NEB1_RAT - dbPTM
NEB1_RAT - PTM Information in dbPTM
Basic Information of Protein
UniProt ID NEB1_RAT
UniProt AC O35867
Protein Name Neurabin-1
Gene Name Ppp1r9a
Organism Rattus norvegicus (Rat).
Sequence Length 1095
Subcellular Localization Cytoplasm, cytoskeleton. Cell junction, synapse, synaptosome.
Protein Description Binds to actin filaments (F-actin) and shows cross-linking activity. Binds along the sides of the F-actin. May be involved in neurite formation. Inhibits protein phosphatase 1-alpha activity. May play an important role in linking the actin cytoskeleton to the plasma membrane at the synaptic junction..
Protein Sequence MLKAESSGERTTLRSASPHRNAYRTEFQALKSTFDKPKPDGEQKTKEGEGSQQSRGRKYGSNVNRIKNLFMQMGMEPNENAAIIAKTRGKGRPSSPQKRMKPKEFVEKTDGSVVKLESSVSERISRFDTMHDGPSYAKFTETRKMFERSGHESGQNNRHSPKKEKAGEAEPQDEWGGSKSNRGSSDSLDSLSPRTEAVSPTVSQLSAVFENSESPGAITPGKAENSNYSVTGHYPLNLPSVTVTNLDTFGRLKDSNSRPSSNKQATDTEEPEKSEAVPVPEVAQKGTSLASLPSEERQLSTEAEDVTAQPDTPDSTDKDSPGEPSAESQAMPKSNTLSRPKEPLEDAEANVVGSEAEQPQRRDLTGGGDLTSPDASASSCGKEVPEDSNSFEGSHVYMHSDYNVYRVRSRYNSDWGETGTEQDEGDDSDENNYYQPDMEYSEIVGLPQEEEIPANRKIKFSCAPIKVFNTYSNEDYDRRNDDVDPVAASAEYELEKRVEKLELFPVELEKDEDGLGISIIGMGVGADAGLEKLGIFVKTVTEGGAAQRDGRIQVNDQIVEVDGISLVGVTQNFAATVLRNTKGNVRFVIGREKPGQVSEVAQLISQTLEQERRQRELLERHYAQYDADDDETGEYATDEEEDEVGPILPGGDMAIEVFELPENEDMFSPSDLDTSKLSHKFKELQIKHAVTEAEIQKLKTKLQAAENEKVRWELEKNQLQQNIEENKERMVKLESYWIEAQTLCHTVNEHLKETQSQYQALEKKYNKAKKLIKDFQQKELDFIRRQEVERKKLEEVEKAHLVEVQGLQVRIRDLEAEVFRLLKQNGTQVNNNNNIFERRPSPGEVSKGDTMENVEVKQTSCQDGLSQDLNEAVPETERLDSKALKTRAQLSVKNRRQRPTRTRLYDSVSSTDGEDSLERKNFTFNDDFSPSSTSSADLSGLGAEPKTPGLSQSLALSSDESLDMIDDEILDDGQSPKHTQSQSRAVHEWSVQQVSHWLVGLSLDQYVSEFSAQNISGEQLLQLDGNKLKALGMTSSQDRALVKKKLKEMKMSLEKARKAQEKMEKQREKLRRKEQEQMQRKSKKSEKMTSTTEQP
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
17PhosphorylationRTTLRSASPHRNAYR
CCCCCCCCCCCCHHH		23.6125403869
94PhosphorylationTRGKGRPSSPQKRMK
CCCCCCCCCCCCCCC		53.9725403869
95PhosphorylationRGKGRPSSPQKRMKP
CCCCCCCCCCCCCCC		33.7527115346
160PhosphorylationSGQNNRHSPKKEKAG
CCCCCCCCCCHHCCC		34.8725403869
180PhosphorylationDEWGGSKSNRGSSDS
CCCCCCCCCCCCCCC		33.1927097102
184PhosphorylationGSKSNRGSSDSLDSL
CCCCCCCCCCCHHHC		27.9528432305
185PhosphorylationSKSNRGSSDSLDSLS
CCCCCCCCCCHHHCC		33.7628432305
187PhosphorylationSNRGSSDSLDSLSPR
CCCCCCCCHHHCCCC		35.7027097102
190PhosphorylationGSSDSLDSLSPRTEA
CCCCCHHHCCCCCHH		35.7227097102
192PhosphorylationSDSLDSLSPRTEAVS
CCCHHHCCCCCHHCC		19.1127097102
195PhosphorylationLDSLSPRTEAVSPTV
HHHCCCCCHHCCCCH		31.5127097102
199PhosphorylationSPRTEAVSPTVSQLS
CCCCHHCCCCHHHHH		23.1527097102
201PhosphorylationRTEAVSPTVSQLSAV
CCHHCCCCHHHHHHH		25.8627097102
203PhosphorylationEAVSPTVSQLSAVFE
HHCCCCHHHHHHHHC		28.0728432305
206PhosphorylationSPTVSQLSAVFENSE
CCCHHHHHHHHCCCC		18.1028432305
212PhosphorylationLSAVFENSESPGAIT
HHHHHCCCCCCCCCC		32.0527097102
214PhosphorylationAVFENSESPGAITPG
HHHCCCCCCCCCCCC		28.5827097102
291PhosphorylationQKGTSLASLPSEERQ
HCCCCHHCCCHHHHH		46.2128432305
294PhosphorylationTSLASLPSEERQLST
CCHHCCCHHHHHCCC		58.3328432305
300PhosphorylationPSEERQLSTEAEDVT
CHHHHHCCCCCHHCC		18.8327097102
301PhosphorylationSEERQLSTEAEDVTA
HHHHHCCCCCHHCCC		48.0527097102
307PhosphorylationSTEAEDVTAQPDTPD
CCCCHHCCCCCCCCC		31.7127097102
312PhosphorylationDVTAQPDTPDSTDKD
HCCCCCCCCCCCCCC		35.3627097102
315PhosphorylationAQPDTPDSTDKDSPG
CCCCCCCCCCCCCCC		39.4422673903
316PhosphorylationQPDTPDSTDKDSPGE
CCCCCCCCCCCCCCC		55.2222673903
