dbPTM

TEX2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TEX2_HUMAN
UniProt AC	Q8IWB9
Protein Name	Testis-expressed protein 2
Gene Name	TEX2
Organism	Homo sapiens (Human).
Sequence Length	1127
Subcellular Localization	Membrane Multi-pass membrane protein .
Protein Description
Protein Sequence	MTSLYGRHAEKTTDMPKPSAPKVHVQRSVSRDTIAIHFSASGEEEEEEEEEFREYFEEGLDDQSIVTGLEAKEDLYLEPQVGHDPAGPAASPVLADGLSVSQAPAILPVSKNTVKLLESPVPAAQVLSTVPLAVSPGSSSSGPLASSPSVSSLSEQKTSSSSPLSSPSKSPILSSSASTSTLSSAKPFMSLVKSLSTEVEPKESPHPARHRHLMKTLVKSLSTDTSRQESDTVSYKPPDSKLNLHLFKQFTQPRNTGGDSKTAPSSPLTSPSDTRSFFKVPEMEAKIEDTKRRLSEVIYEPFQLLSKIIGEESGSHRPKALSSSASELSNLSSLNGHLESNNNYSIKEEECDSEGDGYGSDSNIPRSDHPKSTGEPTREIELKSSQGSSLKDLGLKTSSLVLEKCSLSALVSKEDEEFCELYTEDFDLETEGESKVDKLSDIPLKPEVLAEDGVVLDSEDEVDSAVQHPELPVKTLGFFIMCVYVYLILPLPHYVSGLFLGIGLGFMTAVCVIWFFTPPSAHKYHKLHKNLRHWNTRSLDIKEPEILKGWMNEIYNYDPETYHATLTHSVFVRLEGGTLRLSKPNKNISRRASYNEPKPEVTYISQKIYDLSDSKIYLVPKTLARKRIWNKKYPICIELGQQDDFMSKAQTDKETSEEKPPAEGSEDPKKPPRPQEGTRSSQRDQILYLFGRTGREKEEWFRRFILASKLKSEIKKSSGVSGGKPGLLPAHSRHNSPSGHLTHSRSSSKGSVEEIMSQPKQKELAGSVRQKMLLDYSVYMGRCVPQESRSPQRSPLQSAESSPTAGKKLPEVPPSEEEEQEAWVNALLGRIFWDFLGEKYWSDLVSKKIQMKLSKIKLPYFMNELTLTELDMGVAVPKILQAFKPYVDHQGLWIDLEMSYNGSFLMTLETKMNLTKLGKEPLVEALKVGEIGKEGCRPRAFCLADSDEESSSAGSSEEDDAPEPSGGDKQLLPGAEGYVGGHRTSKIMRFVDKITKSKYFQKATETEFIKKKIEEVSNTPLLLTVEVQECRGTLAVNIPPPPTDRVWYGFRKPPHVELKARPKLGEREVTLVHVTDWIEKKLEQEFQKVFVMPNMDDVYITIMHSAMDPRSTSCLLKDPPVEAADQP

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
13	Phosphorylation	GRHAEKTTDMPKPSA CCCCCCCCCCCCCCC	41.17	24719451
19	Phosphorylation	TTDMPKPSAPKVHVQ CCCCCCCCCCCEEEE	64.43	20860994
28	Phosphorylation	PKVHVQRSVSRDTIA CCEEEEEEECCCEEE	13.83	26074081
30	Phosphorylation	VHVQRSVSRDTIAIH EEEEEEECCCEEEEE	26.19	26074081
76	Phosphorylation	LEAKEDLYLEPQVGH CHHCCCEEECCCCCC	22.72	28796482
91	Phosphorylation	DPAGPAASPVLADGL CCCCCCCCCCCCCCC	20.04	28387310
99	Phosphorylation	PVLADGLSVSQAPAI CCCCCCCCHHCCCEE	25.83	22210691
101	Phosphorylation	LADGLSVSQAPAILP CCCCCCHHCCCEEEE	19.76	22210691
119	Phosphorylation	NTVKLLESPVPAAQV CHHHHHCCCCCHHHH	31.03	22199227
128	Phosphorylation	VPAAQVLSTVPLAVS CCHHHHHHCCCEEEC	28.62	28270605
129	Phosphorylation	PAAQVLSTVPLAVSP CHHHHHHCCCEEECC	23.21	24173317
135	Phosphorylation	STVPLAVSPGSSSSG HCCCEEECCCCCCCC	20.24	22199227
138	Phosphorylation	PLAVSPGSSSSGPLA CEEECCCCCCCCCCC	30.36	28270605
139	Phosphorylation	LAVSPGSSSSGPLAS EEECCCCCCCCCCCC	34.14	28270605
140	Phosphorylation	AVSPGSSSSGPLASS EECCCCCCCCCCCCC	40.80	28270605
141	Phosphorylation	VSPGSSSSGPLASSP ECCCCCCCCCCCCCC	46.51	28270605
