dbPTM

TENA_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TENA_HUMAN
UniProt AC	P24821
Protein Name	Tenascin
Gene Name	TNC
Organism	Homo sapiens (Human).
Sequence Length	2201
Subcellular Localization	Secreted, extracellular space, extracellular matrix.
Protein Description	Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6. In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells. [PubMed: 19884327]
Protein Sequence	MGAMTQLLAGVFLAFLALATEGGVLKKVIRHKRQSGVNATLPEENQPVVFNHVYNIKLPVGSQCSVDLESASGEKDLAPPSEPSESFQEHTVDGENQIVFTHRINIPRRACGCAAAPDVKELLSRLEELENLVSSLREQCTAGAGCCLQPATGRLDTRPFCSGRGNFSTEGCGCVCEPGWKGPNCSEPECPGNCHLRGRCIDGQCICDDGFTGEDCSQLACPSDCNDQGKCVNGVCICFEGYAGADCSREICPVPCSEEHGTCVDGLCVCHDGFAGDDCNKPLCLNNCYNRGRCVENECVCDEGFTGEDCSELICPNDCFDRGRCINGTCYCEEGFTGEDCGKPTCPHACHTQGRCEEGQCVCDEGFAGVDCSEKRCPADCHNRGRCVDGRCECDDGFTGADCGELKCPNGCSGHGRCVNGQCVCDEGYTGEDCSQLRCPNDCHSRGRCVEGKCVCEQGFKGYDCSDMSCPNDCHQHGRCVNGMCVCDDGYTGEDCRDRQCPRDCSNRGLCVDGQCVCEDGFTGPDCAELSCPNDCHGQGRCVNGQCVCHEGFMGKDCKEQRCPSDCHGQGRCVDGQCICHEGFTGLDCGQHSCPSDCNNLGQCVSGRCICNEGYSGEDCSEVSPPKDLVVTEVTEETVNLAWDNEMRVTEYLVVYTPTHEGGLEMQFRVPGDQTSTIIQELEPGVEYFIRVFAILENKKSIPVSARVATYLPAPEGLKFKSIKETSVEVEWDPLDIAFETWEIIFRNMNKEDEGEITKSLRRPETSYRQTGLAPGQEYEISLHIVKNNTRGPGLKRVTTTRLDAPSQIEVKDVTDTTALITWFKPLAEIDGIELTYGIKDVPGDRTTIDLTEDENQYSIGNLKPDTEYEVSLISRRGDMSSNPAKETFTTGLDAPRNLRRVSQTDNSITLEWRNGKAAIDSYRIKYAPISGGDHAEVDVPKSQQATTKTTLTGLRPGTEYGIGVSAVKEDKESNPATINAATELDTPKDLQVSETAETSLTLLWKTPLAKFDRYRLNYSLPTGQWVGVQLPRNTTSYVLRGLEPGQEYNVLLTAEKGRHKSKPARVKASTEQAPELENLTVTEVGWDGLRLNWTAADQAYEHFIIQVQEANKVEAARNLTVPGSLRAVDIPGLKAATPYTVSIYGVIQGYRTPVLSAEASTGETPNLGEVVVAEVGWDALKLNWTAPEGAYEYFFIQVQEADTVEAAQNLTVPGGLRSTDLPGLKAATHYTITIRGVTQDFSTTPLSVEVLTEEVPDMGNLTVTEVSWDALRLNWTTPDGTYDQFTIQVQEADQVEEAHNLTVPGSLRSMEIPGLRAGTPYTVTLHGEVRGHSTRPLAVEVVTEDLPQLGDLAVSEVGWDGLRLNWTAADNAYEHFVIQVQEVNKVEAAQNLTLPGSLRAVDIPGLEAATPYRVSIYGVIRGYRTPVLSAEASTAKEPEIGNLNVSDITPESFNLSWMATDGIFETFTIEIIDSNRLLETVEYNISGAERTAHISGLPPSTDFIVYLSGLAPSIRTKTISATATTEALPLLENLTISDINPYGFTVSWMASENAFDSFLVTVVDSGKLLDPQEFTLSGTQRKLELRGLITGIGYEVMVSGFTQGHQTKPLRAEIVTEAEPEVDNLLVSDATPDGFRLSWTADEGVFDNFVLKIRDTKKQSEPLEITLLAPERTRDITGLREATEYEIELYGISKGRRSQTVSAIATTAMGSPKEVIFSDITENSATVSWRAPTAQVESFRITYVPITGGTPSMVTVDGTKTQTRLVKLIPGVEYLVSIIAMKGFEESEPVSGSFTTALDGPSGLVTANITDSEALARWQPAIATVDSYVISYTGEKVPEITRTVSGNTVEYALTDLEPATEYTLRIFAEKGPQKSSTITAKFTTDLDSPRDLTATEVQSETALLTWRPPRASVTGYLLVYESVDGTVKEVIVGPDTTSYSLADLSPSTHYTAKIQALNGPLRSNMIQTIFTTIGLLYPFPKDCSQAMLNGDTTSGLYTIYLNGDKAEALEVFCDMTSDGGGWIVFLRRKNGRENFYQNWKAYAAGFGDRREEFWLGLDNLNKITAQGQYELRVDLRDHGETAFAVYDKFSVGDAKTRYKLKVEGYSGTAGDSMAYHNGRSFSTFDKDTDSAITNCALSYKGAFWYRNCHRVNLMGRYGDNNHSQGVNWFHWKGHEHSIQFAEMKLRPSNFRNLEGRRKRA

