dbPTM

TGON3_RAT - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TGON3_RAT
UniProt AC	P19814
Protein Name	Trans-Golgi network integral membrane protein TGN38
Gene Name	Ttgn1
Organism	Rattus norvegicus (Rat).
Sequence Length	357
Subcellular Localization	Golgi apparatus, trans-Golgi network membrane Single-pass membrane protein .
Protein Description
Protein Sequence	MQFLVALLLLSVAVARALPSASKPNNTSSENNPPIQPSTPLPPGVDISQQVKTNRPTDQRLESDKEGQDKTVARTSASVSSGVESATNLNLDDSKKHPETADAKLKETLQQLLPVDPKQEKSGQKFTKDSGSPTGGDSDNTTGGDSNKTTGVDSDKTSGGDSNKPTGSDNDKPTGGDSNKPTSKVPSNTETPKIDKVQLTEKGQKPTLISKTESGEKLAGDSDFSLKPEKGDKSSEPTEDVETKEIEEGDTEPEEGSPLEEENEKVLGPSSSENQEGTLTDSMKDEKDDHYKDNSGNTSAESSHFFAYLVTAAVLVAVLYIAYHNKRKIIAFALEGKRSKVTRRPKASDYQRLNLKL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
25	N-linked_Glycosylation	LPSASKPNNTSSENN CCCCCCCCCCCCCCC	69.05	-
26	N-linked_Glycosylation	PSASKPNNTSSENNP CCCCCCCCCCCCCCC	50.28	-
74	Methylation	GQDKTVARTSASVSS CCCCCHHHCCCCHHH	25.52	15047867
74	Dimethylation	GQDKTVARTSASVSS CCCCCHHHCCCCHHH	25.52	-
104	Acetylation	HPETADAKLKETLQQ CHHHHHHHHHHHHHH	61.72	22902405
127	Phosphorylation	EKSGQKFTKDSGSPT CCCCCCCCCCCCCCC	40.76	28689409
130	Phosphorylation	GQKFTKDSGSPTGGD CCCCCCCCCCCCCCC	42.60	28689409
134	Phosphorylation	TKDSGSPTGGDSDNT CCCCCCCCCCCCCCC	56.33	28689409
138	Phosphorylation	GSPTGGDSDNTTGGD CCCCCCCCCCCCCCC	35.71	22108457
140	N-linked_Glycosylation	PTGGDSDNTTGGDSN CCCCCCCCCCCCCCC	43.42	-
141	Phosphorylation	TGGDSDNTTGGDSNK CCCCCCCCCCCCCCC	31.63	28432305
146	Phosphorylation	DNTTGGDSNKTTGVD CCCCCCCCCCCCCCC	43.43	28432305
147	N-linked_Glycosylation	NTTGGDSNKTTGVDS CCCCCCCCCCCCCCC	50.89	-
207	Phosphorylation	TEKGQKPTLISKTES CCCCCCCCEEEECCC	43.70	22673903
210	Phosphorylation	GQKPTLISKTESGEK CCCCCEEEECCCCCC	36.32	22673903
212	Phosphorylation	KPTLISKTESGEKLA CCCEEEECCCCCCCC	28.70	26437020
214	Phosphorylation	TLISKTESGEKLAGD CEEEECCCCCCCCCC	58.44	26437020
217	Acetylation	SKTESGEKLAGDSDF EECCCCCCCCCCCCC	47.35	22902405
222	Phosphorylation	GEKLAGDSDFSLKPE CCCCCCCCCCCCCCC	39.37	25575281
225	Phosphorylation	LAGDSDFSLKPEKGD CCCCCCCCCCCCCCC	40.24	25575281
227	Acetylation	GDSDFSLKPEKGDKS CCCCCCCCCCCCCCC	50.35	22902405
234	Phosphorylation	KPEKGDKSSEPTEDV CCCCCCCCCCCCCCC	44.68	29779826
235	Phosphorylation	PEKGDKSSEPTEDVE CCCCCCCCCCCCCCC	54.02	22108457
238	Phosphorylation	GDKSSEPTEDVETKE CCCCCCCCCCCCCEE	40.54	28432305
243	Phosphorylation	EPTEDVETKEIEEGD CCCCCCCCEECCCCC	33.55	22817900
251	Phosphorylation	KEIEEGDTEPEEGSP EECCCCCCCCCCCCC	65.38	22817900
257	Phosphorylation	DTEPEEGSPLEEENE CCCCCCCCCCHHHCC	29.59	23984901
270	Phosphorylation	NEKVLGPSSSENQEG CCCCCCCCCCCCCCC	44.70	27097102
271	Phosphorylation	EKVLGPSSSENQEGT CCCCCCCCCCCCCCC	44.82	10514494
272	Phosphorylation	KVLGPSSSENQEGTL CCCCCCCCCCCCCCC	44.92	27097102
278	Phosphorylation	SSENQEGTLTDSMKD CCCCCCCCCCCCCCC	26.23	23984901
280	Phosphorylation	ENQEGTLTDSMKDEK CCCCCCCCCCCCCCC	26.35	23984901
282	Phosphorylation	QEGTLTDSMKDEKDD CCCCCCCCCCCCCCC	23.61	23984901
291	Phosphorylation	KDEKDDHYKDNSGNT CCCCCCCCCCCCCCC	27.34	28689409

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of TGON3_RAT !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of TGON3_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TGON3_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
NEB1_RAT	Ppp1r9a	physical	10514494

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TGON3_RAT

Related Literatures of Post-Translational Modification

Methylation
Reference	PubMed
"Organellar proteomics reveals Golgi arginine dimethylation."; Wu C.C., MacCoss M.J., Mardones G., Finnigan C., Mogelsvang S.,Yates J.R. III, Howell K.E.; Mol. Biol. Cell 15:2907-2919(2004). Cited for: METHYLATION AT ARG-74, AND MASS SPECTROMETRY.	15047867 [Abstract]