146	Phosphorylation	SSSGPLASSPSVSSL CCCCCCCCCCCHHHH	50.92	28270605
147	Phosphorylation	SSGPLASSPSVSSLS CCCCCCCCCCHHHHC	18.65	28270605
149	Phosphorylation	GPLASSPSVSSLSEQ CCCCCCCCHHHHCCC	36.26	22199227
151	Phosphorylation	LASSPSVSSLSEQKT CCCCCCHHHHCCCCC	29.87	22199227
152	Phosphorylation	ASSPSVSSLSEQKTS CCCCCHHHHCCCCCC	33.49	22199227
154	Phosphorylation	SPSVSSLSEQKTSSS CCCHHHHCCCCCCCC	39.67	24173317
158	Phosphorylation	SSLSEQKTSSSSPLS HHHCCCCCCCCCCCC	33.27	22199227
159	Phosphorylation	SLSEQKTSSSSPLSS HHCCCCCCCCCCCCC	34.95	28985074
160	Phosphorylation	LSEQKTSSSSPLSSP HCCCCCCCCCCCCCC	39.81	22199227
161	Phosphorylation	SEQKTSSSSPLSSPS CCCCCCCCCCCCCCC	35.42	25159151
162	Phosphorylation	EQKTSSSSPLSSPSK CCCCCCCCCCCCCCC	31.63	25159151
165	Phosphorylation	TSSSSPLSSPSKSPI CCCCCCCCCCCCCCC	43.52	25159151
166	Phosphorylation	SSSSPLSSPSKSPIL CCCCCCCCCCCCCCC	40.66	25159151
168	Phosphorylation	SSPLSSPSKSPILSS CCCCCCCCCCCCCCC	47.95	30576142
170	Phosphorylation	PLSSPSKSPILSSSA CCCCCCCCCCCCCCC	22.85	22199227
174	Phosphorylation	PSKSPILSSSASTST CCCCCCCCCCCCCCC	23.98	25159151
175	O-linked_Glycosylation	SKSPILSSSASTSTL CCCCCCCCCCCCCCH	26.86	28657654
175	Phosphorylation	SKSPILSSSASTSTL CCCCCCCCCCCCCCH	26.86	25159151
176	O-linked_Glycosylation	KSPILSSSASTSTLS CCCCCCCCCCCCCHH	23.90	28657654
176	Phosphorylation	KSPILSSSASTSTLS CCCCCCCCCCCCCHH	23.90	25159151
178	Phosphorylation	PILSSSASTSTLSSA CCCCCCCCCCCHHCC	25.49	25159151
179	Phosphorylation	ILSSSASTSTLSSAK CCCCCCCCCCHHCCH	26.00	25159151
180	Phosphorylation	LSSSASTSTLSSAKP CCCCCCCCCHHCCHH	25.51	23090842
181	Phosphorylation	SSSASTSTLSSAKPF CCCCCCCCHHCCHHH	30.65	28985074
183	Phosphorylation	SASTSTLSSAKPFMS CCCCCCHHCCHHHHH	28.48	23090842
184	Phosphorylation	ASTSTLSSAKPFMSL CCCCCHHCCHHHHHH	43.34	23090842
194	Phosphorylation	PFMSLVKSLSTEVEP HHHHHHHHHCCCCCC	21.77	30266825
196	Phosphorylation	MSLVKSLSTEVEPKE HHHHHHHCCCCCCCC	29.61	25159151
197	Phosphorylation	SLVKSLSTEVEPKES HHHHHHCCCCCCCCC	49.71	30266825
204	Phosphorylation	TEVEPKESPHPARHR CCCCCCCCCCHHHHH	34.34	25159151
215	Acetylation	ARHRHLMKTLVKSLS HHHHHHHHHHHHHHC	45.10	7964289
216	Phosphorylation	RHRHLMKTLVKSLST HHHHHHHHHHHHHCC	23.87	20068231
220	Phosphorylation	LMKTLVKSLSTDTSR HHHHHHHHHCCCCCC	21.77	23927012
222	Phosphorylation	KTLVKSLSTDTSRQE HHHHHHHCCCCCCCC	31.18	23401153
223	Phosphorylation	TLVKSLSTDTSRQES HHHHHHCCCCCCCCC	48.90	23927012
225	Phosphorylation	VKSLSTDTSRQESDT HHHHCCCCCCCCCCC	26.37	28450419
226	Phosphorylation	KSLSTDTSRQESDTV HHHCCCCCCCCCCCC	34.47	23927012