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MGAMTQLLAGVF ---CCHHHHHHHHHH	18.61	24043423
20	Phosphorylation	LAFLALATEGGVLKK HHHHHHHHCCCHHHH	35.69	24043423
38	N-linked_Glycosylation	HKRQSGVNATLPEEN HHHHCCCCCCCCCCC	30.63	UniProtKB CARBOHYD
62	Phosphorylation	NIKLPVGSQCSVDLE EEECCCCCCEEEECH	28.40	23927012
65	Phosphorylation	LPVGSQCSVDLESAS CCCCCCEEEECHHCC	15.84	22777824
70	Phosphorylation	QCSVDLESASGEKDL CEEEECHHCCCCCCC	34.72	29255136
72	Phosphorylation	SVDLESASGEKDLAP EEECHHCCCCCCCCC	57.68	29255136
81	O-linked_Glycosylation	EKDLAPPSEPSESFQ CCCCCCCCCCCHHHH	62.17	OGP
81	Phosphorylation	EKDLAPPSEPSESFQ CCCCCCCCCCCHHHH	62.17	26657352
84	O-linked_Glycosylation	LAPPSEPSESFQEHT CCCCCCCCHHHHEEC	41.65	OGP
84	Phosphorylation	LAPPSEPSESFQEHT CCCCCCCCHHHHEEC	41.65	26657352
86	Phosphorylation	PPSEPSESFQEHTVD CCCCCCHHHHEECCC	36.25	26657352
91	O-linked_Glycosylation	SESFQEHTVDGENQI CHHHHEECCCCCCEE	21.38	OGP
91	Phosphorylation	SESFQEHTVDGENQI CHHHHEECCCCCCEE	21.38	28348404
124	Phosphorylation	PDVKELLSRLEELEN CCHHHHHHHHHHHHH	47.66	24719451
134	Phosphorylation	EELENLVSSLREQCT HHHHHHHHHHHHHHH	27.16	24719451
135	Phosphorylation	ELENLVSSLREQCTA HHHHHHHHHHHHHHC	24.78	24719451
166	N-linked_Glycosylation	PFCSGRGNFSTEGCG CCCCCCCCCCCCCCC	26.74	UniProtKB CARBOHYD
168	Phosphorylation	CSGRGNFSTEGCGCV CCCCCCCCCCCCCCE	29.55	26657352
169	Phosphorylation	SGRGNFSTEGCGCVC CCCCCCCCCCCCCEE	32.05	26657352
184	N-linked_Glycosylation	EPGWKGPNCSEPECP CCCCCCCCCCCCCCC	51.09	18780401
257	Phosphorylation	EICPVPCSEEHGTCV EECCCCCCCCCCCEE	39.69	27251275
327	N-linked_Glycosylation	FDRGRCINGTCYCEE CCCCCCCCCEEEECC	43.26	UniProtKB CARBOHYD
453 (in isoform 2)	Ubiquitination	-	15.25	-
461 (in isoform 2)	Ubiquitination	-	64.48	-
491	Phosphorylation	MCVCDDGYTGEDCRD EEEECCCCCCCCCCC	20.68	-
616	Phosphorylation	CICNEGYSGEDCSEV EEECCCCCCCCCCCC	46.71	26657352
719	Acetylation	LPAPEGLKFKSIKET ECCCCCCCCCCCEEC	62.70	11922513
788	N-linked_Glycosylation	ISLHIVKNNTRGPGL EEEEEEECCCCCCCC	44.18	UniProtKB CARBOHYD
799	Phosphorylation	GPGLKRVTTTRLDAP CCCCEEEEECCCCCC	26.87	23312004
800	Phosphorylation	PGLKRVTTTRLDAPS CCCEEEEECCCCCCC	13.68	28857561
801	Phosphorylation	GLKRVTTTRLDAPSQ CCEEEEECCCCCCCC	21.62	23312004
