TET1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TET1_HUMAN
• UniProt AC: Q8NFU7
• Protein Name: Methylcytosine dioxygenase TET1
• Gene Name: TET1
• Organism: Homo sapiens (Human).
• Sequence Length: 2136
• Subcellular Localization: Nucleus .
• Protein Description: Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in active DNA demethylation. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. Methylation at the C5 position of cytosine bases is an epigenetic modification of the mammalian genome which plays an important role in transcriptional regulation. In addition to its role in DNA demethylation, plays a more general role in chromatin regulation. Preferentially binds to CpG-rich sequences at promoters of both transcriptionally active and Polycomb-repressed genes. Involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT. Also involved in transcription repression of a subset of genes through recruitment of transcriptional repressors to promoters. Involved in the balance between pluripotency and lineage commitment of cells it plays a role in embryonic stem cells maintenance and inner cell mass cell specification. Plays an important role in the tumorigenicity of glioblastoma cells. TET1-mediated production of 5hmC acts as a recruitment signal for the CHTOP-methylosome complex to selective sites on the chromosome, where it methylates H4R3 and activates the transcription of genes involved in glioblastomagenesis. [PubMed: 25284789]
• Protein Sequence: MSRSRHARPSRLVRKEDVNKKKKNSQLRKTTKGANKNVASVKTLSPGKLKQLIQERDVKKKTEPKPPVPVRSLLTRAGAARMNLDRTEVLFQNPESLTCNGFTMALRSTSLSRRLSQPPLVVAKSKKVPLSKGLEKQHDCDYKILPALGVKHSENDSVPMQDTQVLPDIETLIGVQNPSLLKGKSQETTQFWSQRVEDSKINIPTHSGPAAEILPGPLEGTRCGEGLFSEETLNDTSGSPKMFAQDTVCAPFPQRATPKVTSQGNPSIQLEELGSRVESLKLSDSYLDPIKSEHDCYPTSSLNKVIPDLNLRNCLALGGSTSPTSVIKFLLAGSKQATLGAKPDHQEAFEATANQQEVSDTTSFLGQAFGAIPHQWELPGADPVHGEALGETPDLPEIPGAIPVQGEVFGTILDQQETLGMSGSVVPDLPVFLPVPPNPIATFNAPSKWPEPQSTVSYGLAVQGAIQILPLGSGHTPQSSSNSEKNSLPPVMAISNVENEKQVHISFLPANTQGFPLAPERGLFHASLGIAQLSQAGPSKSDRGSSQVSVTSTVHVVNTTVVTMPVPMVSTSSSSYTTLLPTLEKKKRKRCGVCEPCQQKTNCGECTYCKNRKNSHQICKKRKCEELKKKPSVVVPLEVIKENKRPQREKKPKVLKADFDNKPVNGPKSESMDYSRCGHGEEQKLELNPHTVENVTKNEDSMTGIEVEKWTQNKKSQLTDHVKGDFSANVPEAEKSKNSEVDKKRTKSPKLFVQTVRNGIKHVHCLPAETNVSFKKFNIEEFGKTLENNSYKFLKDTANHKNAMSSVATDMSCDHLKGRSNVLVFQQPGFNCSSIPHSSHSIINHHASIHNEGDQPKTPENIPSKEPKDGSPVQPSLLSLMKDRRLTLEQVVAIEALTQLSEAPSENSSPSKSEKDEESEQRTASLLNSCKAILYTVRKDLQDPNLQGEPPKLNHCPSLEKQSSCNTVVFNGQTTTLSNSHINSATNQASTKSHEYSKVTNSLSLFIPKSNSSKIDTNKSIAQGIITLDNCSNDLHQLPPRNNEVEYCNQLLDSSKKLDSDDLSCQDATHTQIEEDVATQLTQLASIIKINYIKPEDKKVESTPTSLVTCNVQQKYNQEKGTIQQKPPSSVHNNHGSSLTKQKNPTQKKTKSTPSRDRRKKKPTVVSYQENDRQKWEKLSYMYGTICDIWIASKFQNFGQFCPHDFPTVFGKISSSTKIWKPLAQTRSIMQPKTVFPPLTQIKLQRYPESAEEKVKVEPLDSLSLFHLKTESNGKAFTDKAYNSQVQLTVNANQKAHPLTQPSSPPNQCANVMAGDDQIRFQQVVKEQLMHQRLPTLPGISHETPLPESALTLRNVNVVCSGGITVVSTKSEEEVCSSSFGTSEFSTVDSAQKNFNDYAMNFFTNPTKNLVSITKDSELPTCSCLDRVIQKDKGPYYTHLGAGPSVAAVREIMENRYGQKGNAIRIEIVVYTGKEGKSSHGCPIAKWVLRRSSDEEKVLCLVRQRTGHHCPTAVMVVLIMVWDGIPLPMADRLYTELTENLKSYNGHPTDRRCTLNENRTCTCQGIDPETCGASFSFGCSWSMYFNGCKFGRSPSPRRFRIDPSSPLHEKNLEDNLQSLATRLAPIYKQYAPVAYQNQVEYENVARECRLGSKEGRPFSGVTACLDFCAHPHRDIHNMNNGSTVVCTLTREDNRSLGVIPQDEQLHVLPLYKLSDTDEFGSKEGMEAKIKSGAIEVLAPRRKKRTCFTQPVPRSGKKRAAMMTEVLAHKIRAVEKKPIPRIKRKNNSTTTNNSKPSSLPTLGSNTETVQPEVKSETEPHFILKSSDNTKTYSLMPSAPHPVKEASPGFSWSPKTASATPAPLKNDATASCGFSERSSTPHCTMPSGRLSGANAAAADGPGISQLGEVAPLPTLSAPVMEPLINSEPSTGVTEPLTPHQPNHQPSFLTSPQDLASSPMEEDEQHSEADEPPSDEPLSDDPLSPAEEKLPHIDEYWSDSEHIFLDANIGGVAIAPAHGSVLIECARRELHATTPVEHPNRNHPTRLSLVFYQHKNLNKPQHGFELNKIKFEAKEAKNKKMKASEQKDQAANEGPEQSSEVNELNQIPSHKALTLTHDNVVTVSPYALTHVAGPYNHWV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Phosphorylation	RSRHARPSRLVRKED CCCCCCHHHCCCHHH	32.47	17081983
30	Phosphorylation	KNSQLRKTTKGANKN HHHHHHHHHCCCCCC	27.57	-
31	Phosphorylation	NSQLRKTTKGANKNV HHHHHHHHCCCCCCC	30.43	-
43	Phosphorylation	KNVASVKTLSPGKLK CCCEECEECCHHHHH	30.25	26699800
45	Phosphorylation	VASVKTLSPGKLKQL CEECEECCHHHHHHH	36.52	24719451
48	Acetylation	VKTLSPGKLKQLIQE CEECCHHHHHHHHHH	56.76	25953088
72	Phosphorylation	KPPVPVRSLLTRAGA CCCCCHHHHHHHHCH	28.15	24719451
87	Phosphorylation	ARMNLDRTEVLFQNP HHCCCCCCEEEECCH	30.06	22210691
96	Phosphorylation	VLFQNPESLTCNGFT EEECCHHHCCCCCCH	30.18	22210691
98	Phosphorylation	FQNPESLTCNGFTMA ECCHHHCCCCCCHHH	17.13	29759185
108	Phosphorylation	GFTMALRSTSLSRRL CCHHHHHHHCHHHHH	24.17	22210691
112	Phosphorylation	ALRSTSLSRRLSQPP HHHHHCHHHHHCCCC	18.34	29759185
116	Phosphorylation	TSLSRRLSQPPLVVA HCHHHHHCCCCEEEE	38.54	24719451
179	Phosphorylation	LIGVQNPSLLKGKSQ HHCCCCHHHHCCCCH	54.61	24719451
185	Phosphorylation	PSLLKGKSQETTQFW HHHHCCCCHHHHHHH	41.75	29970186
188	Phosphorylation	LKGKSQETTQFWSQR HCCCCHHHHHHHHHH	20.47	29970186
189	Phosphorylation	KGKSQETTQFWSQRV CCCCHHHHHHHHHHH	22.48	-
193	Phosphorylation	QETTQFWSQRVEDSK HHHHHHHHHHHHHCC	14.92	-
232	Phosphorylation	EGLFSEETLNDTSGS CCCCCCCCCCCCCCC	27.15	29449344
236	Phosphorylation	SEETLNDTSGSPKMF CCCCCCCCCCCCCCC	33.63	29449344
237	Phosphorylation	EETLNDTSGSPKMFA CCCCCCCCCCCCCCC	39.89	29449344
