dbPTM

TFPT_RAT - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TFPT_RAT
UniProt AC	Q9JMG6
Protein Name	TCF3 fusion partner homolog
Gene Name	Tfpt
Organism	Rattus norvegicus (Rat).
Sequence Length	259
Subcellular Localization	Nucleus .
Protein Description	Appears to promote apoptosis in a p53/TP53-independent manner.; Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair..
Protein Sequence	MELEQREGTMAAVGFEEFSAPPGSELALPPLFGGHILESELETEVEFVSGGLGDSGLRERDEEEEAARGRRRRQRELNRRKYQALGRRCREIEQVNERVLNRLHQVQRITRRLQQERRFLMRVLDSYGDDYRDSQFTIVLEDDGSQGTDVPTPGNVENEPPEKEGLSPPQRTTATLDPSSPAPGEGPSGRKRRRAPRAASSLTPELAPVQVGAEGWGQGVIKVEEDFGFEADEALDSSWVSRGPDKLLPYPTLASPPFD

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
167	Phosphorylation	PPEKEGLSPPQRTTA CCCCCCCCCCCCCCC	45.45	28432305
172	Phosphorylation	GLSPPQRTTATLDPS CCCCCCCCCCCCCCC	18.61	30181290
173	Phosphorylation	LSPPQRTTATLDPSS CCCCCCCCCCCCCCC	21.60	28689409
175	Phosphorylation	PPQRTTATLDPSSPA CCCCCCCCCCCCCCC	29.60	23984901
179	Phosphorylation	TTATLDPSSPAPGEG CCCCCCCCCCCCCCC	48.93	27097102
180	Phosphorylation	TATLDPSSPAPGEGP CCCCCCCCCCCCCCC	30.39	23712012
188	Phosphorylation	PAPGEGPSGRKRRRA CCCCCCCCHHHCCCC	63.19	28689409
200	Phosphorylation	RRAPRAASSLTPELA CCCCCHHHHCCCCCC	25.54	28689409
201	Phosphorylation	RAPRAASSLTPELAP CCCCHHHHCCCCCCC	31.38	28689409
203	Phosphorylation	PRAASSLTPELAPVQ CCHHHHCCCCCCCCE	19.37	28689409
222	Acetylation	GWGQGVIKVEEDFGF CCCCCEEEEEECCCC	40.98	25786129
250	Phosphorylation	GPDKLLPYPTLASPP CCCCCCCCCCCCCCC	14.60	28551015
252	Phosphorylation	DKLLPYPTLASPPFD CCCCCCCCCCCCCCC	29.16	30181290
255	Phosphorylation	LPYPTLASPPFD--- CCCCCCCCCCCC---	35.90	23712012

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of TFPT_RAT !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of TFPT_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TFPT_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
ARC_RAT	Arc	physical	10644725
PAWR_RAT	Pawr	physical	16229834

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TFPT_RAT

Related Literatures of Post-Translational Modification