859	Phosphorylation	TEDENQYSIGNLKPD CCCCCEEECCCCCCC	17.79	22210691
872	Phosphorylation	PDTEYEVSLISRRGD CCCCEEEEEEECCCC	14.19	22210691
875	Phosphorylation	EYEVSLISRRGDMSS CEEEEEEECCCCCCC	22.63	24719451
903	Phosphorylation	PRNLRRVSQTDNSIT CCCCCCCCCCCCCEE	26.08	28857561
905	Phosphorylation	NLRRVSQTDNSITLE CCCCCCCCCCCEEEE	29.64	23936043
908	Phosphorylation	RVSQTDNSITLEWRN CCCCCCCCEEEEECC	21.54	28857561
953	Phosphorylation	ATTKTTLTGLRPGTE CCCEEECCCCCCCCC	31.88	24719451
1007	Phosphorylation	SLTLLWKTPLAKFDR HEEEEECCCCHHCCE	16.38	-
1018	N-linked_Glycosylation	KFDRYRLNYSLPTGQ HCCEEEEEEECCCCC	18.49	19159218
1019	Phosphorylation	FDRYRLNYSLPTGQW CCEEEEEEECCCCCE	19.04	-
1020	Phosphorylation	DRYRLNYSLPTGQWV CEEEEEEECCCCCEE	27.14	-
1023	Phosphorylation	RLNYSLPTGQWVGVQ EEEEECCCCCEEEEE	47.50	-
1034	N-linked_Glycosylation	VGVQLPRNTTSYVLR EEEECCCCCCCEEEC	45.85	19159218
1035	O-linked_Glycosylation	GVQLPRNTTSYVLRG EEECCCCCCCEEECC	20.56	23301498
1037	O-linked_Glycosylation	QLPRNTTSYVLRGLE ECCCCCCCEEECCCC	15.94	23301498
1079	N-linked_Glycosylation	EQAPELENLTVTEVG CCCCCHHCCEEEEEE	54.35	18780401
1093	N-linked_Glycosylation	GWDGLRLNWTAADQA ECCCEEEECCHHHHH	27.84	18780401
1119	N-linked_Glycosylation	NKVEAARNLTVPGSL CCHHHHHCCCCCCCC	35.02	UniProtKB CARBOHYD
1138	Phosphorylation	IPGLKAATPYTVSIY CCCCCCCCCEEEEEE	22.99	28270605
1140	Phosphorylation	GLKAATPYTVSIYGV CCCCCCCEEEEEEEE	18.54	28270605
1141	Phosphorylation	LKAATPYTVSIYGVI CCCCCCEEEEEEEEE	14.69	28270605
1143	Phosphorylation	AATPYTVSIYGVIQG CCCCEEEEEEEEECC	11.42	28270605
1145	Phosphorylation	TPYTVSIYGVIQGYR CCEEEEEEEEECCCC	9.61	28270605
1184	N-linked_Glycosylation	GWDALKLNWTAPEGA ECCEEECCEECCCCC	32.25	19159218
1210	N-linked_Glycosylation	DTVEAAQNLTVPGGL CCHHHHHCCCCCCCC	32.71	UniProtKB CARBOHYD
1261	N-linked_Glycosylation	EEVPDMGNLTVTEVS CCCCCCCCEEEEEEE	26.38	18780401
1265	O-linked_Glycosylation	DMGNLTVTEVSWDAL CCCCEEEEEEEECEE	25.98	OGP
1275	N-linked_Glycosylation	SWDALRLNWTTPDGT EECEEECCEECCCCC	27.84	19159218
1301	N-linked_Glycosylation	DQVEEAHNLTVPGSL HHHHHHHCCCCCCCC	44.44	18780401
1310	Phosphorylation	TVPGSLRSMEIPGLR CCCCCCEECCCCCCC	26.51	27251275
1366	N-linked_Glycosylation	GWDGLRLNWTAADNA CCCCEEEEEEECCCH	27.84	19159218
1392	N-linked_Glycosylation	NKVEAAQNLTLPGSL CCEEHHHCCCCCCCE	30.21	UniProtKB CARBOHYD
1394	Phosphorylation	VEAAQNLTLPGSLRA EEHHHCCCCCCCEEE	38.16	26074081