230	Phosphorylation	TDTSRQESDTVSYKP CCCCCCCCCCCCCCC	30.18	28450419
232	Phosphorylation	TSRQESDTVSYKPPD CCCCCCCCCCCCCCC	22.19	23403867
234	Phosphorylation	RQESDTVSYKPPDSK CCCCCCCCCCCCCCC	29.54	23927012
235	Phosphorylation	QESDTVSYKPPDSKL CCCCCCCCCCCCCCE	24.15	23927012
240	Phosphorylation	VSYKPPDSKLNLHLF CCCCCCCCCEEEEEH	44.83	23927012
256	Phosphorylation	QFTQPRNTGGDSKTA HHCCCCCCCCCCCCC	43.77	28450419
260	Phosphorylation	PRNTGGDSKTAPSSP CCCCCCCCCCCCCCC	34.87	23927012
262	Phosphorylation	NTGGDSKTAPSSPLT CCCCCCCCCCCCCCC	47.99	23401153
265	Phosphorylation	GDSKTAPSSPLTSPS CCCCCCCCCCCCCCC	41.97	23401153
266	Phosphorylation	DSKTAPSSPLTSPSD CCCCCCCCCCCCCCC	23.91	25159151
269	Phosphorylation	TAPSSPLTSPSDTRS CCCCCCCCCCCCCCC	41.81	30266825
270	Phosphorylation	APSSPLTSPSDTRSF CCCCCCCCCCCCCCC	30.04	25159151
272	Phosphorylation	SSPLTSPSDTRSFFK CCCCCCCCCCCCCCC	51.92	30266825
274	Phosphorylation	PLTSPSDTRSFFKVP CCCCCCCCCCCCCCC	32.33	23927012
276	Phosphorylation	TSPSDTRSFFKVPEM CCCCCCCCCCCCCHH	36.81	23090842
295	Phosphorylation	EDTKRRLSEVIYEPF HHHHHHHHHHHHHHH	28.18	25159151
299	Phosphorylation	RRLSEVIYEPFQLLS HHHHHHHHHHHHHHH	23.79	21945579
306	Phosphorylation	YEPFQLLSKIIGEES HHHHHHHHHHHCCCC	30.33	24719451
315	Phosphorylation	IIGEESGSHRPKALS HHCCCCCCCCCCHHH	26.13	-
323	Phosphorylation	HRPKALSSSASELSN CCCCHHHCCHHHHHC	30.67	-
330	N-linked_Glycosylation	SSASELSNLSSLNGH CCHHHHHCHHHHHCC	57.47	UniProtKB CARBOHYD
332	Phosphorylation	ASELSNLSSLNGHLE HHHHHCHHHHHCCCC	36.71	-
345	Phosphorylation	LESNNNYSIKEEECD CCCCCCCCCCHHHCC	29.34	24719451
353	Phosphorylation	IKEEECDSEGDGYGS CCHHHCCCCCCCCCC	55.95	23927012
358	Phosphorylation	CDSEGDGYGSDSNIP CCCCCCCCCCCCCCC	20.42	27732954
360	Phosphorylation	SEGDGYGSDSNIPRS CCCCCCCCCCCCCCC	29.40	23663014
362	Phosphorylation	GDGYGSDSNIPRSDH CCCCCCCCCCCCCCC	38.05	23663014
367	Phosphorylation	SDSNIPRSDHPKSTG CCCCCCCCCCCCCCC	34.61	28102081
372	Phosphorylation	PRSDHPKSTGEPTRE CCCCCCCCCCCCCEE	46.20	-
373	Phosphorylation	RSDHPKSTGEPTREI CCCCCCCCCCCCEEE	52.25	-
377	Phosphorylation	PKSTGEPTREIELKS CCCCCCCCEEEEEEC	36.31	-
383	Methylation	PTREIELKSSQGSSL CCEEEEEECCCCCCH	34.96	115971269
383	Ubiquitination	PTREIELKSSQGSSL CCEEEEEECCCCCCH	34.96	29967540
384	Phosphorylation	TREIELKSSQGSSLK CEEEEEECCCCCCHH	40.28	23312004
385	Phosphorylation	REIELKSSQGSSLKD EEEEEECCCCCCHHH	36.65	26657352
388	Phosphorylation	ELKSSQGSSLKDLGL EEECCCCCCHHHCCC	25.51	28857561
389	Phosphorylation	LKSSQGSSLKDLGLK EECCCCCCHHHCCCC	46.38	28857561
391	Ubiquitination	SSQGSSLKDLGLKTS CCCCCCHHHCCCCHH	53.51	29967540