239	Phosphorylation	TLNDTSGSPKMFAQD CCCCCCCCCCCCCCC	22.55	28165663
285	Phosphorylation	ESLKLSDSYLDPIKS HEECCCHHHCCCCCC	24.99	28787133
292	Phosphorylation	SYLDPIKSEHDCYPT HHCCCCCCCCCCCCC	40.66	28787133
320	Phosphorylation	NCLALGGSTSPTSVI CCHHCCCCCCCHHHH	24.74	29978859
321	Phosphorylation	CLALGGSTSPTSVIK CHHCCCCCCCHHHHH	41.84	29978859
322	Phosphorylation	LALGGSTSPTSVIKF HHCCCCCCCHHHHHH	28.07	29978859
324	Phosphorylation	LGGSTSPTSVIKFLL CCCCCCCHHHHHHHH	35.08	29978859
325	Phosphorylation	GGSTSPTSVIKFLLA CCCCCCHHHHHHHHC	25.81	29978859
582	Phosphorylation	SYTTLLPTLEKKKRK CCCCCHHHHHHHCCC	47.74	24173317
669	Phosphorylation	KPVNGPKSESMDYSR CCCCCCCCCCCCCCC	37.73	-
691	Phosphorylation	KLELNPHTVENVTKN CCCCCCCCCCCCCCC	30.67	22468782
701	Phosphorylation	NVTKNEDSMTGIEVE CCCCCCCCCCCCEEE	16.44	28509920
703	Phosphorylation	TKNEDSMTGIEVEKW CCCCCCCCCCEEEHH	38.67	27732954
746	Phosphorylation	SEVDKKRTKSPKLFV CHHHHCCCCCCHHHH	44.76	24719451
805	Phosphorylation	ANHKNAMSSVATDMS HCCHHHHHHHHHHCC	21.17	-
806	Phosphorylation	NHKNAMSSVATDMSC CCHHHHHHHHHHCCC	11.59	-
858	O-linked_Glycosylation	NEGDQPKTPENIPSK CCCCCCCCCCCCCCC	42.38	28411811
858	Phosphorylation	NEGDQPKTPENIPSK CCCCCCCCCCCCCCC	42.38	30576142
864	O-linked_Glycosylation	KTPENIPSKEPKDGS CCCCCCCCCCCCCCC	45.94	28411811
864	Phosphorylation	KTPENIPSKEPKDGS CCCCCCCCCCCCCCC	45.94	24719451
871	Phosphorylation	SKEPKDGSPVQPSLL CCCCCCCCCCCHHHH	31.84	12124344
905	Phosphorylation	TQLSEAPSENSSPSK HHHHCCCCCCCCCCC	57.36	24173317
908	Phosphorylation	SEAPSENSSPSKSEK HCCCCCCCCCCCCCC	39.30	24173317
909	Phosphorylation	EAPSENSSPSKSEKD CCCCCCCCCCCCCCC	44.78	24173317
935	Phosphorylation	NSCKAILYTVRKDLQ HHHHHHHHHHHHHCC	9.33	-
1086	Phosphorylation	TQLTQLASIIKINYI HHHHHHHHHHEEEEC	33.18	24719451
1129	Phosphorylation	TIQQKPPSSVHNNHG CCCCCCCCCCCCCCC	54.22	29978859
1130	Phosphorylation	IQQKPPSSVHNNHGS CCCCCCCCCCCCCCC	32.92	29978859
1137	Phosphorylation	SVHNNHGSSLTKQKN CCCCCCCCCCCCCCC	18.02	29978859
1138	Phosphorylation	VHNNHGSSLTKQKNP CCCCCCCCCCCCCCC	44.65	29978859
1140	Phosphorylation	NNHGSSLTKQKNPTQ CCCCCCCCCCCCCCC	33.12	29978859
1146	Phosphorylation	LTKQKNPTQKKTKST CCCCCCCCCCCCCCC	63.51	29978859
1150	Phosphorylation	KNPTQKKTKSTPSRD CCCCCCCCCCCCCCC	36.94	20363803
1155	Phosphorylation	KKTKSTPSRDRRKKK CCCCCCCCCCCCCCC	47.07	20363803
1161	Acetylation	PSRDRRKKKPTVVSY CCCCCCCCCCEEEEC	63.27	130749
1215	Phosphorylation	TVFGKISSSTKIWKP CCCCCCCCCCCCCHH	45.56	23898821
1216	Phosphorylation	VFGKISSSTKIWKPL CCCCCCCCCCCCHHH	27.25	29449344
1217	Phosphorylation	FGKISSSTKIWKPLA CCCCCCCCCCCHHHC	28.62	29449344