1398	Phosphorylation	QNLTLPGSLRAVDIP HCCCCCCCEEEEECC	16.85	26074081
1411	Phosphorylation	IPGLEAATPYRVSIY CCCCCCCCCEEEEEE	28.09	22210691
1413	Phosphorylation	GLEAATPYRVSIYGV CCCCCCCEEEEEEEE	21.20	22210691
1418	Phosphorylation	TPYRVSIYGVIRGYR CCEEEEEEEEECCCC	9.61	-
1445	N-linked_Glycosylation	EPEIGNLNVSDITPE CCCCCCCCHHHCCCC	34.93	UniProtKB CARBOHYD
1455	N-linked_Glycosylation	DITPESFNLSWMATD HCCCCCCCEEEEECC	42.30	UniProtKB CARBOHYD
1469	O-linked_Glycosylation	DGIFETFTIEIIDSN CCCCEEEEEEEECCC	25.72	OGP
1485	N-linked_Glycosylation	LLETVEYNISGAERT EEEEEEEECCCHHHE	14.40	18780401
1492	Phosphorylation	NISGAERTAHISGLP ECCCHHHEEECCCCC	17.69	-
1502	Phosphorylation	ISGLPPSTDFIVYLS CCCCCCCCCEEEEEC	40.48	-
1534	N-linked_Glycosylation	EALPLLENLTISDIN CHHHHHHCCEECCCC	42.31	UniProtKB CARBOHYD
1678	Phosphorylation	PERTRDITGLREATE CCCCCCCCCCCCCEE	34.16	24719451
1699	Phosphorylation	GISKGRRSQTVSAIA EECCCCCCCCHHHHH	28.92	-
1701	Phosphorylation	SKGRRSQTVSAIATT CCCCCCCCHHHHHHH	20.06	-
1703	Phosphorylation	GRRSQTVSAIATTAM CCCCCCHHHHHHHCC	19.83	-
1729	Phosphorylation	TENSATVSWRAPTAQ CCCCCEEEEECCCCE	13.39	22210691
1751	Phosphorylation	YVPITGGTPSMVTVD EEECCCCCCCEEEEC	17.34	-
1760	Phosphorylation	SMVTVDGTKTQTRLV CEEEECCCCCCEEEE	26.84	-
1775	Phosphorylation	KLIPGVEYLVSIIAM HHCCCHHHHHHHHHC	15.25	-
1778	Phosphorylation	PGVEYLVSIIAMKGF CCHHHHHHHHHCCCC	12.99	22496350
1809	N-linked_Glycosylation	PSGLVTANITDSEAL CCCEEEECCCCHHHH	28.47	16335952
1825	O-linked_Glycosylation	RWQPAIATVDSYVIS HCCCEEEEECEEEEE	20.80	OGP
1842	Phosphorylation	GEKVPEITRTVSGNT CCCCCEEEEEECCCE	20.73	-
1844	Phosphorylation	KVPEITRTVSGNTVE CCCEEEEEECCCEEE	15.46	-
1846	Phosphorylation	PEITRTVSGNTVEYA CEEEEEECCCEEEEE	26.22	-
1864	Phosphorylation	LEPATEYTLRIFAEK CCCCCEEEEEEEEEC	11.88	24719451
1878	Phosphorylation	KGPQKSSTITAKFTT CCCCCCCEEEEEEEC	29.45	22817900
1885	Phosphorylation	TITAKFTTDLDSPRD EEEEEEECCCCCCCC	37.38	22817900
1889	Phosphorylation	KFTTDLDSPRDLTAT EEECCCCCCCCCCCC	29.18	22817900
1902	Phosphorylation	ATEVQSETALLTWRP CCEECCCEEEEEECC	28.05	20166139
1906	Phosphorylation	QSETALLTWRPPRAS CCCEEEEEECCCCCE	21.93	20166139
1937	Phosphorylation	EVIVGPDTTSYSLAD EEEECCCCCCCCHHC	22.30	28270605
1938	Phosphorylation	VIVGPDTTSYSLADL EEECCCCCCCCHHCC	32.80	28270605
1939	Phosphorylation	IVGPDTTSYSLADLS EECCCCCCCCHHCCC	18.15	28270605
1940	Phosphorylation	VGPDTTSYSLADLSP ECCCCCCCCHHCCCC	12.95	28270605
1941	Phosphorylation	GPDTTSYSLADLSPS CCCCCCCCHHCCCCC	19.49	28270605