397	Phosphorylation	LKDLGLKTSSLVLEK HHHCCCCHHHHHHHH	28.70	25072903
398	Phosphorylation	KDLGLKTSSLVLEKC HHCCCCHHHHHHHHC	21.78	23312004
399	Phosphorylation	DLGLKTSSLVLEKCS HCCCCHHHHHHHHCC	27.94	28857561
406	Phosphorylation	SLVLEKCSLSALVSK HHHHHHCCHHHHCCC	36.10	28555341
408	Phosphorylation	VLEKCSLSALVSKED HHHHCCHHHHCCCCC	11.85	25159151
440	Phosphorylation	ESKVDKLSDIPLKPE CCCCCCHHCCCCCHH	38.95	20363803
458	Phosphorylation	EDGVVLDSEDEVDSA CCCCEECCHHHHCHH	42.67	30278072
464	Phosphorylation	DSEDEVDSAVQHPEL CCHHHHCHHHCCCCC	35.20	28450419
538	Phosphorylation	LRHWNTRSLDIKEPE HCCCCCCCCCCCCHH	28.49	26657352
542	Ubiquitination	NTRSLDIKEPEILKG CCCCCCCCCHHHHHH	67.87	29967540
593	Phosphorylation	KNISRRASYNEPKPE CCCCCCCCCCCCCCC	27.04	25849741
594	Phosphorylation	NISRRASYNEPKPEV CCCCCCCCCCCCCCE	23.66	28985074
598	Ubiquitination	RASYNEPKPEVTYIS CCCCCCCCCCEEEEE	47.86	29967540
602	Phosphorylation	NEPKPEVTYISQKIY CCCCCCEEEEEEEEE	17.30	23312004
603	Phosphorylation	EPKPEVTYISQKIYD CCCCCEEEEEEEEEE	12.07	23312004
609	Phosphorylation	TYISQKIYDLSDSKI EEEEEEEEECCCCEE	20.19	20068231
612	Phosphorylation	SQKIYDLSDSKIYLV EEEEEECCCCEEEEE	36.62	20068231
614	Phosphorylation	KIYDLSDSKIYLVPK EEEECCCCEEEEEEH	19.99	20068231
633	Phosphorylation	KRIWNKKYPICIELG HHHCCCCCCEEEEEC	10.23	27470641
717	Phosphorylation	LKSEIKKSSGVSGGK HHHHHHHHCCCCCCC	27.59	23927012
718	Phosphorylation	KSEIKKSSGVSGGKP HHHHHHHCCCCCCCC	52.69	23186163
721	Phosphorylation	IKKSSGVSGGKPGLL HHHHCCCCCCCCCCC	45.41	23927012
732	Phosphorylation	PGLLPAHSRHNSPSG CCCCCCCCCCCCCCC	37.02	23927012
736	Phosphorylation	PAHSRHNSPSGHLTH CCCCCCCCCCCCCCC	17.83	30266825
738	Phosphorylation	HSRHNSPSGHLTHSR CCCCCCCCCCCCCCC	38.37	30266825
742	Phosphorylation	NSPSGHLTHSRSSSK CCCCCCCCCCCCCCC	16.48	23927012
744	Phosphorylation	PSGHLTHSRSSSKGS CCCCCCCCCCCCCCC	28.73	23927012
746	Phosphorylation	GHLTHSRSSSKGSVE CCCCCCCCCCCCCHH	41.81	30278072
747	Phosphorylation	HLTHSRSSSKGSVEE CCCCCCCCCCCCHHH	34.65	30278072
748	Phosphorylation	LTHSRSSSKGSVEEI CCCCCCCCCCCHHHH	42.13	23401153
751	Phosphorylation	SRSSSKGSVEEIMSQ CCCCCCCCHHHHHCC	30.05	30278072
757	Phosphorylation	GSVEEIMSQPKQKEL CCHHHHHCCHHHHHH	49.33	23927012
767	Phosphorylation	KQKELAGSVRQKMLL HHHHHCHHHHHHHHH	14.44	28857561
776	Phosphorylation	RQKMLLDYSVYMGRC HHHHHHHHHHHCCCC	10.45	24275569
788	Phosphorylation	GRCVPQESRSPQRSP CCCCCCCCCCCCCCC	32.58	27050516
790	Phosphorylation	CVPQESRSPQRSPLQ CCCCCCCCCCCCCCC	34.36	30266825
794	Phosphorylation	ESRSPQRSPLQSAES CCCCCCCCCCCCCCC	25.39	30266825
798	Phosphorylation	PQRSPLQSAESSPTA CCCCCCCCCCCCCCC	41.51	30266825
