451
2658PhosphorylationLSLKIMQYFSHFIRS
HHHHHHHHHHHHHHC		6.9425884760
2670PhosphorylationIRSGNPNYPYEFSRK
HHCCCCCCCCCCCCC		14.4025884760
2697IodinationPRAGGENYKEFSELL
CCCCCCCHHHHHHHC		13.952760035
2721PhosphorylationDCSFWSKYISSLKTS
CHHHHHHHHHHHCCC		10.6622817900
2723PhosphorylationSFWSKYISSLKTSAD
HHHHHHHHHHCCCCC		26.9124719451
2724PhosphorylationFWSKYISSLKTSADG
HHHHHHHHHCCCCCC		25.0729083192
2728PhosphorylationYISSLKTSADGAKGG
HHHHHCCCCCCCCCC		23.8319664994
2737PhosphorylationDGAKGGQSAESEEEE
CCCCCCCCCCCHHHH		36.9627251275
2740PhosphorylationKGGQSAESEEEELTA
CCCCCCCCHHHHHHC		50.4527251275
2749O-linked_GlycosylationEEELTAGSGLREDLL
HHHHHCCCCHHHHHH		31.9916679516
2766TriiodothyronineQEPGSKTYSK-----
CCCCCCCCCC-----		20.42-
2766IodinationQEPGSKTYSK-----
CCCCCCCCCC-----		20.422760035
2766OtherQEPGSKTYSK-----
CCCCCCCCCC-----		20.422760035
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of THYG_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of THYG_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of THYG_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
THYG_HUMANTGphysical
11294872
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
274700Thyroid dyshormonogenesis 3 (TDH3)
608175Autoimmune thyroid disease 3 (AITD3)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of THYG_HUMAN

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Related Literatures of Post-Translational Modification
N-linked Glycosylation
ReferencePubMed
"Glycosylation in human thyroglobulin: location of the N-linkedoligosaccharide units and comparison with bovine thyroglobulin.";
Yang S.X., Pollock H.G., Rawitch A.B.;
Arch. Biochem. Biophys. 327:61-70(1996).
Cited for: PARTIAL PROTEIN SEQUENCE, GLYCOSYLATION AT ASN-76; ASN-198; ASN-484;ASN-529; ASN-748; ASN-816; ASN-947; ASN-1220; ASN-1348; ASN-1349;ASN-1365; ASN-1716; ASN-1774; ASN-2013; ASN-2250; ASN-2295 ANDASN-2582, AND ABSENCE OF GLYCOSYLATION AT ASN-110; ASN-496; ASN-1869AND ASN-2122.
O-linked Glycosylation
ReferencePubMed
"A single chondroitin 6-sulfate oligosaccharide unit at Ser-2730 ofhuman thyroglobulin enhances hormone formation and limits proteolyticaccessibility at the carboxyl terminus. Potential insights intothyroid homeostasis and autoimmunity.";
Conte M., Arcaro A., D'Angelo D., Gnata A., Mamone G., Ferranti P.,Formisano S., Gentile F.;
J. Biol. Chem. 281:22200-22211(2006).
Cited for: GLYCOSYLATION AT SER-2749.

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