1946	Phosphorylation	SYSLADLSPSTHYTA CCCHHCCCCCCCHHH	19.83	28270605
1948	Phosphorylation	SLADLSPSTHYTAKI CHHCCCCCCCHHHHH	25.17	28270605
1949	Phosphorylation	LADLSPSTHYTAKIQ HHCCCCCCCHHHHHH	23.45	28270605
1951	Phosphorylation	DLSPSTHYTAKIQAL CCCCCCCHHHHHHHH	14.42	28270605
1952	Phosphorylation	LSPSTHYTAKIQALN CCCCCCHHHHHHHHC	17.55	28270605
2070	Phosphorylation	KITAQGQYELRVDLR CEECCCEEEEEEECC	24.61	-
2129	Phosphorylation	FSTFDKDTDSAITNC CCCCCCCCCCHHHHH	37.28	-
2134	Phosphorylation	KDTDSAITNCALSYK CCCCCHHHHHHHHCC	24.78	25867546
2139	Phosphorylation	AITNCALSYKGAFWY HHHHHHHHCCCCEEE	13.28	25867546
2140	Phosphorylation	ITNCALSYKGAFWYR HHHHHHHCCCCEEEC	17.81	25867546
2162	N-linked_Glycosylation	MGRYGDNNHSQGVNW EEEECCCCCCCCCCE	40.71	18780401

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
72	S	Phosphorylation	Kinase	FAM20C	Q8IXL6	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of TENA_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TENA_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
NCAN_HUMAN	NCAN	physical	9341124

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
615629	Deafness, autosomal dominant, 56 (DFNA56)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TENA_HUMAN

Related Literatures of Post-Translational Modification

N-linked Glycosylation
Reference	PubMed
"Glycoproteomics analysis of human liver tissue by combination ofmultiple enzyme digestion and hydrazide chemistry."; Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.; J. Proteome Res. 8:651-661(2009). Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-1018; ASN-1034; ASN-1184;ASN-1275; ASN-1301; ASN-1366 AND ASN-1485, AND MASS SPECTROMETRY.	19159218 [Abstract]
"Identification of N-linked glycoproteins in human milk by hydrophilicinteraction liquid chromatography and mass spectrometry."; Picariello G., Ferranti P., Mamone G., Roepstorff P., Addeo F.; Proteomics 8:3833-3847(2008). Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-184; ASN-1079; ASN-1093;ASN-1261; ASN-1301; ASN-1485 AND ASN-2162, AND MASS SPECTROMETRY.	18780401 [Abstract]
"Human plasma N-glycoproteome analysis by immunoaffinity subtraction,hydrazide chemistry, and mass spectrometry."; Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E.,Moore R.J., Smith R.D.; J. Proteome Res. 4:2070-2080(2005). Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-1809, AND MASSSPECTROMETRY.	16335952 [Abstract]