TF2B1_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TF2B1_ARATH
• UniProt AC: P48512
• Protein Name: Transcription initiation factor IIB-1
• Gene Name: TFIIB1
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 312
• Subcellular Localization: Nucleus.
• Protein Description: General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA polymerase II (By similarity). Interacts with TBP2 and is required for activated transcription and possibly basal transcription. [PubMed: 10634912 Plays important roles in pollen tube growth, guidance, and reception as well as endosperm development. Is partially functionally different from TFIIB2 and PBRP2]
• Protein Sequence: MSDAYCTDCKKETELVVDHSAGDTLCSECGLVLESHSIDETSEWRTFANESSNSDPNRVGGPTNPLLADSALTTVIAKPNGSSGDFLSSSLGRWQNRNSNSDRGLIQAFKTIATMSERLGLVATIKDRANELYKRLEDQKSSRGRNQDALYAACLYIACRQEDKPRTIKEICVIANGATKKEIGRAKDYIVKTLGLEPGQSVDLGTIHAGDFMRRFCSNLAMSNHAVKAAQEAVQKSEEFDIRRSPISIAAVVIYIITQLSDDKKTLKDISHATGVAEGTIRNSYKDLYPHLSKIAPSWYAKEEDLKNLSSP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSDAYCTDC ------CCCCCCCCC	30.83	25561503
54	Phosphorylation	FANESSNSDPNRVGG HCCCCCCCCCCCCCC	57.29	29654922
310	Phosphorylation	EEDLKNLSSP----- HHHHHCCCCC-----	50.38	23776212
311	Phosphorylation	EDLKNLSSP------ HHHHCCCCC------	37.48	23776212

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TF2B1_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TF2B1_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TF2B1_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
BIN4_ARATH	BIN4	physical	20360860

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Large-scale Arabidopsis phosphoproteome profiling reveals novelchloroplast kinase substrates and phosphorylation networks.";
Reiland S., Messerli G., Baerenfaller K., Gerrits B., Endler A.,Grossmann J., Gruissem W., Baginsky S.;
Plant Physiol. 150:889-903(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-311, AND MASSSPECTROMETRY.
PubMed: 19376835