1228	Phosphorylation	KPLAQTRSIMQPKTV HHHCCCCCCCCCCCC	26.29	-
1234	Phosphorylation	RSIMQPKTVFPPLTQ CCCCCCCCCCCCCHH	33.78	-
1282	Phosphorylation	KAFTDKAYNSQVQLT CEECCHHHCCCEEEE	22.53	25690035
1284	Phosphorylation	FTDKAYNSQVQLTVN ECCHHHCCCEEEEEC	21.03	25690035
1300	Phosphorylation	NQKAHPLTQPSSPPN CCCCCCCCCCCCCCC	42.77	30377224
1303	Phosphorylation	AHPLTQPSSPPNQCA CCCCCCCCCCCCCCC	45.73	30624053
1304	Phosphorylation	HPLTQPSSPPNQCAN CCCCCCCCCCCCCCC	51.57	30624053
1361	Phosphorylation	RNVNVVCSGGITVVS CCCEEEECCCEEEEC	28.57	22199227
1365	Phosphorylation	VVCSGGITVVSTKSE EEECCCEEEECCCCH	20.38	22199227
1368	Phosphorylation	SGGITVVSTKSEEEV CCCEEEECCCCHHHH	26.28	22199227
1369	Phosphorylation	GGITVVSTKSEEEVC CCEEEECCCCHHHHH	27.29	22199227
1382	Phosphorylation	VCSSSFGTSEFSTVD HHHCCCCCCCCCCHH	24.07	-
1492	O-linked_Glycosylation	AKWVLRRSSDEEKVL HHHHHHCCCCHHHEE	35.39	28411811
1589	Ubiquitination	SMYFNGCKFGRSPSP EEEECCCCCCCCCCC	52.86	-
1593	Phosphorylation	NGCKFGRSPSPRRFR CCCCCCCCCCCCCCC	30.06	24173317
1595	Phosphorylation	CKFGRSPSPRRFRID CCCCCCCCCCCCCCC	32.08	17081983
1604	Phosphorylation	RRFRIDPSSPLHEKN CCCCCCCCCCHHHCC	40.62	22210691
1605	Phosphorylation	RFRIDPSSPLHEKNL CCCCCCCCCHHHCCH	36.55	22210691
1641	Phosphorylation	AYQNQVEYENVAREC CCCCCCCCHHHHHHH	17.59	19835603
1662	Phosphorylation	GRPFSGVTACLDFCA CCCCCCCCHHHHHHC	18.38	22210691
1682	Phosphorylation	IHNMNNGSTVVCTLT CCCCCCCCEEEEEEE	21.83	22210691
1731	Phosphorylation	GMEAKIKSGAIEVLA HHHHHHHCCCEEEEC	36.61	24505115
1745	Phosphorylation	APRRKKRTCFTQPVP CCCCCCCCCCCCCCC	22.35	26699800
1748	Phosphorylation	RKKRTCFTQPVPRSG CCCCCCCCCCCCCCC	33.82	26699800
1769	Ubiquitination	MTEVLAHKIRAVEKK HHHHHHHHHHHHHCC	28.42	-
1789	Phosphorylation	KRKNNSTTTNNSKPS CCCCCCCCCCCCCCC	27.61	22210691
1797	Phosphorylation	TNNSKPSSLPTLGSN CCCCCCCCCCCCCCC	47.06	22210691
1800	Phosphorylation	SKPSSLPTLGSNTET CCCCCCCCCCCCCCC	49.39	22210691
1805	Phosphorylation	LPTLGSNTETVQPEV CCCCCCCCCCCCCCC	34.43	25003641
1845	Phosphorylation	PHPVKEASPGFSWSP CCCCCCCCCCCCCCC	27.01	27732954
1849	Phosphorylation	KEASPGFSWSPKTAS CCCCCCCCCCCCCCC	32.34	27732954
1851	Phosphorylation	ASPGFSWSPKTASAT CCCCCCCCCCCCCCC	18.47	29978859
1867	Phosphorylation	APLKNDATASCGFSE CCCCCCCCCCCCCCC	23.20	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TET1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TET1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TET1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DCAF1_HUMAN	VPRBP	physical	25557551
DDB1_HUMAN	DDB1	physical	25557551

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.