328PhosphorylationPGEPSAESQAMPKSN
CCCCCHHHHCCCCCC		23.9726022182
338PhosphorylationMPKSNTLSRPKEPLE
CCCCCCCCCCCCCHH		44.49-
365PhosphorylationQPQRRDLTGGGDLTS
CCCCCCCCCCCCCCC		37.7628551015
371PhosphorylationLTGGGDLTSPDASAS
CCCCCCCCCCCCCHH		42.8427097102
372PhosphorylationTGGGDLTSPDASASS
CCCCCCCCCCCCHHH		28.2530411139
376PhosphorylationDLTSPDASASSCGKE
CCCCCCCCHHHCCCC		35.7428432305
418PhosphorylationYNSDWGETGTEQDEG
CCCCCCCCCCCCCCC		45.5322673903
420PhosphorylationSDWGETGTEQDEGDD
CCCCCCCCCCCCCCC		37.5822673903
428PhosphorylationEQDEGDDSDENNYYQ
CCCCCCCCCCCCCCC		52.1122673903
433PhosphorylationDDSDENNYYQPDMEY
CCCCCCCCCCCCCCH		18.3022673903
434PhosphorylationDSDENNYYQPDMEYS
CCCCCCCCCCCCCHH		18.7222673903
440PhosphorylationYYQPDMEYSEIVGLP
CCCCCCCHHHHCCCC		12.6422673903
441PhosphorylationYQPDMEYSEIVGLPQ
CCCCCCHHHHCCCCC		13.9322673903
461PhosphorylationANRKIKFSCAPIKVF
CCCCCEEEECEEEEE		12.3612052877
841PhosphorylationNIFERRPSPGEVSKG
CCCCCCCCCCCCCCC		43.6630240740
850PhosphorylationGEVSKGDTMENVEVK
CCCCCCCCCCCEEEE		34.7428432305
866PhosphorylationTSCQDGLSQDLNEAV
EECCCCCCCHHHHHC		27.46-
891PhosphorylationLKTRAQLSVKNRRQR
HHHHHHHHHCCCCCC		20.9722108457
905PhosphorylationRPTRTRLYDSVSSTD
CCCCCCCCCCCCCCC		11.6828432305
907PhosphorylationTRTRLYDSVSSTDGE
CCCCCCCCCCCCCCC		15.4428432305
909PhosphorylationTRLYDSVSSTDGEDS
CCCCCCCCCCCCCCC		31.3228432305
910PhosphorylationRLYDSVSSTDGEDSL
CCCCCCCCCCCCCCH		28.5028432305
911PhosphorylationLYDSVSSTDGEDSLE
CCCCCCCCCCCCCHH		40.2828432305
916PhosphorylationSSTDGEDSLERKNFT
CCCCCCCCHHHCCEE		28.0327097102
923PhosphorylationSLERKNFTFNDDFSP
CHHHCCEECCCCCCC		30.8128551015
929PhosphorylationFTFNDDFSPSSTSSA
EECCCCCCCCCCCCC		30.7628551015
931PhosphorylationFNDDFSPSSTSSADL
CCCCCCCCCCCCCCC		45.0828551015
932PhosphorylationNDDFSPSSTSSADLS
CCCCCCCCCCCCCCC		35.3728551015
933PhosphorylationDDFSPSSTSSADLSG
CCCCCCCCCCCCCCC		30.9128551015
934PhosphorylationDFSPSSTSSADLSGL
CCCCCCCCCCCCCCC		26.0228551015
935PhosphorylationFSPSSTSSADLSGLG
CCCCCCCCCCCCCCC		26.3728551015
939PhosphorylationSTSSADLSGLGAEPK
CCCCCCCCCCCCCCC		32.3028551015
947PhosphorylationGLGAEPKTPGLSQSL
CCCCCCCCCCCCHHH		33.0516641100
951PhosphorylationEPKTPGLSQSLALSS
CCCCCCCCHHHCCCC		24.5216641100
953PhosphorylationKTPGLSQSLALSSDE
CCCCCCHHHCCCCCC		16.5416641100
957PhosphorylationLSQSLALSSDESLDM
CCHHHCCCCCCCCCC		30.0928551015
958PhosphorylationSQSLALSSDESLDMI
CHHHCCCCCCCCCCC		46.3728551015
961PhosphorylationLALSSDESLDMIDDE
HCCCCCCCCCCCCHH		34.3628551015
975PhosphorylationEILDDGQSPKHTQSQ
HHCCCCCCCCCCCHH		41.2528551015
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
461SPhosphorylationKinasePRKACAP27791
GPS
461SPhosphorylationKinasePKA-FAMILY-GPS
461SPhosphorylationKinasePKA-Uniprot
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of NEB1_RAT !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of NEB1_RAT !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
TGON3_RATTgoln2physical
10514494
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of NEB1_RAT

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Regulation of neurabin I interaction with protein phosphatase 1 byphosphorylation.";
McAvoy T., Allen P.B., Obaishi H., Nakanishi H., Takai Y.,Greengard P., Nairn A.C., Hemmings H.C. Jr.;
Biochemistry 38:12943-12949(1999).
Cited for: INTERACTION WITH PP1, PHOSPHORYLATION AT SER-461, AND MUTAGENESIS.

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