801	Phosphorylation	SPLQSAESSPTAGKK CCCCCCCCCCCCCCC	41.14	30266825
802	Phosphorylation	PLQSAESSPTAGKKL CCCCCCCCCCCCCCC	20.13	30266825
804	Phosphorylation	QSAESSPTAGKKLPE CCCCCCCCCCCCCCC	50.41	30266825
815	Phosphorylation	KLPEVPPSEEEEQEA CCCCCCCCHHHHHHH	52.12	28450419
840	Phosphorylation	WDFLGEKYWSDLVSK HHHHCHHHHHHHHHH	13.07	20049867
886	Phosphorylation	ILQAFKPYVDHQGLW HHHHHHCCCCCCCEE	21.07	23663014
899	Phosphorylation	LWIDLEMSYNGSFLM EEEEEEEEECCEEEE	13.18	23663014
900	Phosphorylation	WIDLEMSYNGSFLMT EEEEEEEECCEEEEE	23.41	23663014
903	Phosphorylation	LEMSYNGSFLMTLET EEEEECCEEEEEEEH	16.15	23663014
907	Phosphorylation	YNGSFLMTLETKMNL ECCEEEEEEEHHHCH	24.48	23663014
910	Phosphorylation	SFLMTLETKMNLTKL EEEEEEEHHHCHHHC	38.41	23663014
984	Phosphorylation	GYVGGHRTSKIMRFV CCCCCCCHHHHHHHH	28.79	27251275
985	Phosphorylation	YVGGHRTSKIMRFVD CCCCCCHHHHHHHHH	21.82	23917254
993	Ubiquitination	KIMRFVDKITKSKYF HHHHHHHHHHHHHHH	47.15	29967540
997	Phosphorylation	FVDKITKSKYFQKAT HHHHHHHHHHHHHHH	24.76	25278378
999	Phosphorylation	DKITKSKYFQKATET HHHHHHHHHHHHHHH	20.52	25278378
1000	Ubiquitination	KITKSKYFQKATETE HHHHHHHHHHHHHHH	7.45	29967540
1006	Phosphorylation	YFQKATETEFIKKKI HHHHHHHHHHHHHHH	31.66	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of TEX2_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of TEX2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TEX2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TEX2_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-295, AND MASSSPECTROMETRY.	19690332 [Abstract]
"Large-scale proteomics analysis of the human kinome."; Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.; Mol. Cell. Proteomics 8:1751-1764(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-717, AND MASSSPECTROMETRY.	19369195 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-162; SER-165; SER-266AND THR-269, AND MASS SPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-196; SER-266; SER-270AND SER-295, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Quantitative phosphoproteome profiling of Wnt3a-mediated signalingnetwork: indicating the involvement of ribonucleoside-diphosphatereductase M2 subunit phosphorylation at residue serine 20 in canonicalWnt signal transduction."; Tang L.-Y., Deng N., Wang L.-S., Dai J., Wang Z.-L., Jiang X.-S.,Li S.-J., Li L., Sheng Q.-H., Wu D.-Q., Li L., Zeng R.; Mol. Cell. Proteomics 6:1952-1967(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-609, AND MASSSPECTROMETRY.	17693683 [Abstract]